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How does one notice insulin resistance?

Metabolic syndrome is defined by the National Cholesterol Education Program as the presence of any three of the following conditions:

-excess weight around the waist (waist measurement of more than 40 inches for men and more than 35 inches for women)


-high levels of triglycerides (150 mg/dL or higher)


-low levels of HDL, or "good," cholesterol (below 40 mg/dL for men and below 50 mg/dL for women)


-high blood pressure (130/85 mm Hg or higher)


-high fasting blood glucose levels (110 mg/dL or higher)



Insulin resistance and pre-diabetes usually have no symptoms. You may have one or both conditions for several years without noticing anything. If you have a severe form of insulin resistance, you may get dark patches of skin, usually on the back of your neck. Sometimes people get a dark ring around their neck. Other possible sites for these dark patches include elbows, knees, knuckles, and armpits. This condition is called acanthosis nigricans.

If you have a mild or moderate form of insulin resistance, blood tests may show normal or high blood glucose and high levels of insulin at the same time.


Anyone 45 years or older should consider getting tested for diabetes. If you are overweight and age 45 or older, it is strongly recommended that you get tested. You should consider getting tested if you are younger than 45, overweight, and have one or more of the following risk factors:

family history of diabetes


low HDL cholesterol and high triglycerides


high blood pressure


history of gestational diabetes (diabetes during pregnancy) or gave birth to a baby weighing more than 9 pounds


minority group background (African American, American Indian, Hispanic American/Latino, or Asian American/Pacific Islander)
Diabetes and pre-diabetes can be detected with one of the following tests:

A fasting glucose test measures your blood glucose after you have gone overnight without eating. This test is most reliable when done in the morning. Fasting glucose levels of 100 to 125 mg/dL are above normal but not high enough to be called diabetes. This condition is called pre-diabetes or impaired fasting glucose, and it suggests that you have probably had insulin resistance for some time. IFG is considered a pre-diabetic state, meaning that you are more likely to develop diabetes but do not have it yet.

A glucose tolerance test measures your blood glucose after an overnight fast and 2 hours after you drink a sweet liquid provided by the doctor or laboratory. If your blood glucose falls between 140 and 199 mg/dL 2 hours after drinking the liquid, your glucose tolerance is above normal but not high enough for diabetes. This condition, also a form of pre-diabetes, is called impaired glucose tolerance and, like IFG, it points toward a history of insulin resistance and a risk for developing diabetes.

These tests give only indirect evidence of insulin resistance. The test that most accurately measures insulin resistance is too complicated and expensive to use as a screening tool in most doctors' offices. The test, called the euglycemic clamp, is a research tool that helps scientists learn more about sugar metabolism problems. Insulin resistance can also be assessed with measurement of fasting insulin. If conventional tests show that you have IFG or IGT, your doctor may suggest changes in diet and exercise to reduce your risk of developing diabetes.

If your blood glucose is higher than normal but lower than the diabetes range, have your blood glucose checked in 1 to 2 years



http://diabetes.niddk.nih.gov/dm/pubs/insulinresistance/
 
Get a blood glucose monitor. Monitor your values 1 and 2 hours after meals, and after 10 hours of fasting - normal fasting values are 60-110mg/dl, 90 and above usually indicates some type of insulin resistance.
 
If you are talking about insulin resistence from synthetic GH use, the symptoms are much easier to spot. Within a couple hours after the injection, you will feel mildly dizzy, shakey, disoriented. Not like the spike from insulin, but still noticeable.
 
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