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liquidanny
New member
What I am interested in getting is more information of OTC supplements that allow for a positive Somatotropin/Somatostating
Ratio. Call it "getting the most bang out of your GH"
It is reasonably clear that GH releasers are not anabolic in the same way as Testosterone or the anabolic Steroids. At the same time, they are clearly ergogenic-- using the term loosely. It is also fairly apparent that the use of Human Growth Hormone (HgH), even the synthetic stuff, is anabolic, though not as much so as many Steroids. These observations started me searching the literature for an explanation. How is this possible? What is the mechanism through which GH releasers work? Is the pathway for HgH different from GH releasers?
The answer seems to be "yes". The reason may rest in the sequence in which the group of growth hormones are released and the balance between them. Synthetic HgH appears to the body to be Somatotropin. Somatotropin it appears is the anabolic member of the GH family. It is, however, only anabolic to the extent that it exceeds the levels of Somatostatin. The role of Somatomedin and Somatocrinin is less clear. Let us look a bit more closely at the interaction between these and the other related hormones.
It appears from the research that Somatotropin and Somatostatin, in effect, "neutralize" each other in a process common in the body. They seek to maintain stasis. The net result being no increase in muscle size. When one injects HgH, Somatotropin levels rise rapidly but since the normal pathway has not been triggered there is no corresponding level in Somatostatin. Under these conditions, until the body can produce a balancing level of Somatostatin the anabolic drive is triggered and muscle growth is stimulated. Unfortunately, so is bone and possibly organ growth in the viscera. This can lead to Acromegaly and Liver and/or Kidney damage with potentially fatal consequences.
These health risks are much reduced by age, Older individuals, having lower natural GH secretion levels, are likely to derive far more benefit from the use of exogenous HgH. This explains why a number of medical spas in Mexico and Europe are helping to reverse the the apparent signs of aging through the use of HgH.
Much more needs to be learned about the use of HgH for all types of individuals from young to old but it seems clear at this point that HgH does have an anabolic as well as ergogenic effect, albeit a risky one for most bodybuilders.
Our exploration now turns to the use of GH releasers. There are many substances that have been found to raise serum GH levels. What is rarely looked at in studies of the substrates or combinations of substrates is which hormone's levels are being raised and what ratios these elevated levels have to the other members of the group. It would appear that most GH releasing metabolites raise Somatotropin levels but with a corresponding increase in Somatostatin levels. This seems to produce a net wash in terms of anabolic drive but not in lipolytic drive. It is the observation of this phenomenon that leads me to strongly suspect that it is the action of another of the GH family that triggers the lipolytic effect. Strong suspicion falls to Somatomedin or Somatocrinin or more likely the balance between them.
Look at it this way, the ratio between Somatotropin and Somatostatin regulates the anabolic effect while the ratio between Somatomedin and Somatocrinin regulate the lipolytic effect. If this is true, and research will be required to prove it, then GH releasing combinations might be optimized for the desired effect. In the months to come, I'll be describing combinations of Over-the-Counter (OTC) supplements that will stimulate different GH ratios.
Ratio. Call it "getting the most bang out of your GH"
It is reasonably clear that GH releasers are not anabolic in the same way as Testosterone or the anabolic Steroids. At the same time, they are clearly ergogenic-- using the term loosely. It is also fairly apparent that the use of Human Growth Hormone (HgH), even the synthetic stuff, is anabolic, though not as much so as many Steroids. These observations started me searching the literature for an explanation. How is this possible? What is the mechanism through which GH releasers work? Is the pathway for HgH different from GH releasers?
The answer seems to be "yes". The reason may rest in the sequence in which the group of growth hormones are released and the balance between them. Synthetic HgH appears to the body to be Somatotropin. Somatotropin it appears is the anabolic member of the GH family. It is, however, only anabolic to the extent that it exceeds the levels of Somatostatin. The role of Somatomedin and Somatocrinin is less clear. Let us look a bit more closely at the interaction between these and the other related hormones.
It appears from the research that Somatotropin and Somatostatin, in effect, "neutralize" each other in a process common in the body. They seek to maintain stasis. The net result being no increase in muscle size. When one injects HgH, Somatotropin levels rise rapidly but since the normal pathway has not been triggered there is no corresponding level in Somatostatin. Under these conditions, until the body can produce a balancing level of Somatostatin the anabolic drive is triggered and muscle growth is stimulated. Unfortunately, so is bone and possibly organ growth in the viscera. This can lead to Acromegaly and Liver and/or Kidney damage with potentially fatal consequences.
These health risks are much reduced by age, Older individuals, having lower natural GH secretion levels, are likely to derive far more benefit from the use of exogenous HgH. This explains why a number of medical spas in Mexico and Europe are helping to reverse the the apparent signs of aging through the use of HgH.
Much more needs to be learned about the use of HgH for all types of individuals from young to old but it seems clear at this point that HgH does have an anabolic as well as ergogenic effect, albeit a risky one for most bodybuilders.
Our exploration now turns to the use of GH releasers. There are many substances that have been found to raise serum GH levels. What is rarely looked at in studies of the substrates or combinations of substrates is which hormone's levels are being raised and what ratios these elevated levels have to the other members of the group. It would appear that most GH releasing metabolites raise Somatotropin levels but with a corresponding increase in Somatostatin levels. This seems to produce a net wash in terms of anabolic drive but not in lipolytic drive. It is the observation of this phenomenon that leads me to strongly suspect that it is the action of another of the GH family that triggers the lipolytic effect. Strong suspicion falls to Somatomedin or Somatocrinin or more likely the balance between them.
Look at it this way, the ratio between Somatotropin and Somatostatin regulates the anabolic effect while the ratio between Somatomedin and Somatocrinin regulate the lipolytic effect. If this is true, and research will be required to prove it, then GH releasing combinations might be optimized for the desired effect. In the months to come, I'll be describing combinations of Over-the-Counter (OTC) supplements that will stimulate different GH ratios.
