Okay, here it is again...from now on you guys need to search for this kind of stuff--I've posted this a minimum of four times here, so this is the last.
A little insight about relative toxicity...
(I reworded this slightly for clarification))
All oral steroids have the 17 alpha alkylation, a chemical bond that must be broken before the drug becomes bioavailable.
Now, some steroids, like winstrol, have an additional bond that adds to its toxicity. Most orals have either one or two chemical bonds that need to be broken down in order to render the steroid bioavailable.
The reason why Halotestin is the harshest on the liver is because halo incorporates a combination of three chemical bonds that are all toxic features. These include a 17-a methyl group, a 9-a fluorine, and a 11-OH group.
Halotestin alone has all three of these bonds.
The chemical name for fluoxymesterone is androst-4-en-3-one, 9-fluoro11,17-dihydroxy-1,7-methyl-,(11b,7b)-. So we see that it has 17A methyl(17alpha alkylated), which is indeed toxic. This is the bond that gives us the name 17aa, and the one that is common among all orals.
The second arrangement that Halotestin contains is 9-alpha fluorine (fuorine is used to protect substances from breaking down, as with sodium fluoride, etc). This version of Fluorine is also very toxic.
Lastly, halotestin contains some of the 11-Hydroxyl Group which is must be enzymatically reduced to the corresponding 11-hydroxy derivative before becoming biologically active. This reaction is carried out by a distinct 11-hydroxysteroid dehydrogenase isozyme in the liver that operates in a reductive capacity.
This process alone is very toxic, not just to the liver, but to the kidneys.
These are, specifically, the three bonds that Fonz has repeatedly referred to in his posts about tis drug's toxicity. He unfortunately one time used the phrase 'triple bond', which led to some dispute because it is not actually a triple bond, but three seperate chemical bonds (which is what he already knew, but others misunderstood).
The idea that all orals are equally toxic is a dangerous one. They are not. Do your research to understand the differences.
With halotestin, andronergic activity is increased 10 times and anabolic activity increased 20 times over that of 17-a methyl testosterone. This gives you an idea of its efficacy, and why it is such a favorite for those looking for added strength.
Last edited by Fukkenshredded on 18-Mar-2003 at 04:00 AM