HRT and cycle

[liftr486]

OK.....ive decided to do:

40mg Dbol and 500mg Test for six weeks then go back to HRT 100mg/week.

what does of letro would u use?

i really need to put size on


wat u guys think?

 

[liftr486]

any opinions?


2.5mg letro should keep me bone dry right? feeling a little something but that could just be my mind fucking with me.

 

[goin on 4T]

any opinions?


2.5mg Femera - letrozole - should keep me bone dry right? feeling a little something but that could just be my mind fucking with me.

Dont know if this will help or do a search in the other forums...

Drug Name: Femara (letrozole) Tablets
The following information is obtained from various newswires, published medical journal articles, and medical conference presentations.

Company: Novartis
Approval Status: Approved January 2001
Treatment for: Hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer


General Information
Femara has been approved for the first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer. The drug is a once-a-day oral treatment originally approved in 1997 for advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

Estrogen has been shown to stimulate the growth of certain hormone-dependent cancer cells. In postmenopausal women, estrogen is primarily produced from the conversion of adrenal androgens to estrogen. This conversion is catalyzed by an enzyme known as aromatase. Femara contains 2.5 mg of letrozole, a compound that blocks the action of aromatase and therefore inhibits the conversion of androgens to estrogens.

Advanced breast cancer is the second leading cause of cancer death among women in the United States. Over 120,000 American women have advanced breast cancer, and approximately half of the 182,000 newly diagnosed cases of breast cancer each year are in an advanced stage when detected.

Clinical Results
Among other studies, Femara was evaluated in a randomized, double-blind, multinational phase III trial that compared Femara 2.5 mg to tamoxifen 20 mg in 907 postmenopausal women with locally advanced (stage IIIB) disease, metastatic breast cancer, or recurrences not amenable to treatment with surgery or radiotherapy. Results of the trial demonstrated that Femara delayed progression of advanced breast cancer for 9.4 months compared to 6.0 months for tamoxifen. Significant differences were also observed between Femara and tamoxifen in terms of objective response rate (30% vs. 20%), clinical benefit (49% vs. 38%) and time to treatment failure (9.1 months vs. 5.7 months). Femara and tamoxifen were equally well tolerated.

Side Effects
Reported adverse events for Femara vs. tamoxifen included (but are not limited to) the following:

Bone pain (20% vs. 18%)
Hot flushes (18% vs. 15%)
Back pain (17% vs. 17%)
Nausea (15% vs. 16%)
Dyspnea (abnormal breathing) (14% vs. 15%)
Arthralgia (severe joint pain) (14% vs. 13%)
Fatigue (11% vs. 11%)
Coughing (11% vs. 10%)


Mechanism of Action
Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult non-tumor and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH. Letrozole selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis.

Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. Treatment of women with letrozole significantly lowers serum estrone, estradiol and estrone sulfate and has not been shown to significantly affect adrenal corticosteroid synthesis, aldosterone synthesis, or synthesis of thyroid hormones. (from Novartis Revised Package Insert)

 

[smoke67]

Why femara, I would just use aromasin and nolva if the nips get to acting up.
This is what I always do. No PCT just back to the HRT dose of 150 EW

 

[thelion2005]

I like this simple and effective cycle. Add 0.5 a-dex on Thurs and Sun. Have fun.

Watch the sides like increased bp and total cholesterol and PSA. All these will jump, but return to normal when you come back to low dosage HRT.

 

[liftr486]

no adex on hand, only femara.

would aifm do the trick?

 

[njmuscleguy]

I like this simple and effective cycle. Add 0.5 a-dex on Thurs and Sun. Have fun.

Watch the sides like increased bp and total cholesterol and PSA. All these will jump, but return to normal when you come back to low dosage HRT.

A I's will raise you liver enzymes as well, so if you're getting your routine bloodwork after you're done with your "cycle", give yourself at least a month before getting tested, otherwise your doctor may get alarmed (or suspicious)

Skip the AIFM and just use the le-tro if that's all you have, it's more tried and true

 

[Dopamineloveaffair]

Be careful the Letrozole doesn't lower your estrogen too much. If your sex drive, mood, and energy go south, as well as having sore joints I'd ease up on your dosage.

Letrozole is a very tricky drug to dose right unless you are trying to get extremely low estrogen levels prior to a BB contest. It's very easy to overshoot.

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http://www.mens-hormonal-health.com/