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Helping the liver
- Thread starter mphowells
- Start date
macrophage69alpha
New member
glucorell (R+ lipoic)- strongly hepatoprotectant
Sesamax (sesamin/episesamin)- greatly enhances liver metabolism and is a strong anti-oxident in the liver
WATER- nothing puts strain on kidney and liver like dehydration.
Sesamax (sesamin/episesamin)- greatly enhances liver metabolism and is a strong anti-oxident in the liver
WATER- nothing puts strain on kidney and liver like dehydration.
Fukkenshredded
New member
Androgenic/Anabolic Steroid-Induced Toxic Hepatitis.
Journal of Clinical Gastroenterology. 35(4):350-352, October 2002.
Stimac, Davor M.D., Ph.D.; Milic, Sandra M.D.; Dintinjana, Renata Dobrila M.D., Ph.D.; Kovac, Drazen M.D., Ph.D.; Ristic, Smiljana Ph.D.
Abstract:
Athletes and bodybuilders often misuse androgenic/anabolic steroids. When used in therapeutic doses, these drugs produce clinical jaundice in just a small number of recipients. We present a 26-year-old male bodybuilder who self-administered high doses of androgenic/anabolic steroids that induced liver damage. One month before admission to the hospital, he used testosterone enanthate (500 mg intramuscularly, twice weekly), stanozolol (40 mg/d), and methylandrostenediol (30 mg/d by mouth, for 5 weeks). On admission, his bilirubin level was 470 [mu]mol/L (direct, 360 [mu]mol/L), his aspartate aminotransferase (AST) level was 5,870 IU/L, his alanine aminotransferase (ALT) level was 10,580 IU/L, his alkaline phosphatase (ALP) level was 152 IU/L, his gamma-glutamyl-transpeptidase level was 140 IU/L, his albumin level was 27.6 g/L, and his prothrombin time was 29%. During the patient's prolonged hospitalization, multiple tests and liver biopsy were performed, showing only toxic hepatic lesions. The patient was provided with supportive medical treatment. Clinical signs and laboratory findings improved substantially 12 weeks after the patient discontinued androgenic/anabolic steroids. The reasons for presenting this case were the much higher values of AST and ALT levels than reported in other studies, although the values of bilirubin and ALP were similar to those found in the literature. To our knowledge, it is the first case of toxic hepatitis induced by androgenic/anabolic steroids with predominantly hepatocellular necrosis instead of intrahepatic cholestasis.
Journal of Clinical Gastroenterology. 35(4):350-352, October 2002.
Stimac, Davor M.D., Ph.D.; Milic, Sandra M.D.; Dintinjana, Renata Dobrila M.D., Ph.D.; Kovac, Drazen M.D., Ph.D.; Ristic, Smiljana Ph.D.
Abstract:
Athletes and bodybuilders often misuse androgenic/anabolic steroids. When used in therapeutic doses, these drugs produce clinical jaundice in just a small number of recipients. We present a 26-year-old male bodybuilder who self-administered high doses of androgenic/anabolic steroids that induced liver damage. One month before admission to the hospital, he used testosterone enanthate (500 mg intramuscularly, twice weekly), stanozolol (40 mg/d), and methylandrostenediol (30 mg/d by mouth, for 5 weeks). On admission, his bilirubin level was 470 [mu]mol/L (direct, 360 [mu]mol/L), his aspartate aminotransferase (AST) level was 5,870 IU/L, his alanine aminotransferase (ALT) level was 10,580 IU/L, his alkaline phosphatase (ALP) level was 152 IU/L, his gamma-glutamyl-transpeptidase level was 140 IU/L, his albumin level was 27.6 g/L, and his prothrombin time was 29%. During the patient's prolonged hospitalization, multiple tests and liver biopsy were performed, showing only toxic hepatic lesions. The patient was provided with supportive medical treatment. Clinical signs and laboratory findings improved substantially 12 weeks after the patient discontinued androgenic/anabolic steroids. The reasons for presenting this case were the much higher values of AST and ALT levels than reported in other studies, although the values of bilirubin and ALP were similar to those found in the literature. To our knowledge, it is the first case of toxic hepatitis induced by androgenic/anabolic steroids with predominantly hepatocellular necrosis instead of intrahepatic cholestasis.
MeatheadJD
New member
Ulter said:
what is short periods?
is 16 weeks possible to shut down liver?
macrophage69alpha
New member
Fukkenshredded said:
this does not mean that these oral steroids were not liver toxic, merely that this is the only clinically described case where the user suffered from liver cell death instead of fatty liver (the "fancy" name for which is intrahepatic cholestasis).
J Okla State Med Assoc. 1994 Sep;87(9):399-404. Related Articles, Links
Androgenic/anabolic steroid-induced intrahepatic cholestasis: a review with four additional case reports.
Gurakar A, Caraceni P, Fagiuoli S, Van Thiel DH.
Oklahoma Transplantation Institute, Baptist Medical Center of Oklahoma, Oklahoma City 73112.
Four cases of severe cholestasis attributed to anabolic/androgenic steroid usage are reported. These cases are reported because each was severely jaundiced (peak bilirubin level 62 mg/dl), developed advanced hepatic failure (Child's Class B) and was referred to a liver transplant center for consideration for liver transplantation. The hepatic dysfunction and cholestasis in each persisted for 3 months or more. Moreover, in two the hepatic dysfunction was complicated by the development of renal dysfunction and anemia requiring additional medical interventions. With prolonged medical therapy, each case recovered fully without transplantation. These cases are important because they demonstrate that drug-induced cholestasis can be prolonged, can mimic advanced liver disease, and can be associated with co-existent renal dysfunction.
Schweiz Rundsch Med Prax. 2002 Sep 18;91(38):1561-4. Related Articles, Links
[Cholestatic jaundice and pruritus]
[Article in German]
Stocker C, Hardmeier B, Looser M, Scharf C, Greminger P.
Medizinische Poliklinik, Departement fur Innere Medizin, Universitatsspital Zurich.
The 38 year old male patient was admitted to our clinic with jaundice and invalidating pruritus of unknown origin. The primary evaluation made by the practitioner of the patient and the initial examinations performed in the clinic revealed no diagnosis. In particular, an infectious liver disease could be excluded. Reevaluation of anamnestic data revealed then the in-take of Dianabol, an often used anabolic steroid as the most possible reason for the cholestatic hepatopathy.
