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Bromocriptine
This semi-synthetic derivative of the ergo group of ergot alkaloids is a dopamine receptor agonist, (for those who like precise detail it is a potent D2 agonist but also displays partial action on D1 receptors), as well as being a prolactin inhibitor.
Details of Bromocriptine can be seen at:
<http://www.antiaging-systems.com/a2z/bromocriptine.htm>
Bromocriptine's first major anti-aging use is the enhancement of Dopamine, (a key brain neurotransmitter that undergoes an age-related decline). Past the age of 40 it is estimated that “on-average” the healthy person undergoes a Dopamine decline of approximately 13% per decade, (Ward, Fowkes & Morgenthaler). Accordingly, some Neurologists have stated that; “if we all live long enough we shall all become senile.” This is due to the fact that abnormally low levels of Dopamine, (70% to 80% loss) are then diagnosed as Parkinson's disease, hence protection and enhancement of the Dopamine producing neurons is a key strategy for anti-aging medicine. Not surprisingly then, Bromocriptine is used in conjunction with other drugs, (such as Deprenyl and Sinemet) in the management of Parkinson's disease, but anti-aging medicine considers its preventative properties too.
Details about Deprenyl can be viewed at:
<http://www.antiaging-systems.com/a2z/deprenyl.htm>
Details about Sinemet can be viewed at:
<http://www.antiaging-systems.com/a2z/sinemet.htm>
Bromocriptine's second major anti-aging use is the inhibition of Prolactin, this hormone is one of the few that actually appears to increase with age. Prolactin is produced by the pituitary gland and its release is inhibited by Bromocriptine.
Prolactin has been described as a “fat synthesis hormone” because one of its primary functions is to trigger lactation, (milk production) and weight gain in pregnancy. In women, Bromocriptine has been used to help restore ovulation, but it also helps to reduce serum Prolactin levels in men, (although the precise role of Prolactin in men is unclear).
A further possible need to control age-related Prolactin levels is offered by some researchers who believe that Prolactin is an immune system suppressant.
Bromocriptine also affects the most famous of all pituitary hormones- Growth Hormone (GH). Bromocriptine increases GH secretion in individuals with low or normal GH concentrations, but paradoxically suppresses GH secretion in some patients with acromegaly, (a condition of excessive-production of GH). Studies indicate that Bromocriptine does not affect the release of any other anterior pituitary hormones.
Due to its Dopamine enhancement, Bromocriptine has even been cited as an aphrodisiac, although little effort has been made to study and confirm this action. There have been several reports of “better controlled” orgasms and “almost orgasms” before the real orgasm occurs. If any countries allow for more medical categories such as “weak orgasm syndrome” or perhaps, “clinical sex-drive loss” then Dopamine agonists such as Bromocriptine are going to receive a lot of attention from the pharmaceutical manufacturers, especially in the wake of Viagra (r) sales.
Another interesting clinical study administered a component of tobacco called DMBA to rats at a level where it is known to be very effective in producing breast cancer. However, rats that had been pretreated with Bromocriptine completely avoided any cancer development. Bromocriptine therefore appears to also offer itself as a very potent free radical quencher.
One of the most recent studies indicates that Bromocriptine may be a candidate for the treatment of Type-2 diabetes. This is because Bromocriptine has been shown to suppress lipogenesis and improve glucose tolerance and insulin resistance.
One animal study suggested that a further action of Bromocriptine is to alter CNS (central nervous system), regulating metabolism and as such, has another important use in helping to prevent weight gain, (this would be in addition to its improvement of diabetic conditions).
Dosages, Side Effects and Contraindications
Bromocriptine is a very potent substance and it must not be used by pregnant or lactating women unless under the guidance of a physician. Side effects include nausea, dizziness, lowering of blood pressure, hypotension and confusion. The first three are relatively common, especially when undertaking initial use. It is also known to increase fertility, and thus “extra care” and contraception is advised where necessary.
To see the approved uses for this product, including side-effects and contraindications, please use the following link:
<http://www.antiaging-systems.com/apruses/bromocriptine.htm>
Bromocriptine can contraindicate with psychoactive and hypotensive drugs and other Dopamine enhancing drugs, (such as Deprenyl and Sinemet etc.,) should only be administered concurrently under a physician's guidance. Its effects can also be exaggerated when combined with other ergots including Hydergine and Nicergoline.
This semi-synthetic derivative of the ergo group of ergot alkaloids is a dopamine receptor agonist, (for those who like precise detail it is a potent D2 agonist but also displays partial action on D1 receptors), as well as being a prolactin inhibitor.
Details of Bromocriptine can be seen at:
<http://www.antiaging-systems.com/a2z/bromocriptine.htm>
Bromocriptine's first major anti-aging use is the enhancement of Dopamine, (a key brain neurotransmitter that undergoes an age-related decline). Past the age of 40 it is estimated that “on-average” the healthy person undergoes a Dopamine decline of approximately 13% per decade, (Ward, Fowkes & Morgenthaler). Accordingly, some Neurologists have stated that; “if we all live long enough we shall all become senile.” This is due to the fact that abnormally low levels of Dopamine, (70% to 80% loss) are then diagnosed as Parkinson's disease, hence protection and enhancement of the Dopamine producing neurons is a key strategy for anti-aging medicine. Not surprisingly then, Bromocriptine is used in conjunction with other drugs, (such as Deprenyl and Sinemet) in the management of Parkinson's disease, but anti-aging medicine considers its preventative properties too.
Details about Deprenyl can be viewed at:
<http://www.antiaging-systems.com/a2z/deprenyl.htm>
Details about Sinemet can be viewed at:
<http://www.antiaging-systems.com/a2z/sinemet.htm>
Bromocriptine's second major anti-aging use is the inhibition of Prolactin, this hormone is one of the few that actually appears to increase with age. Prolactin is produced by the pituitary gland and its release is inhibited by Bromocriptine.
Prolactin has been described as a “fat synthesis hormone” because one of its primary functions is to trigger lactation, (milk production) and weight gain in pregnancy. In women, Bromocriptine has been used to help restore ovulation, but it also helps to reduce serum Prolactin levels in men, (although the precise role of Prolactin in men is unclear).
A further possible need to control age-related Prolactin levels is offered by some researchers who believe that Prolactin is an immune system suppressant.
Bromocriptine also affects the most famous of all pituitary hormones- Growth Hormone (GH). Bromocriptine increases GH secretion in individuals with low or normal GH concentrations, but paradoxically suppresses GH secretion in some patients with acromegaly, (a condition of excessive-production of GH). Studies indicate that Bromocriptine does not affect the release of any other anterior pituitary hormones.
Due to its Dopamine enhancement, Bromocriptine has even been cited as an aphrodisiac, although little effort has been made to study and confirm this action. There have been several reports of “better controlled” orgasms and “almost orgasms” before the real orgasm occurs. If any countries allow for more medical categories such as “weak orgasm syndrome” or perhaps, “clinical sex-drive loss” then Dopamine agonists such as Bromocriptine are going to receive a lot of attention from the pharmaceutical manufacturers, especially in the wake of Viagra (r) sales.
Another interesting clinical study administered a component of tobacco called DMBA to rats at a level where it is known to be very effective in producing breast cancer. However, rats that had been pretreated with Bromocriptine completely avoided any cancer development. Bromocriptine therefore appears to also offer itself as a very potent free radical quencher.
One of the most recent studies indicates that Bromocriptine may be a candidate for the treatment of Type-2 diabetes. This is because Bromocriptine has been shown to suppress lipogenesis and improve glucose tolerance and insulin resistance.
One animal study suggested that a further action of Bromocriptine is to alter CNS (central nervous system), regulating metabolism and as such, has another important use in helping to prevent weight gain, (this would be in addition to its improvement of diabetic conditions).
Dosages, Side Effects and Contraindications
Bromocriptine is a very potent substance and it must not be used by pregnant or lactating women unless under the guidance of a physician. Side effects include nausea, dizziness, lowering of blood pressure, hypotension and confusion. The first three are relatively common, especially when undertaking initial use. It is also known to increase fertility, and thus “extra care” and contraception is advised where necessary.
To see the approved uses for this product, including side-effects and contraindications, please use the following link:
<http://www.antiaging-systems.com/apruses/bromocriptine.htm>
Bromocriptine can contraindicate with psychoactive and hypotensive drugs and other Dopamine enhancing drugs, (such as Deprenyl and Sinemet etc.,) should only be administered concurrently under a physician's guidance. Its effects can also be exaggerated when combined with other ergots including Hydergine and Nicergoline.
