It'll happen with tren any time it rapidly gets into the blood stream. Large volume that leeches out of the muscle when injecting, going through a vein, injecting into a vein. Homebrew, ug, or lab gear(althugh I don't think any legit labs make tren), it does not matter.
I did 4cc, mixed gear(1cc tren), and when almost done, I got the cough for the 2nd time. Just too much volume. A drop of gear spilled out the site when I pulled out the pin.