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GH: why do 5 on, 2 off?
- Thread starter Ercole
- Start date
ItalianSta
New member
I belive it is just for money saving . A sero kit will last 1 month with a dose of 6iu .
Here is your a post from last week of exactly the same question, hope it helps:
http://209.11.101.244/forum/showthread.php?threadid=66615&highlight=gh
http://209.11.101.244/forum/showthread.php?threadid=66615&highlight=gh
diamonddiceclay
New member
the pituitary needs the 2 days off to function
No, supplementing with exogenous GH does not shut down the pituitary. The body's defense mechanisms will reduce GH production only during the time period immediately after the injection, for 2 to 4 hours. Same with insulin.
Only reason for the 5/2 split is economics.
Only reason for the 5/2 split is economics.
Medical cite on gh suppression
At some point, exogenous gh will suppress your own gh production, but at what level? This cite sheds some light.
If .88 free IGF-1 correlates to a normal young person's gh level,
then increasing it to 2.1, a 240% increase, means that that person
would shut down 75% of gh internal production. So if the normal IGF-
1 level for that group in the study is about 250, increasing it to
600 would shut down 75% of internal gh production. Still, the
pituitary is producing some gh and it doesn't shut down completely.
However, it does show that when you start getting pretty high in the
IGF-1 (probably around 500-600), injected gh will start replacing a
significant portion of your internal gh.
"Recovery of Growth Hormone Release from Suppression by Exogenous
Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive
Action of Free Rather Than Bound IGF-I
The Journal of Clinical Endocrinology & Metabolism Vol. 83, No. 8
2836-2842
Ian M. Chapman2, Mark L. Hartman, Karen S. Pieper, Emily H. Skiles,
Suzan S. Pezzoli, Raymond L. Hintz and Michael O. Thorner
To determine the time course of recovery of GH release from insulin-
like growth factor I (IGF-I) suppression, 11 healthy adults (18–29
yr) received, in randomized order, 4-h iv infusions of recombinant
human IGF-I (rhIGF-I; 3 µg/kg·h) or saline (control) from 25.5–29.5 h
of a 47.5-h fast. Serum GH was maximally suppressed within 2 h and
remained suppressed for 2 h after the rhIGF-I infusion; during this 4-
h period, GH concentrations were approximately 25% of control day
levels [median (interquartile range), 1.2 (0.4–4.0) vs. 4.8 (2.8–7.9)
µg/L; P < 0.05]. A rebound increase in GH concentrations occurred 5–7
h after the end of rhIGF-I infusion [7.6 (4.6–11.7) vs. 4.3 (2.5–6.0)
µg/L; P < 0.05]. Thereafter, serum GH concentrations were similar on
both days. Total IGF-I concentrations peaked at the end of the rhIGF-
I infusion (432 ± 43 vs. 263 ± 44 µg/L; P < 0.0001) and remained
elevated 18 h after the rhIGF-I infusion (360 ± 36 vs. 202 ± 23 µg/L;
P = 0.001). Free IGF-I concentrations were approximately 140% above
control day values at the end of the infusion (2.1 ± 0.4 vs. 0.88 ±
0.3 µg/L; P = 0.001), but declined to baseline within 2 h after the
infusion. The close temporal association between the resolution of GH
suppression and the fall of free IGF-I concentrations, and the lack
of any association with total IGF-I concentrations suggest that
unbound (free), not protein-bound, IGF-I is the major IGF-I component
responsible for this suppression. The rebound increase in GH
concentrations after the end of rhIGF-I infusion is consistent with
cessation of an inhibitory effect of free IGF-I on GH release."
At some point, exogenous gh will suppress your own gh production, but at what level? This cite sheds some light.
If .88 free IGF-1 correlates to a normal young person's gh level,
then increasing it to 2.1, a 240% increase, means that that person
would shut down 75% of gh internal production. So if the normal IGF-
1 level for that group in the study is about 250, increasing it to
600 would shut down 75% of internal gh production. Still, the
pituitary is producing some gh and it doesn't shut down completely.
However, it does show that when you start getting pretty high in the
IGF-1 (probably around 500-600), injected gh will start replacing a
significant portion of your internal gh.
"Recovery of Growth Hormone Release from Suppression by Exogenous
Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive
Action of Free Rather Than Bound IGF-I
The Journal of Clinical Endocrinology & Metabolism Vol. 83, No. 8
2836-2842
Ian M. Chapman2, Mark L. Hartman, Karen S. Pieper, Emily H. Skiles,
Suzan S. Pezzoli, Raymond L. Hintz and Michael O. Thorner
To determine the time course of recovery of GH release from insulin-
like growth factor I (IGF-I) suppression, 11 healthy adults (18–29
yr) received, in randomized order, 4-h iv infusions of recombinant
human IGF-I (rhIGF-I; 3 µg/kg·h) or saline (control) from 25.5–29.5 h
of a 47.5-h fast. Serum GH was maximally suppressed within 2 h and
remained suppressed for 2 h after the rhIGF-I infusion; during this 4-
h period, GH concentrations were approximately 25% of control day
levels [median (interquartile range), 1.2 (0.4–4.0) vs. 4.8 (2.8–7.9)
µg/L; P < 0.05]. A rebound increase in GH concentrations occurred 5–7
h after the end of rhIGF-I infusion [7.6 (4.6–11.7) vs. 4.3 (2.5–6.0)
µg/L; P < 0.05]. Thereafter, serum GH concentrations were similar on
both days. Total IGF-I concentrations peaked at the end of the rhIGF-
I infusion (432 ± 43 vs. 263 ± 44 µg/L; P < 0.0001) and remained
elevated 18 h after the rhIGF-I infusion (360 ± 36 vs. 202 ± 23 µg/L;
P = 0.001). Free IGF-I concentrations were approximately 140% above
control day values at the end of the infusion (2.1 ± 0.4 vs. 0.88 ±
0.3 µg/L; P = 0.001), but declined to baseline within 2 h after the
infusion. The close temporal association between the resolution of GH
suppression and the fall of free IGF-I concentrations, and the lack
of any association with total IGF-I concentrations suggest that
unbound (free), not protein-bound, IGF-I is the major IGF-I component
responsible for this suppression. The rebound increase in GH
concentrations after the end of rhIGF-I infusion is consistent with
cessation of an inhibitory effect of free IGF-I on GH release."
This supports my statement precisely.
diamonddiceclay
New member
www.ugsupplements.com says that the pituitary needs the 2 days off for normal function
21inch_arms
New member
diamonddiceclay said:
Regarding the site you are refering to where is the study? I have taken GH for extended amounts of time (6+ months @ 4-6iu per day) without using a 5 on 2 off regemen and have never experienced problems with the pituitary shutting down. I get checked before, during, and after.
diamonddiceclay
New member
it is in 1 of their early issues where they covered HGH
If it were true that the pituitary shuts down hgh production after a while of injecting it, then the IGF-1 would start out high, and then decline over time. This does not happen at the doses I am taking (3 IU/day for the last 1 1/2 years). I have half dozen IGF-1 lab test that show this.
Last edited:
If you take one day off/one day on, your average IGF-1 will be lower. It's the same as taking half the dose every day.
3 IU/day is not a waste of either time or money to me. I know some people take 4-8/day for a few months. But I have also seen that the effects of hgh are cumulative. The effects are very small from day to day or week to week. But over a longer period of time, the effect is huge. It does much more than help lose fat and spare the muscle. It affects the body at a cellular level and does some things nothing else can. I'm keeping my IGF-1 at about 450 ALL the time.
3 IU/day is not a waste of either time or money to me. I know some people take 4-8/day for a few months. But I have also seen that the effects of hgh are cumulative. The effects are very small from day to day or week to week. But over a longer period of time, the effect is huge. It does much more than help lose fat and spare the muscle. It affects the body at a cellular level and does some things nothing else can. I'm keeping my IGF-1 at about 450 ALL the time.
You don't save any money. For a given gh level, it costs x dollars, whether or not you cycle it. So you could do 4 IU/day 5 on 2 off (20IU/week) or you could do 2.85 IU/day every day (20 IU/week). It costs the same and your gh levels should average out about the same. Maybe a bit more highs and lows with the cycling.
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