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Aged garlic extract reduces
heart disease risk factors
Aged garlic extract (Kyolic) can potentially cut the risk of heart attack by its dramatic reduction of major risk factors for heart disease. This breakthrough that can help save lives was reported to the media in late February by the Research and Education Institute (REI) at Harbor-UCLA Medical Center, where the study took place. The report showed that daily consumption of Kyolic aged garlic extract inhibited atherosclerotic plaque formation in coronary arteries of cardiac patients and reduced blood homocysteine, another risk factor for cardiovascular disease. The study will be presented at the meetings of the Federation of the American Societies for Experimental Biology in San Diego on April 15, 2003.
The placebo-controlled, double blinded clinical trial, lead by Dr. Matthew Budoff, investigated over a year whether aged garlic extract alters the rate of plaque formation in coronary arteries of patients with heart disease, who were on cholesterol-lowering statin medication. Nineteen patients with an average age of 59 participated in the complete study. Nine ingested 4 ml/day (1200 mg/day) Kyolic aged garlic extract, while 10 ingested a placebo. Electron beam tomography (EBT), a non-invasive procedure, served to determine arthrosclerotic plaque progression by measuring calcium deposits (calcification) in coronary arteries. Increased calcification correlates with plaque build-up and indicates an active development of atherosclerotic plaques that can trigger heart attacks.
At year's end, the results were striking. Kyolic aged garlic extract reduced coronary artery plaque build-up by more than 50%, compared to placebo. The garlic extract lowered blood homocysteine, while patients on placebo showed an increase; aged garlic extract also improved high density lipoproteins (HDL, the good cholesterol).
Made from organically grown garlic, by a standardized extraction and aging process, the odorless Kyolic aged garlic extract retains garlic nutrients and is rich in antioxidants that play a role in protecting blood vessel walls from atherosclerosis. The process of extraction and aging produces healthful water-soluble organosulfur compounds, such as S-allyl cysteine, and converts harsh volatile compounds, such as allicin, to stable beneficial substances.
The UCLA study adds new critical information to the body of data showing that aged garlic extract reduces multiple risk factors associated with heart disease. These include blood thinning (by inhibiting platelet aggregation and adhesion), a lowering of blood pressure, stimulation of blood circulation in capillaries, reduction of LDL (the bad cholesterol) and triglycerides levels and inhibition of LDL oxidation (oxidized LDL promotes plaques).
Although the study was small, its striking results on coronary artery protection by aged garlic extract, even in people with heart disease, is hopeful news for those at high risk for heart attacks. Aged garlic extract can be added to other routine medications for heart disease-such as statins-without side effects, potentially enhancing treatment and helping to postpone the need for cardiac surgery. As for healthy people, the study suggest that adding aged garlic extract to the diet would provide a preventive strategy against atherosclerosis and help maintain a healthy heart.
- Carmia Borek, Ph.D.
Medical patents prove the benefits of
Aged garlic extract reduces
heart disease risk factors
Aged garlic extract (Kyolic) can potentially cut the risk of heart attack by its dramatic reduction of major risk factors for heart disease. This breakthrough that can help save lives was reported to the media in late February by the Research and Education Institute (REI) at Harbor-UCLA Medical Center, where the study took place. The report showed that daily consumption of Kyolic aged garlic extract inhibited atherosclerotic plaque formation in coronary arteries of cardiac patients and reduced blood homocysteine, another risk factor for cardiovascular disease. The study will be presented at the meetings of the Federation of the American Societies for Experimental Biology in San Diego on April 15, 2003.
The placebo-controlled, double blinded clinical trial, lead by Dr. Matthew Budoff, investigated over a year whether aged garlic extract alters the rate of plaque formation in coronary arteries of patients with heart disease, who were on cholesterol-lowering statin medication. Nineteen patients with an average age of 59 participated in the complete study. Nine ingested 4 ml/day (1200 mg/day) Kyolic aged garlic extract, while 10 ingested a placebo. Electron beam tomography (EBT), a non-invasive procedure, served to determine arthrosclerotic plaque progression by measuring calcium deposits (calcification) in coronary arteries. Increased calcification correlates with plaque build-up and indicates an active development of atherosclerotic plaques that can trigger heart attacks.
At year's end, the results were striking. Kyolic aged garlic extract reduced coronary artery plaque build-up by more than 50%, compared to placebo. The garlic extract lowered blood homocysteine, while patients on placebo showed an increase; aged garlic extract also improved high density lipoproteins (HDL, the good cholesterol).
Made from organically grown garlic, by a standardized extraction and aging process, the odorless Kyolic aged garlic extract retains garlic nutrients and is rich in antioxidants that play a role in protecting blood vessel walls from atherosclerosis. The process of extraction and aging produces healthful water-soluble organosulfur compounds, such as S-allyl cysteine, and converts harsh volatile compounds, such as allicin, to stable beneficial substances.
The UCLA study adds new critical information to the body of data showing that aged garlic extract reduces multiple risk factors associated with heart disease. These include blood thinning (by inhibiting platelet aggregation and adhesion), a lowering of blood pressure, stimulation of blood circulation in capillaries, reduction of LDL (the bad cholesterol) and triglycerides levels and inhibition of LDL oxidation (oxidized LDL promotes plaques).
Although the study was small, its striking results on coronary artery protection by aged garlic extract, even in people with heart disease, is hopeful news for those at high risk for heart attacks. Aged garlic extract can be added to other routine medications for heart disease-such as statins-without side effects, potentially enhancing treatment and helping to postpone the need for cardiac surgery. As for healthy people, the study suggest that adding aged garlic extract to the diet would provide a preventive strategy against atherosclerosis and help maintain a healthy heart.
- Carmia Borek, Ph.D.
Medical patents prove the benefits of
