ECA stack importance of the A

[canada48]

ive used ephedrine and caffeine together to aid fatloss. This time i was going to throw in Aspirin just to see if it makes any difference. I was on another board just reading around and i came across this:

Aspirin is a COX-2 inhibitor, in short, it prevents prostoglandins from being synthesized and prostoglandins are the messangers to begin protein synthesis.

this basically says aspirin inhibits protein synthesis. Is there any truth to this?

 

[crulexis]

I think hundreds of bodybuilders would disagree with you, but not exactly sure for what reasons..
I know that taking a LOW DOSE aspirin actually thins the blood quite safely, which is good.. Taking too much can be bad for the liver though.

EH!?...lol

 

[the.gladiator1987]

I did it without aspirin and i had crazy energy and lost fat

 

[OrbitNutrition.com]

ibuprofen inhibits protein synthesis.

Aspirin is included in the ECA stack to help prolong the effects of ephedrine. Basically as a normalizing procedure the body reacts to ephedrine by producing prostaglandins and adenosine outside the cell, and phosphodiesterase inside the cell. Inside the cell, it has been found that methylxanthines, like caffeine, inhibit the activities of phosphodiesterase. Stimulation of the beta receptors by ephedrine (via noradrenaline) causes an increase of cAMP (cyclic adenosine monophosphate) within the cell. This crucial part of the process that leads to thermogenesis is vulnerable because cAMP is degraded by phosphodiesterase. Outside the cell, aspirin inhibits the peripheral synthesis of prostaglandins. Prostaglandins inhibit the release of noradrenaline in the synaptic junction (before receptor stimulation). So in other words without aspirin (and caffeine), the beta agonistic qualities of ephedrine (via noradrenaline) are practically negated by prostaglandins. Thermogenesis is prolonged because aspirin interferes with this negative feedback mechanism

 

[toniportray]

Well said Orbit. I've never actually noticed any thermogenic difference with/without the Aspirin though, as most probably agree.

 

[OrbitNutrition.com]

yeah me either, it helped when i platued during my contest cut adding in the asprin but other than that its no biggie imho.

 

[mrplunkey]

I was going to do a post on this as swell.

I'm a huge lipostim fan, but adding one baby aspirin per day seems to make it work even better.