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SteelWeaver
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If you've been taking your vitamin C directly post-workout, thinking its anti-oxidant properties will speed recovery, think again! Check this out ...
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?CMD=Display&DB=PubMed
Free Radic Biol Med 2001 Sep 15;31(6):745-53
Supplementation with vitamin C and N-acetyl-cysteine increases oxidative
stress in humans after an acute muscle injury induced by eccentric exercise.
Childs A, Jacobs C, Kaminski T, Halliwell B, Leeuwenburgh C.
Biochemistry of Aging Laboratory, Center for Exercice Science, College of Human Performance,
University of Florida, Gainesville, FL 32611, USA.
There has been no investigation to determine if the widely used over-the-counter, water-soluble
antioxidants vitamin C and N-acetyl-cysteine (NAC) could act as pro-oxidants in humans during
inflammatory conditions. We induced an acute-phase inflammatory response by an eccentric arm
muscle injury. The inflammation was characterized by edema, swelling, pain, and increases in plasma
inflammatory indicators, myeloperoxidase and interleukin-6. Immediately following the injury, subjects
consumed a placebo or vitamin C (12.5 mg/kg body weight) and NAC (10 mg/kg body weight) for 7
d. The resulting muscle injury caused increased levels of serum bleomycin-detectable iron and the
amount of iron was higher in the vitamin C and NAC group. The concentrations of lactate
dehydrogenase (LDH), creatine kinase (CK), and myoglobin were significantly elevated 2, 3, and 4 d
postinjury and returned to baseline levels by day 7. In addition, LDH and CK activities were elevated
to a greater extent in the vitamin C and NAC group. Levels of markers for oxidative stress (lipid
hydroperoxides and 8-iso prostaglandin F2alpha; 8-Iso-PGF2alpha) and antioxidant enzyme
activities were also elevated post-injury. The subjects receiving vitamin C and NAC had higher
levels of lipid hydroperoxides and 8-Iso-PGF2alpha 2 d after the exercise. This acute human
inflammatory model strongly suggests that vitamin C and NAC supplementation immediately
post-injury, transiently increases tissue damage and oxidative stress.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?CMD=Display&DB=PubMed
Free Radic Biol Med 2001 Sep 15;31(6):745-53
Supplementation with vitamin C and N-acetyl-cysteine increases oxidative
stress in humans after an acute muscle injury induced by eccentric exercise.
Childs A, Jacobs C, Kaminski T, Halliwell B, Leeuwenburgh C.
Biochemistry of Aging Laboratory, Center for Exercice Science, College of Human Performance,
University of Florida, Gainesville, FL 32611, USA.
There has been no investigation to determine if the widely used over-the-counter, water-soluble
antioxidants vitamin C and N-acetyl-cysteine (NAC) could act as pro-oxidants in humans during
inflammatory conditions. We induced an acute-phase inflammatory response by an eccentric arm
muscle injury. The inflammation was characterized by edema, swelling, pain, and increases in plasma
inflammatory indicators, myeloperoxidase and interleukin-6. Immediately following the injury, subjects
consumed a placebo or vitamin C (12.5 mg/kg body weight) and NAC (10 mg/kg body weight) for 7
d. The resulting muscle injury caused increased levels of serum bleomycin-detectable iron and the
amount of iron was higher in the vitamin C and NAC group. The concentrations of lactate
dehydrogenase (LDH), creatine kinase (CK), and myoglobin were significantly elevated 2, 3, and 4 d
postinjury and returned to baseline levels by day 7. In addition, LDH and CK activities were elevated
to a greater extent in the vitamin C and NAC group. Levels of markers for oxidative stress (lipid
hydroperoxides and 8-iso prostaglandin F2alpha; 8-Iso-PGF2alpha) and antioxidant enzyme
activities were also elevated post-injury. The subjects receiving vitamin C and NAC had higher
levels of lipid hydroperoxides and 8-Iso-PGF2alpha 2 d after the exercise. This acute human
inflammatory model strongly suggests that vitamin C and NAC supplementation immediately
post-injury, transiently increases tissue damage and oxidative stress.
