Please Scroll Down to See Forums Below has anyone encountered trouble urinating and or bph while on igf 1 r3 . Since starting I have weak flow and start an stop . It usually gets better weeks after I stop.( I have used off an on for over a year) An if so what have you done to lessen or stop this. I like igf but this has become a major issue.
igf 1 r3 an enlarged prostate
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Prostate cancer risk and IRS1, IRS2, IGFI, and INS polymorphisms : Strong association of IRSI G972R variant and cancer risk
Auteur(s) / Author(s)
NEUHAUSEN Susan L. (1) ; SLATTERY Martha L. (2) ; GARNER Chad P. (1) ; DING Yuan C. (1) ; HOFFMAN Michael (2) ; BROTHMAN Arthur R. (3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Medicine, Division of Epidemiology, University of California Irvine, Irvine, California, ETATS-UNIS
(2) Health Research Center, University of Utah, Salt Lake City, Utah, ETATS-UNIS
(3) Departments of Pediatrics and Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, ETATS-UNIS
Résumé / Abstract
BACKGROUND. As cellular proliferation is central to the carcinogenic process, pathways that regulate proliferation may be important. Therefore, genes in the insulin and the insulin-like growth factor signaling pathways are plausible candidates for susceptibility genes for prostate cancer. We hypothesized that functional polymorphisms in INS, IRS1, IRS2, and IGF1 may be associated with prostate cancer. METHODS. We studied 199 incident prostate cancer cases and 267 age-matched controls. Genotyping was performed for the INS + 1127 Ins-PstI, IRS1 G972R, IRS2 G1079D, and the IGF1 CA-repeat polymorphisms. Outcomes were prostate cancer, Gleason score, and AJCC stage. RESULTS. The IRS1 G972R GR/RR genotypes were associated with a significant 2.8-fold increased risk for prostate cancer (95% CI 1.5-5.1, P = 0.0007). The other variants were not significantly associated with prostate cancer. The IRS1 G972R GR/RR genotypes were also significantly associated with more advanced Gleason score (P = 0.001) and AJCC stage (P = 0.004). CONCLUSIONS. These results support a role of the insulin and/or insulin-like growth factor pathways in the etiology of prostate cancer.
Prostate cancer risk and IRS1, IRS2, IGFI, and INS polymorphisms : Strong association of IRSI G972R variant and cancer risk
Auteur(s) / Author(s)
NEUHAUSEN Susan L. (1) ; SLATTERY Martha L. (2) ; GARNER Chad P. (1) ; DING Yuan C. (1) ; HOFFMAN Michael (2) ; BROTHMAN Arthur R. (3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Medicine, Division of Epidemiology, University of California Irvine, Irvine, California, ETATS-UNIS
(2) Health Research Center, University of Utah, Salt Lake City, Utah, ETATS-UNIS
(3) Departments of Pediatrics and Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, ETATS-UNIS
Résumé / Abstract
BACKGROUND. As cellular proliferation is central to the carcinogenic process, pathways that regulate proliferation may be important. Therefore, genes in the insulin and the insulin-like growth factor signaling pathways are plausible candidates for susceptibility genes for prostate cancer. We hypothesized that functional polymorphisms in INS, IRS1, IRS2, and IGF1 may be associated with prostate cancer. METHODS. We studied 199 incident prostate cancer cases and 267 age-matched controls. Genotyping was performed for the INS + 1127 Ins-PstI, IRS1 G972R, IRS2 G1079D, and the IGF1 CA-repeat polymorphisms. Outcomes were prostate cancer, Gleason score, and AJCC stage. RESULTS. The IRS1 G972R GR/RR genotypes were associated with a significant 2.8-fold increased risk for prostate cancer (95% CI 1.5-5.1, P = 0.0007). The other variants were not significantly associated with prostate cancer. The IRS1 G972R GR/RR genotypes were also significantly associated with more advanced Gleason score (P = 0.001) and AJCC stage (P = 0.004). CONCLUSIONS. These results support a role of the insulin and/or insulin-like growth factor pathways in the etiology of prostate cancer.
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