Great anti-depression

[BigPapaPump]

For all you guys that get depressed after your cycles...I actually found some shit that works great for me.

I'm not coming off of a cycle but for the last few months I think I have worked and worried myself into a mild depression. My temper had gotten really bad with an attitude and rotten disposition to go with it. I went into Vitamin world the other day and grabbed some St. Johns Wort and SAM-e...I fugured what the hell.

It has worked absolute wonders ! I no longer have that 'funk' feeling and have alot more energy.

Just thought I'd pass this on. Normally I think that all this stuff is just junk.

BPP

 

[Mad Max]

Good shit man, I know what you mean about after a cycle, you have a clogged feeling in your head and you feel like shit. I'll deff. give that stuff a try. How much do you take, just the reccomended dosage?
---PEACE---Mad Max

 

[thx9000]

I've used SAM-E and 5-HTP before, they really help through the winters when for some reason I can never get motivated. Costco usually has great prices on SAM-E too, which is good b/c the stuff can be like $2/200mg at my local grocery store.

 

[macrophage69alpha]

INOSITOL

 

[Wombat]

placebo effect-----do enough research on depression and you will see studies done that saint johns wort is absolutly useless--------....sorry...

 

[waldo]

I have tried St. John Wort. Its helps the mood but damn that stuff made me really dizzy. Probably because of some ear infection.

 

[gimp]

I feel that St. John's Wort is effective fro mild depression or "the blues". I don't think that it's effective for major depressive symptoms. Germany is big on herbal treatments for mental illness and they prescribe Wort so often that it is covered by there health system. Studies show that it is effective as well, but keep in mind that most studies show that therapy is at least as effective as any anti-depressants over the long term.

 

[muscle_geek]

Sam-E does put me in a better mood when I take one pill daily, but if I take it before I go to bed, I get the most fucked up dreams imaginable.

 

[lawnsaver]

BigPapa, it isnt the St. Johns, it is the S-ame

The best combo in S-ame/5-htp/inositol

These 3 will work awsome!!

 

[casavant]

wellbutrin + adderall is a good one too.

 

[Sassy69]

I'm trying inositol -- i'lll update in a week or so. Inositol is hella cheaper than SAM-e too.

 

[Delinquent]

I'm trying inositol -- i'lll update in a week or so. Inositol is hella cheaper than SAM-e too.

Please do

 

[BigPapaPump]

Shit which ever is working, makes no difference. I'm not a big dick head anymore. The Sam-e must be laced with gold cause it was expensive. I think I'll just take this one box and see if I can stay out of the rotten moods. I must say that I've had the best nights sleep in years taking this stuff. That could be the cause of all my problems anyway...kinda hard to get a good nights sleep with new born in the house.

Macro....what the hell is the stuff you said ? Is it OTC ?

BPP

 

[Sassy69]

Update:

inositol - 3g/day (1.5g, 2x/day) - much better attitude about life. I got laid off 4 months ago and I'm looking at supporting a new BMW. Of course I'm depressed. But this stuff gets me up out of bed in the morning & keeps me upbeat. Also doing kava kava at night - was having trouble sleeping , like getting any at all -- not a problem any more.

 

[Briweve]

Here is some info I found.

Double-Blind, Controlled Trial of Inositol Treatment of Depression



Joseph Levine, M.D., Yoram Barak, M.D., Mirtha Gonzalves, M.D., Henry Szor, M.D., Avner Elizur, M.D., Ora Kofman, Ph.D., and R.H. Belmaker, M.D.

Received Aug. 26, 1993; revision received Feb. 3, 1994; accepted April 22, 1994. From the Yehuda Abarbanel Mental Health Center, Bat Yam, Israel; and the Ministry of
Health Mental Health Center, Faculty of Health Sciences and Depamnent of Behavioral Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Address reprint
requests to Dr. Belmaker, Beer-Sheva Mental Health Center, P.O. Box 4600, Beer-Sheva, Israel.

Supported by contract 263-MD-340-3442 from the NIMH New Medications Development Office.



OBJECTIVE: CSF levels of inositol have been reported to be lower than normal in depressed subjects. The authors administered inositol to depressed patients in a
double-blind, controlled trial. METHOD: Under double-blind conditions, 12 g/day of inositol (N=13) or placebo (N=25) was administered to depressed patients for 4 weeks.
RESULTS: The overall improvement in scores on the Hamilton Depression Rating Scale was significantly greater for inositol than for placebo at week 4. No changes were noted
in hematology or in kidney or liver function. CONCLUSIONS: This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in
treating depression. Although inositol had a significant antidepressant effect in this study, replication is crucial. (Am J Psychiatry 1995; 152:792-794)

Inositol is a simple isomer of glucose that is a key metabolic precursor in the phosphatidylinositol cycle. Unlike L-dopa and tryptophan, which are amino acid precursors of
monoamine neurotransmitters and which have been reported to have antidepressant properties, inositol is a precursor of an intracellular second messenger system. The
phosphatidylinositol cycle is a second messenger system for numerous neurotransmitters (1).

Barkai et al. (2) reported that depressed patients, both unipolar and bipolar, had markedly low levels of inositol in CSF. In an open study of 11 depressed patients who had been
resistant to previous antidepressant treatment (3), inositol treatment led to a decline in mean Hamilton Depression Rating Scale score from 31.7 (SD=6) to 16.2 (SD=9). Levine et
al. (4) showed that 12 g/day of inositol raised CSF inositol levels by 70%. We report here the results of administering 12 g/day of inositol to depressed patients in a double-blind,
controlled trial.

METHOD

The diagnostic entry criteria for the study were DSM-III-R major depression or bipolar disorder, depressed. Each of the patients who were referred to the study and gave
informed consent had not re- sponded to antidepressant treatment, had dropped out of treatment because of side effects, or, in the case of the bipolar depressed patients, were
lithium prophylaxis patients who had had few problems with mania but intolerable continuation of depression. All medications other than study drugs were stopped at least 3 days,
and usually 1 week, before the subjects entered the study. No medications other than inositol or placebo were permitted during the trial, except for oxazepam, up to 15 mg/day,
or an equivalent benzodiazepine if the patient had been taking it before the study. The study was approved by the Helsinki Committee institutional review board and the Ministry of
Health. Each patient gave written informed consent before participation.

Thirty-nine patients entered the trial. Of these, 11 dropped out within 1 week of starring the trial. Four of these patients were taking placebo, and their reasons for dropping out,
respectively, were headache, hypomania, insomnia, and lack of desire to continue in the study. Seven patients taking inositol dropped out within 1 week; two had mild psychotic
symptoms, one had weakness and tremor, one had a cutaneous burning sensation, and three did not want to continue in the study. These 11 patients are not included in the data
analysis. One patient taking inositol dropped out after 3 weeks because of total remission of symptoms, and her 2-week score was used as a last value carried forward.