Hey guys, I've been running GW at 10mg/day for the past 2 weeks. My endurance is definitely up, I am able to keep going and going, and then take a short break, and never feel exhausted. It's awesome!
However, my main concerns lie with the PPAR delta agonism. I have read dozens of studies on the promotion of colorectal cancer growth due to the agonism. HOWEVER! the studies done with mice were genetically mutated to lack the APC gene, which in turn gives them FAP (a disorder where hundreds of colon polyps are caused to grow and has almost a 100% cancer risk).
To my understanding... the 501516 doubled the amount of already abnormal polyps due to the FAP disorder which affects about 1 in 7-22k people. Therefore, is it safe to say, that in human individuals WITHOUT the FAP disorder, should not have any issues with the minute dosages compared to the mice studies?
Also, the mice studies were run for 2 years as opposed to 2-8 week intervals. I am basically just trying to alleviated my own concerns and others'. Of course, if a person has a known hereditary disposition to FAP (it is dominant), then I would NOT even come near this drug! Because it was proven to potentiate the development of polyps.
All-in-all, GW is fantastic aside from the potential side affects; however, the side affects were so strongly displayed in the mice due to the abnormality in the genome. Somebody please correct me if any of my logic is incorrect, I just want to do the healthiest thing possible. And for those reasons, I will try to find out if my father has polyp issues and limit my runs to 2-3 weeks at a time.
best regards and appreciation
NOT TRYIGN TO BEAT A DEAD HORSE! I just havent seen these connections made previously.