In my experience that I've seen it depends If your an out of shape 250 and never did a cycle before you should be able to do the same cycle as some one lighter with results, you also have to figure that if you do a cycle cut up a little bit put on say 35lbs being that your already big you may not feel there as good as someone else because lets face it where going to notice someones thats 150 all of a sudden shooting up to 200lbs.Bottom line a 250lb person if its your first cycle theres no need to over do it just because of your weight. hope this helps a little bit..