Some E users will engage in 'plunging', where they actually stick the E-pill in their ass, like a suppository. That would get around the digestion, if you're the type of guy who likes to put things in his ass. (Nothing against those who do.)
...but keep something in mind. Unless you're a chemist and manufacture the E yourself, you have no idea what it's been cut with before pressing the pills, or what else may be in it. The liver is going to help out with detoxifying whatever you get along with the E in your pill. If you shoot it, snort it, put it in your ass, or whatever... you're not going to have that extra bit of protection.