Carth said:
How does GH work? What exactly is the purpose of GH? I know very well how Test and Estro and all those other hormones work and what they do. But what about GH? I mean...if all my hormones were Ok. But my GH was low. Is this bad? What would happen? Here is the reason why I am asking this. I stopped taking my HRT GH for about 6 weeks. I just wanted to see what would happen. And honestly...nothing bad happend! I didnt' gain any fat! I didn't loose any sleep! My libido was fine. If anything I did notice that I lost some water and looked more leaner and vascular.
I'm having problems now with my insurance company. And they might take away my GH Hrt. I dont' know if I should be worried or not if I get my GH. I know 6 weeks of not taking it didn't do anything bad to me. But what about now years of not taking it! What will happen?
HOW DOES HGH DO ITS WORK?
HGH is short lived, but during its short half-hour or so activity per burst from the pituitary, it exerts itself through direct and indirect effects.
Its direct effects are the result of the HGH binding its receptor on target cells. Fat cells (adipocytes) as well as myocytes (muscle cells) have HGH receptors. On fat cells, HGH stimulates them to break down triglyceride and suppresses the fat cells ability to uptake circulating lipids.
Its indirect effects are in the process we described in the section above. When HGH travels to the liver, the result in its pass through the liver is the secretion of IGF-1. When this IGF-1 is secreted, it stimulates proliferation of chondrocytes (cartilage cells), which result in bone growth. It also plays a part in stimulating both the proliferation and differentiation of myoblasts (the precursor to skeletal muscle fibers). IGF-1 also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
HGH stimulates protein anabolism in many tissues. This reflects increased protein synthesis, decreased oxidation of proteins, and increased amino acid uptake. As mentioned above, HGH enhances fat utilization by stimulating triglyceride breakdown and oxidation in fat cells (adipocytes).
HGH can affect the function of other hormones. HGH can suppress the abilities of insulin to stimulate the uptake of glucose in tissues and enhance glucose synthesis in the liver, though administering HGH actually stimulates insulin secretion and can create a state of hyperinsulinemia. This combination can lead to decreased insulin sensitivity, which in turn can lead to hyperglycemia. HGH can also have a slight inhibitory effect on the thyroid, though this varies greatly from individual to individual. We’ll discuss more on how to deal with these potential effects later in this guide.
Okay, so we have a hormone that can assist with maintenance and healing of most of the body’s systems, can create new cartilage, bone, and muscle cells, can assist with protein uptake, decrease the oxidation of proteins, and can accelerate the rate at which fat is utilized. This paints the picture of the excitement that follows HGH. So how do we utilize this to our advantage? Let’s look at what is involved in exogenous HGH use.
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