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Interleukin-15 (or other Interleukins)
- Thread starter LT3
- Start date
LT3 said:
It's protein, a chain of amino acids, 123 if I remember correctly, shit is EXPENSIVE though.
Interleukin (IL)-15 is a pleiotropic pro-inflammatory cytokine that is expressed in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. IL-15 promotes activation of T cells, neutrophils and macrophages, and is critical to dendritic cell function in several model systems. Recent emerging data suggest that IL-15 may serve as a useful therapeutic target across a range of disease states. Advances in the past year highlight the beneficial effect of IL-15 neutralisation in models of psoriasis and diabetes. Further evidence for IL-15 expression and effector function has emerged across a range of rheumatic disorders, including juvenile inflammatory arthritis, rheumatoid arthritis and Kawasaki disease. Interleukin-15 (IL-15) is a gamma-common cytokine, which plays an important role in the development, survival and proliferation of NK, NK T and CD8+ T cells.
LT3
New member
WOW! thats insane, i didnt anticipate it to be like that. the thing that im wondering is, why isnt this more popular in sports. price is one thing, but how come we dont discuss it further. i for one dont know anything about and im fascinated from what people say. so i wanna know more, but every thing that i find is related to diseases as opposed to muscle building and bbing and what not.
NYBodyguard
New member
CME talks about it he doesnt really rave about it or anything like its some wonder drug
LT3 said:
Very true, and that's an issue right there. Once a valid medical use is found, it will be scheduled in the near future. IGF-1 is slated to be scheduled as they now use it in hospitals with positive results. You can buy it online all over the place from research companies that are creating it, once it goes scheduled you wont be able to do that any longer.
LT3
New member
ok this is what i found about bbing and interleukin 15
http://www.bodybuilding.com/fun/core_march_3.htm
from what i gather its similar to a precursor for growth factors.
http://www.bodybuilding.com/fun/core_march_3.htm
from what i gather its similar to a precursor for growth factors.
NYBodyguard
New member
ronnie has been training for 20 years, now in no way is he natrual but i also know time plays a big role in the serious pro style size
these guys are strict with diet and training for years and years yeah drugs are a big deal too but its way more then that
these guys are strict with diet and training for years and years yeah drugs are a big deal too but its way more then that
LT3
New member
agree, but i would be surprised if some of these guys play around with interleukin 15
for the mean time this is what i found
Division of Gerontology and Geriatric Medicine, University of Washington, Seattle 98195, USA. [email protected]
Interleukin-15 (IL-15) is a novel anabolic factor for skeletal muscle which inhibits muscle wasting associated with cancer (cachexia) in a rat model. To develop a cell culture system in which the mechanism of the anabolic action of IL-15 on skeletal muscle could be examined, the mouse C2 skeletal myogenic cell line was transduced with a retroviral expression vector for IL-15 and compared to sister cells transduced with a control vector. Overexpression of IL-15 induced fivefold higher levels of sarcomeric myosin heavy chain and alpha-actin accumulation in differentiated myotubes. Secreted factors from IL-15-overexpressing myogenic cells, but not from control cells, induced increased myofibrillar protein accumulation in cocultured control myotubes. IL-15 overexpression induced a hypertrophic myotube morphology similar to that described for cultured myotubes which overexpressed the well-characterized anabolic factor insulin-like growth factor-I (IGF-I). However, in contrast to IGF-I, the hypertrophic action of IL-15 on skeletal myogenic cells did not involve stimulation of skeletal myoblast proliferation or differentiation. IL-15 induced myotube hypertrophy at both low and high IGF-I concentrations. Furthermore, in contrast to IGF-I, which stimulated only protein synthesis under these culture conditions, IL-15 both stimulated protein synthesis and inhibited protein degradation in cultured skeletal myotubes. These findings indicate that IL-15 action on skeletal myogenic cells is distinct from that of IGF-I. Due to the ability of IGF-I to stimulate cell division and its association with several forms of cancer, controversy exists concerning the advisability of treating cachexia or age-associated muscle wasting with IGF-I. Administration of IL-15 or modulation of the IL-15 signaling pathway may represent an alternative strategy for maintaining skeletal muscle mass under these conditions.
for the mean time this is what i found
Division of Gerontology and Geriatric Medicine, University of Washington, Seattle 98195, USA. [email protected]
Interleukin-15 (IL-15) is a novel anabolic factor for skeletal muscle which inhibits muscle wasting associated with cancer (cachexia) in a rat model. To develop a cell culture system in which the mechanism of the anabolic action of IL-15 on skeletal muscle could be examined, the mouse C2 skeletal myogenic cell line was transduced with a retroviral expression vector for IL-15 and compared to sister cells transduced with a control vector. Overexpression of IL-15 induced fivefold higher levels of sarcomeric myosin heavy chain and alpha-actin accumulation in differentiated myotubes. Secreted factors from IL-15-overexpressing myogenic cells, but not from control cells, induced increased myofibrillar protein accumulation in cocultured control myotubes. IL-15 overexpression induced a hypertrophic myotube morphology similar to that described for cultured myotubes which overexpressed the well-characterized anabolic factor insulin-like growth factor-I (IGF-I). However, in contrast to IGF-I, the hypertrophic action of IL-15 on skeletal myogenic cells did not involve stimulation of skeletal myoblast proliferation or differentiation. IL-15 induced myotube hypertrophy at both low and high IGF-I concentrations. Furthermore, in contrast to IGF-I, which stimulated only protein synthesis under these culture conditions, IL-15 both stimulated protein synthesis and inhibited protein degradation in cultured skeletal myotubes. These findings indicate that IL-15 action on skeletal myogenic cells is distinct from that of IGF-I. Due to the ability of IGF-I to stimulate cell division and its association with several forms of cancer, controversy exists concerning the advisability of treating cachexia or age-associated muscle wasting with IGF-I. Administration of IL-15 or modulation of the IL-15 signaling pathway may represent an alternative strategy for maintaining skeletal muscle mass under these conditions.
southpaw45
New member
ot
wtf is Kawasaki Disease, riding your ninja too much?!?
wtf is Kawasaki Disease, riding your ninja too much?!?
big_boy_1
New member
They are involved in the natural inflammation -you always produce some when training-, and its subsequent overhealing, -with muscle gain- process.LT3 said:
They are legal, or at least not illegal for "research and development", not new been for many years, only a few years ago bodybuilders were aware of them.LT3 said:
For cost consider $1000 a day.
Its primarily produced INSIDE muscles, so when taken systemically, they produce lot of side effects with relatively little gains. Best to look for something that increases IL-15 release.LT3 said:
The_Chemist
New member
A study published in the Journal of Endocrinology in 1995 showed IL-15 doubled the rate of hypertrophy in skeletal muscle tissue. Interesting? Well the same study showed that stacking IL-15 with IGF-1 (insulin like growth factor-1; the stuff GH is converted into by the liver and other sites) increased muscular hypertrophy (excessive development/growth) by 500%. How is that for mediation?
I mentioned this in the other thread about ronnie coleman. If you really wanna know what the cutting edge drugs are, read
Scienific American
Volume 10, isuue # 2, 1999
Interlukin, Mechano GF, IGF- 1, and HGH with insulin will produce results that will eclipse ones genetics. Add this sort of stack to a champions genes, and you get a Dorian yates, or Ronnie Coleman.
I mentioned this in the other thread about ronnie coleman. If you really wanna know what the cutting edge drugs are, read
Scienific American
Volume 10, isuue # 2, 1999
Interlukin, Mechano GF, IGF- 1, and HGH with insulin will produce results that will eclipse ones genetics. Add this sort of stack to a champions genes, and you get a Dorian yates, or Ronnie Coleman.
The_Chemist
New member
A little bit is also metioned in CME, if anyone owns it.
deezknuckles
New member
Recombinant humanized proteins are very expensive because the process is very technically demanding. You basically you transfect a bacterial cell (i.e E.Coli), a yeast cell (i.e. brewers yeast) or a mammiliam cell (i.e. chinese hamster ovary) to mass produce a particular protein by inserting DNA into the cell. The interleukins have been in development for ~20 years and only IL-2 is FDA approved (for metastatic melanoma). It is quite toxic and only produces responses in ~5-10% of pts. The other interleukins have not panned out and are still experimental at this point. IL-15 wouldn't be the first cytokine that had impressive results in mice models that turned out to be total bust in humans.
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