durabolin shutdown

[tournesol]

Could it work to use a very small amount of test the last two weeks in a Durabolin cycle only to prevent a hard shutdown ? I'm using Nolvadex postcycle......

 

[dali]

I got shut down hard last time I did NPP (Durabolin). Had limp dick for 2mths. I was taking 700mg per wk along with 700mg Test Prop. The test didn't help me out, it might for you.
cheers from China

 

[lartinos]

This is why I use my tren at the beginning of my cycles. Run it longer and try to keep onto your gains

 

[Animal]

That's why you'd use tren or deca or 19nors at the beginning of a cycle.

High dose anabolic androgenic steroids modulate concentrations of nerve growth factor and expression of its low affinity receptor (p75 NGFr) in male rat brain.
Author
Tirassa P; Thiblin I; Agren G; Vigneti E; Aloe L; Stenfors C
Address
Institute of Neurobiology, C.N.R., Rome, Italy.
Source
J Neurosci Res, 47(2):198 207 1997 Jan 15
Abstract
The effects of treatment with a high dose of nandrolone or testosterone on nerve growth factor (NGF) levels and NGF low affinity receptor (p75 NGFr) distribution in the brain were analyzed.
Nandrolone, subcutaneously injected in rats for several weeks, caused an increase of NGF levels in the hippocampus and septum and a decrease in the hypothalamus. The number of p75 NGFr immunoreactive neurons and the p75 NGFr expression levels were reduced
in the septum and vertical and horizontal Broca's bands.

Testosterone injections caused an increase of NGF levels in the hippocampus, septum, and occipital cortex and induced an upregulation of p75 NGFr in the forebrain NGF target regions.

This testosterone effect suggests that nandrolone and testosterone affect brain NGF target cells by a different mechanism(s). Nandrolone may interfere with NGF transport and/or utilization by forebrain neurons, causing an altered p75 NGFr expression and NGF accumulation as a consequence. Since NGF is known to maintain forebrain neurons and to regulate neurobehavioral functions, including memory, learning, and defensive behavior, it is possible to hypothesize that this neurotrophin may play a role in the mechanism of action of anabolic androgenic steroids (AAS) in the brain and be associated with endocrine and behavioral dysfunctions occurring due to AAS abuse.