is DHEA suppressive to the hpta

[lartinos]

I wouldn't think so, but finding info this stuff is hard.

 

[KOArtist]

i know the 7 keto type isnt. Not sure about the others

 

[doublebicep]

My take on it being HPTA surpressive is no, it is not. Here is a good summary of what it does:

DHEA is as a precursor hormone, meaning that it is a source material which the body converts into other hormones. It is used in making hormones such as estrogen and testosterone.

So, the lack of DHEA may cause a decline in testosterone because of the lack of precursor (DHEA) that is need for your body to manufacture test.

That's my take on it.

 

[lartinos]

Alright thats I was thinking, but wasn't really sure.

 

[b1ewsw32]

My take on it being HPTA surpressive is no, it is not. Here is a good summary of what it does:

DHEA is as a precursor hormone, meaning that it is a source material which the body converts into other hormones. It is used in making hormones such as estrogen and testosterone.

So, the lack of DHEA may cause a decline in testosterone because of the lack of precursor (DHEA) that is need for your body to manufacture test.

That's my take on it.

IMHO I dont think the small amount of testosterone produced in the adrenals via DHEA is near enough to be suppressive, unless a diseased condition of adrenal hyperplasia, where the high adrenal test could be enough to cause negative feedback with co-responding hpta suppresion.

I couldn't find any clear studies involving DHEA and HPTA suppresion...so take this one with a grain of salt.....

The effect of sex steroids on the degradation of LRH by hypothalamic homogenates.

Tate AC, Swift AD.

Extract of hypothalami was prepared which contained peptidase capable of degrading LRH. The degradation of LRH by this extract either alone or under the influence of oestrogens, androgens and cholesterol, when added to the extract was measured. Oestrone, oestradiol and oestriol (1 pg to 100 pg) stimulated mean peptidase activity significantly (P less than 0.001) in a dose-dependent manner. Testosterone (0.1 ng to 10 ng) also caused a dose-dependent increase in degradation of LRH, the two highest doses used significantly increasing the mean activity (P less than 0.001). Only the highest dose of androstenedione (10 ng) or dehydroepiandrosterone (10 ng) caused a significant increase of the mean LRH degradation (P less than 0.05). Neither cholesterol nor dihydrotestosterone increased peptidase activity when added to the extract. It is suggested that it is possible that these peptidase enzymes could occupy a role in the negative feedback of steroids on the hypothalamus.

So we see it would take high doses of DHEA to cause degration of LRH.

B32

 

[liftsiron]

Dhea is not going to affect htpa in any significant way. It may be slightly beneficial to the htpa in the real old guys. You can go to the life extension website for more info.