norr , I you F*in nuts or stupid. I hope just misinformed. No one here should be taking that shit (Sinemet 250mg levodopa and 25mg carbidopa). Do your homework before tossing shit like that around. Someone could get hurt. The last thing this board needs is some 17 or 18 kid getting their hands on that stuff because they read about it here. Do a search it has been disscued before. For anyone who may have been swayed by this post, do not take this stuff. Read below:
ADVERSE REACTIONS
Tablets
The most common serious adverse reactions occurring with carbidopa-levodopa are choreiform, dystonic, and other involuntary movements. Other serious adverse reactions are mental changes including paranoid ideation and psychotic episodes, depression with or without development of suicidal tendencies, and dementia. Convulsions also have occurred; however, a causal relationship with carbidopa-levodopa has not been established.
A common but less serious effect is nausea.
Less frequent adverse reactions are cardiac irregularities and/or palpitation, orthostatic hypotensive episodes, bradykinetic episodes (the "on-off" phenomenon), anorexia, vomiting, and dizziness.
Rarely, gastrointestinal bleeding, development of duodenal ulcer, hypertension, phlebitis, hemolytic and non-hemolytic anemia, thrombocytopenia, leukopenia, and agranulocytosis have occurred.
Laboratory tests which have been reported to be abnormal are alkaline phosphatase, SGOT (AST), SGPT (ALT), lactic dehydrogenase, bilirubin, blood urea nitrogen, protein-bound iodine, and Coombs test.
Other adverse reactions that have been reported with levodopa are:
Nervous System: ataxia, numbness, increased hand tremor, muscle twitching, muscle cramps, blepharospasm (which may be taken as an early sign of excess dosage, consideration of dosage reduction may be made at this time), trismus, activation of latent Horner's syndrome.
Psychiatric: confusion, sleepiness, insomnia, nightmares, hallucinations, delusions, agitation, anxiety, euphoria.
Gastrointestinal: dry mouth, bitter taste, sialorrhea, dysphagia, bruxism, hiccups, abdominal pain and distress, constipation, diarrhea, flatulence, burning sensation of tongue.
Metabolic: weight gain or loss, edema.
Integumentary: malignant melanoma (see also CONTRAINDICATIONS), flushing, increased sweating, dark sweat, skin rash, loss of hair.
Genitourinary: urinary retention, urinary incontinence, dark urine, priapism.
Special Senses: diplopia, blurred vision, dilated pupils, oculogyric crises.
Miscellaneous: weakness, faintness, fatigue, headache, hoarseness, malaise, hot flashes, sense of stimulation, bizarre breathing patterns, neuroleptic malignant syndrome.
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