Grapefruit Juice and Orals

[Caper26]

Hey,

Someone posted one day to take grapefruit juice with all orals. Not a good idea. If you have looked into that particular medication and there is not an interaction, go for it. GF juice can intesify the effects of some meds but not a good idea to take with all orals unless you have checked into everyone. Grapefruit juice blocks special enzymes in the wall of the small intestine that actually destroys many medications and prevents their absorption into the body. Thus, smaller amounts of the drugs get into the body than are ingested. When the action of this enzyme is blocked, more of the drugs get into the body and the blood levels of these medications increase. This can lead to toxic side effects from the medications.

Like i said look in to the individual oral first because research has also shown it can increase the amount of drug being "studied" in the body. You don't want to waste any gear or effect any medications your on. Seperating medication and grapefruit juice a few hours is usually sufficent but the effects one glass of grapefruit juice can last longer than 24 hours in the body. Just a tip in case anyone was unaware. I did not include any references because this info can easily be found by all.

Glenn Petrie

 

[Ulter]

This is a steroid board. People take steroids here. They take GF juice to increase the blood levels of the steroids. GF juice only increases the blood levels of the drug. It doesn't make it more toxic. If taking more of the drug makes it toxic then you shouldn't use GF juice. That's about it.

 

[reaper99]

well said ulter.

 

[Caper26]

This is a steroid board. People take steroids here. They take GF juice to increase the blood levels of the steroids. GF juice only increases the blood levels of the drug. It doesn't make it more toxic. If taking more of the drug makes it toxic then you shouldn't use GF juice. That's about it.

Grapefruit reduces the effectiveness of some medications can you not read. Why are you responding if you did not read the post. It seems that steroid users use more then steroids IE. anti estrogens and AI's. I was simply saying that GF juice can reduce the effectivness of some drugs and to be carefull and look in to each one individually. You are not allowed to take grapefruit juice with many meds because they will not work ie. Cholesterol drugs. This is proven! Why are you arguing with a simply statement that just said to be carefull when taking Meds with GF and to look into any potential interactions. WOW i guess that was stupid of me. Sorry...lol

 

[Caper26]

Why does everyone take everything so personal. Ask any doctor about Grapefruit juice and they will tell you the same. I was no being smart or even sharing a wrong opinion just sharing a fact. If you want to ignore information that is fine but did you ever read those littel sheets that come with a script. Information is in there for a reason.

 

[Caper26]

It also interacts with Viagra and Cialis which many people on this board say they use. Just a heads up. no pun intended.

 

[krishna]

Grapefruit reduces the effectiveness of some medications can you not read. Why are you responding if you did not read the post. It seems that steroid users use more then steroids IE. anti estrogens and AI's. I was simply saying that GF juice can reduce the effectivness of some drugs and to be carefull and look in to each one individually. You are not allowed to take grapefruit juice with many meds because they will not work ie. Cholesterol drugs. This is proven! Why are you arguing with a simply statement that just said to be carefull when taking Meds with GF and to look into any potential interactions. WOW i guess that was stupid of me. Sorry...lol

Sounds like you're the one taking it personal bro.

 

[R1 Psycho]

well said ulter.

HUH?

Uhh,..what was well said?

 

[R1 Psycho]

Grapefruit reduces the effectiveness of some medications can you not read. Why are you responding if you did not read the post. It seems that steroid users use more then steroids IE. anti estrogens and AI's. I was simply saying that GF juice can reduce the effectivness of some drugs and to be carefull and look in to each one individually. You are not allowed to take grapefruit juice with many meds because they will not work ie. Cholesterol drugs. This is proven! Why are you arguing with a simply statement that just said to be carefull when taking Meds with GF and to look into any potential interactions. WOW i guess that was stupid of me. Sorry...lol

Bro im 100 % with you on this......Ulter usually has alot of informative posts and good comments but sometimes peeps from this board really need to chill!

Geez...drama

 

[Ulter]

I think that's you who isn't reading. Well mainly you just don't understand what you're posting. GF juice does not make chol drugs "not work", as you posted.

GF juice raises the blood levels of meds. There are two statin drugs that should not be overdosed. So like I said already, and you didn't read, "If taking more of the drug makes it toxic then you shouldn't use GF juice. That's about it."

 

[krishna]

Bro im 100 % with you on this......Ulter usually has alot of informative posts and good comments but sometimes peeps from this board really need to chill!

Geez...drama

Who needs to chill? It's not like Ulter is getting mad or out of hand, he's simply pointing something out in relation to the guys post. Nobody's getting uptight except you two.

 

[Caper26]

I think that's you who isn't reading. Well mainly you just don't understand what you're posting. GF juice does not make chol drugs "not work", as you posted.

GF juice raises the blood levels of meds. There are two statin drugs that should not be overdosed. So like I said already, and you didn't read, "If taking more of the drug makes it toxic then you shouldn't use GF juice. That's about it."

I was just saying the same thing basically that if it increases levels of the drug for some drugs more is not better, ultimately decreasing their effectivenss (doing what they are made to do) . I was not arguing with the steroid thing i am sure you know what you are talking about. I was just saying that people should look into the interactions with other drugs such as anti E's or what ever anyone is taking. Some times people are on more drugs for sides then they are steroids and since there are so many on the market i just though it would be a good idea to tell people to look in to it, be safe, and realize that all meds do not interact the same. There is nothing worth arguing over just trying to share some information thought some one else might be interested.

 

[Caper26]

Do you know if it interacts with clen? I think that would could be a bad one sides are bad enough with that stuff with out amplifying it. What about things like dostinex? Can you use GF juice to increase there effectiveness and would that mean that you would require a smaller dose?

 

[macrophage69alpha]

grapefruit juice generally raises blood levels of SOME drugs by inhibiting cyp3a4, drugs like statins(lovostatin and simvistatin), antiarrhythmic agents, immunosuppressive agents, protease inhibitors, calcium channel blockers as well as many anabolic steroids are metabolized by this enzyme.


caper26 is correct in that you should check to make sure that any other meds you are taking dont have a significant interaction with cyp3a4. Ulter is correct in that only if increasing plasma levels is toxic is it an issue and that this being a steroid board one of the primary concerns is making steroids more effective/bioavailable.

agree that this should not have gotten personal, not sure why it did.

 

[R1 Psycho]

grapefruit juice generally raises blood levels of SOME drugs by inhibiting cyp3a4, drugs like statins(lovostatin and simvistatin), antiarrhythmic agents, immunosuppressive agents, protease inhibitors, calcium channel blockers as well as many anabolic steroids are metabolized by this enzyme.


caper26 is correct in that you should check to make sure that any other meds you are taking dont have a significant interaction with cyp3a4. Ulter is correct in that only if increasing plasma levels is toxic is it an issue and that this being a steroid board one of the primary concerns is making steroids more effective/bioavailable.

agree that this should not have gotten personal, not sure why it did.

NOW THAT WAS WELL SAID......

R1...

 

[macrophage69alpha]

as a note- grapefruit juice has been found to inhibit cyp3a4 in the intestines for up to 72hrs (obviously less over time)

 

[Caper26]

as a note- grapefruit juice has been found to inhibit cyp3a4 in the intestines for up to 72hrs (obviously less over time)

Thanks for the input. Pretty interesting stuff. It is amazing how things as simlple as grapefruit juice or other things we put in our body and don't think much about, can have such an influence on our body. I read something before about St. Johns wart interacting with medications. This is something i see in more and more products such as special teas and energy drinks. Are many drug metabolized by cyp3a4? I have read that St. John's wort should be used with caution by patients taking drugs metabolized by CYP3A4. Should this compound be avoided when taking steroids i am thinking yes but not totally sure. In knowledege on this Macro?


St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
Linda B. Moore*, Bryan Goodwin*, Stacey A. Jones*, G. Bruce Wisely*, Cosette J. Serabjit-Singh, Timothy M. Willson, Jon L. Collins, and Steven A. Kliewer