is nolva effective at eliminating estrogen?

[MASSIVEMONSTER]

always use nolva at 20mg a day and it seems to prevent gyno, therefore it muct block estrogen, right? also i dont hold water on it but i am reading arimidex is better? whats the crack?

 

[Mr.X]

always use nolva at 20mg a day and it seems to prevent gyno, therefore it muct block estrogen, right? also i dont hold water on it but i am reading arimidex is better? whats the crack?

bro, you've been around long enough. Nolvadex is a SERM, it competes for receptor, while Arimidex is an aromatase inhibitor (blocks the aromatase enzyme).

read info
Arimidex - Anastrozole info
NOLVADEX - tamoxifen citrate info

 

[Indy]

bro, you've been around long enough. Nolvadex is a SERM, it competes for receptor, while Arimidex is an aromatase inhibitor (blocks the aromatase enzyme).

read info
Arimidex - Anastrozole info
NOLVADEX - tamoxifen citrate info

Well said.

 

[MASSIVEMONSTER]

ok just read it. always been fine with just nolva so never questioned it.
some people say estrogen needs to be high on a cycle for best gains while others say estrogen is bad for prostate and other problems caused from it, so is it wise to use nolva or adex if you dont have gyno?

 

[Mr.X]

ok just read it. always been fine with just nolva so never questioned it.
some people say estrogen needs to be high on a cycle for best gains while others say estrogen is bad for prostate and other problems caused from it, so is it wise to use nolva or adex if you dont have gyno?

There is no major reason to use arimidex and nolvadex together. Just stick to arimidex...

high estrogen levels are not good for you, the side-effects are very bad for your health - from blood pressure problems, to gyno etc.

 

[MASSIVEMONSTER]

yeah but nolva will do my fine right at eliminating most estrogen? your just saying arimidex is better?

 

[Mr.X]

yeah but nolva will do my fine right at eliminating most estrogen? your just saying arimidex is better?

nolvadex does not 'eliminate' estrogen, it competes for receptors, did you read the links I posted?

 

[MASSIVEMONSTER]

yeah i know it competes for receptors but when i introduce nolva half way thru a cycle, i lose 4-5lb within a few days and get much harder and BP drops so it must be good at eliminating estrogen how ever it works otherwise this wouldnt happen???
arimidex is well expensive in uk. its about 100 quid to cover a 10 week cycle,
nolva only 25 quid.

 

[anal itch]

If this is what you want to hear then YES, it will completely eliminate estrogen in "your" system.

Come on bro, Mr.X answered you twice. You're killing me!

 

[MASSIVEMONSTER]

sorry didnt mean to go on

 

[wayneboard1]

man you are becoming a massive irritation and I haven't even been on here much over the past month or so. You REALLY need to use the search button more man, that will answer a lot of your questions.

 

[JuicedAthletics]

Not even just the search function.. I have read you ask the same question before.. I am not a paying member and im not a mod either, so i mean no disrespect towards you...
But for your own good, I would limit your questions so that the mods and vets do not start to ignore your requests.. Just my 2 cents.. Not stepping on anyones toes...

 

[wayneboard1]

Not even just the search function.. I have read you ask the same question before.. I am not a paying member and im not a mod either, so i mean no disrespect towards you...
But for your own good, I would limit your questions so that the mods and vets do not start to ignore your requests.. Just my 2 cents.. Not stepping on anyones toes...

thats a good point man.

 

[bluehen]

man you are becoming a massive irritation and I haven't even been on here much over the past month or so. You REALLY need to use the search button more man, that will answer a lot of your questions.

We need to just post up your avi everytime he posts.

 

[Anthony Roberts]

No...nolvadex will not reduce overall estrogen...Here's how Nolvadex works:

Ok...this is a bit complicated, but here it is (don't say I didn't warn you):
Nolvadex is a Selective Estrogen Receptor Modulator. This means that it acts on the Estrogen receptor (called the "ER" but having nothing to do with George Clooney or Anthony Edwards). Now, this also means that it acts as an estrogen in some tissues which acts as an antiestrogen in some tissues.

The estrogen receptor's ligand binding domain is just of a number of amino acid sequences "folded" into a series of helixes, which have the ability to change conformation. Different stimuli (such as Nolvadex) are well documented to have the ability to change the conformation of a very important helix (helix 12, for those keeping score at home).

When estradiol binds the ER, this particular helix takes on a conformation that allows DNA transcription to mRNA, and estrogenic effects are then expressed in the body. When Nolvadex (Tamoxifen) binds to it, the antagonist changes the shape of this helix in such a way that it now folds (or bends) in such a way to prevent proper binding of estrogen, and subsequent transcription of DNA to mRNA.

The ER (remember, no George Clooney) contains two areas called AF-1 and AF-2. Nolvadex actually only inactivates AF-2. Since there are two areas that can can initiate transcription of mRNA, and Nolvadex is estrogenic in some tissues but an anti-estrogen (sort of) in others,it is possible that AF-1 is the dominant domain of estrogen gene transcription in the liver (for example) but not in mammary (breast) tissue.

Ok...so...yeah...I think that may not have been what you were looking for...

If you have further questions on this, just tell me, or if you need some kind of better (easier?) explanation...