I'm running 500 Test and 300 Deca which takes 3 ccs for a full dose. Week 1 I shot it all at once ...the full 3 ccs, and I was slayed. My ass felt like it was hit with the blunt end of an axe blade. Since, I've split my week up into two 1.5cc shots and I'm totally fine now....shot ass on Sunday and never even felt it.