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DeepZenPill
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I wonder what Nelson thinks about the Nolvadex suggestion. There's a situation where it can be beneficial for HEALTH to run an anti-e.
DRveejay's Comprehensive ASSAULT on Cholesterol!
- Thread starter drveejay11
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geoboy
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Lycopene
VJ
here's a study on beneficial effects of Lycopene. Sounds similar to the substitue-HDL use of Garlic:
----
Lycopene Shown to Block Early Signs of Atherosclerosis
Source: Tufts University
February 14, 2003
One of the nutrients currently getting a lot of attention for its potential role in reducing the risk of cardiovascular disease is lycopene - the pigment that gives tomatoes their characteristic red color. A new study from Finland that furthers what we know of this diet-disease connection was recently published in the American Journal of Clinical Nutrition.
Data used in this cross-sectional analysis were collected on 1028 participants of an ongoing study of cardiovascular risk factors in a population of middle-aged men. Mean and maximal intima-media thickness of the common carotid artery (CCA-IMT) were measured by means of high-resolution ultrasound. The researchers also recorded serum levels of lycopene, beta-carotene, and vitamin E, resting blood pressure, body mass index (BMI), and smoking status for all participants.
The men were divided into quartiles according to serum lycopene status, which ranged from a low of <0.04 µmol/L to a high of >0.22 µmol/L. After adjusting for potential confounders - including age, smoking status, serum levels of vitamin E and beta-carotene, and serum lipid profile - the researchers found an inverse correlation between serum lycopene levels and both mean and maximal CCA-IMTs (p values for trend = 0.039 and 0.013, respectively). Further analysis showed that the effect was more pronounced in smokers than in non-smokers. Mean and maximal CCA-IMT measurements were about 10% higher in smokers in the lowest quartile when compared with other participants who smoked.
]Proposed mechanisms
The results of this study mirror those of the Rotterdam Study, which associated high serum lycopene status with a reduced risk of aortic atherosclerosis. As is the case with other antioxidant nutrients, lycopene may cut heart disease risk by inhibiting the oxidation of LDL cholesterol particles, reducing lipid peroxidation and slowing the progression of arterial damage. Additionally, in vitro studies have shown that lycopene effectively suppresses adhesion of monocytes to endothelial cells.
Diet as part of a healthy lifestyle
It is worth noting that the men in the highest lycopene quartile had markedly better health profiles than others in the study. On average, they had higher serum levels of vitamin E, folate, and beta-carotene. They were less likely to smoke, and had a lower average BMI and blood pressure when compared with those in the lowest quartile of serum lycopene level. All of these factors - in combination with favorable lycopene status - probably contributed to the better outcomes recorded in this study.
Advice to patients
The key point of this current analysis is that lower serum lycopene levels were associated with narrowing and thickening of the lining of the carotid artery, an early sign of atherosclerosis that would not likely be detected outside of a clinical setting.
The message is clearly one of prevention rather than cure. A diet that provides a variety of antioxidant-rich fruits and vegetables - including tomatoes - appears to help slow the progression of arterial changes that ultimately results in heart disease.
(Note: the bioavailability of lycopene is higher in cooked tomato products than in fresh tomatoes. So, good choices for readily available lycopene are products like spaghetti sauce, pizza, and other foods that include cooked tomato.)
Source
Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. T. Rissanen, S. Voutilainen, K. Nyyssönen, et al., Amer J Clin Nutr, 2003, vol. 77, pp. 133--138xxxxx
VJ
here's a study on beneficial effects of Lycopene. Sounds similar to the substitue-HDL use of Garlic:
----
Lycopene Shown to Block Early Signs of Atherosclerosis
Source: Tufts University
February 14, 2003
One of the nutrients currently getting a lot of attention for its potential role in reducing the risk of cardiovascular disease is lycopene - the pigment that gives tomatoes their characteristic red color. A new study from Finland that furthers what we know of this diet-disease connection was recently published in the American Journal of Clinical Nutrition.
Data used in this cross-sectional analysis were collected on 1028 participants of an ongoing study of cardiovascular risk factors in a population of middle-aged men. Mean and maximal intima-media thickness of the common carotid artery (CCA-IMT) were measured by means of high-resolution ultrasound. The researchers also recorded serum levels of lycopene, beta-carotene, and vitamin E, resting blood pressure, body mass index (BMI), and smoking status for all participants.
The men were divided into quartiles according to serum lycopene status, which ranged from a low of <0.04 µmol/L to a high of >0.22 µmol/L. After adjusting for potential confounders - including age, smoking status, serum levels of vitamin E and beta-carotene, and serum lipid profile - the researchers found an inverse correlation between serum lycopene levels and both mean and maximal CCA-IMTs (p values for trend = 0.039 and 0.013, respectively). Further analysis showed that the effect was more pronounced in smokers than in non-smokers. Mean and maximal CCA-IMT measurements were about 10% higher in smokers in the lowest quartile when compared with other participants who smoked.
]Proposed mechanisms
The results of this study mirror those of the Rotterdam Study, which associated high serum lycopene status with a reduced risk of aortic atherosclerosis. As is the case with other antioxidant nutrients, lycopene may cut heart disease risk by inhibiting the oxidation of LDL cholesterol particles, reducing lipid peroxidation and slowing the progression of arterial damage. Additionally, in vitro studies have shown that lycopene effectively suppresses adhesion of monocytes to endothelial cells.
Diet as part of a healthy lifestyle
It is worth noting that the men in the highest lycopene quartile had markedly better health profiles than others in the study. On average, they had higher serum levels of vitamin E, folate, and beta-carotene. They were less likely to smoke, and had a lower average BMI and blood pressure when compared with those in the lowest quartile of serum lycopene level. All of these factors - in combination with favorable lycopene status - probably contributed to the better outcomes recorded in this study.
Advice to patients
The key point of this current analysis is that lower serum lycopene levels were associated with narrowing and thickening of the lining of the carotid artery, an early sign of atherosclerosis that would not likely be detected outside of a clinical setting.
The message is clearly one of prevention rather than cure. A diet that provides a variety of antioxidant-rich fruits and vegetables - including tomatoes - appears to help slow the progression of arterial changes that ultimately results in heart disease.
(Note: the bioavailability of lycopene is higher in cooked tomato products than in fresh tomatoes. So, good choices for readily available lycopene are products like spaghetti sauce, pizza, and other foods that include cooked tomato.)
Source
Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. T. Rissanen, S. Voutilainen, K. Nyyssönen, et al., Amer J Clin Nutr, 2003, vol. 77, pp. 133--138xxxxx
drveejay11
New member
Good stuff Geo 
J
Juice Authority
Guest
Great post Doc but damn that's a lot of supps to be taking.
bicepts101
New member
awsome
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