Not sure what you're looking for with this. I don't know of any pharm grade drugs, but I know nettle root does.
Schottner M, Gansser D, Spiteller G. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Medica. 1997;63(6):529-532.