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Do antiestrogens produce a rebound effect once stopped ?
- Thread starter gtrack
- Start date
macrophage69alpha
New member
rebound effect- not per se
however the removal of the estrogen antagonist (without dealing with the underlying estrogen problem) will result in at least partial resumption of the symptoms.
there may be some shifts in the hormone regulatory system, including possible increases of aromatase production (this has not been studied.. so there is no data one way or the other)
however the removal of the estrogen antagonist (without dealing with the underlying estrogen problem) will result in at least partial resumption of the symptoms.
there may be some shifts in the hormone regulatory system, including possible increases of aromatase production (this has not been studied.. so there is no data one way or the other)
N
NRF
Guest
Discontinuation of anti-aromatses such as anastrozole, causes the aromatase enzyme to up-regulate. There are studies showing this for almost all the anti-aromatase type ancilliaries. Exemestane is the only exception. Then what happens when your cycle ends is that your endo test which is:
Tesoterone produced - testosterone lost due to the peripheral conversion of your testosterone to estrogen via the aromatase enzyme.
Is going to be lower because the aromatase enzyme has up-regulated, therfore more endogeneously produced testosterone is converted to estrogen via the aromatase enzyme.
Novaldex on the other hand has no impact on the aromatase enzyme since it doesn't affect it. What tamoxifen does is simply attach itself to the ER's, not letting the far more powerful estrogen do the same. You have to remember that Tamoxifen is a weak estrogen. So what ends up happenning is that your estrogen levels remain unchanged, take into account that the tamoxifen is only not letting the estrogen bind to the ER's. However, since you're most likely on test or a compound that aromatizes into esrogen, you're going to have supraphysiological levels of estrogen floating around your blood stream, however they are unable to exert any effects because the ER's are already taken up by the tamoxifen.
In short:
W/ Novaldex: You have endo estrogen + estrogen produced by the aromatse enzyme by the AAS you're using(Lets use test as an example), floating around your bloodstream.
Upon cessation of the AAS, your body will take a few weeks to get back to estrogenic homeostasis.....that's the reason why Novaldex should ALWAYS be used post-cycle. This , in order to give the body the chance to reach estrogenic homeostasis(Your pre-cycle levels).
Tesoterone produced - testosterone lost due to the peripheral conversion of your testosterone to estrogen via the aromatase enzyme.
Is going to be lower because the aromatase enzyme has up-regulated, therfore more endogeneously produced testosterone is converted to estrogen via the aromatase enzyme.
Novaldex on the other hand has no impact on the aromatase enzyme since it doesn't affect it. What tamoxifen does is simply attach itself to the ER's, not letting the far more powerful estrogen do the same. You have to remember that Tamoxifen is a weak estrogen. So what ends up happenning is that your estrogen levels remain unchanged, take into account that the tamoxifen is only not letting the estrogen bind to the ER's. However, since you're most likely on test or a compound that aromatizes into esrogen, you're going to have supraphysiological levels of estrogen floating around your blood stream, however they are unable to exert any effects because the ER's are already taken up by the tamoxifen.
In short:
W/ Novaldex: You have endo estrogen + estrogen produced by the aromatse enzyme by the AAS you're using(Lets use test as an example), floating around your bloodstream.
Upon cessation of the AAS, your body will take a few weeks to get back to estrogenic homeostasis.....that's the reason why Novaldex should ALWAYS be used post-cycle. This , in order to give the body the chance to reach estrogenic homeostasis(Your pre-cycle levels).
macrophage69alpha
New member
NRF said:
this incorrect. Just because it does not interact directly with the aromatase enzyme does not mean that it does not impact the production of aromatase.
MASSIVE1000
New member
The body must always remain in homeostasis...in other words...If you are dehydrated, your body is going to suck up any amt. of sodium possible to bring the body back into check....another example is with testosterone...when you are juicing, the steroids block cortisol, what does your body then do? It produces even more cortisol...when you get off the steroids, all this cortisol floating around in your body then attacks the muscle cells...this is why bros come off and all of a sudden deflate...so in order for your body to maintain homeostasis, it is going to release more estrogen to bring the body back into sinc.
N
NRF
Guest
macrophage69alpha said:
If you don't mind could you show me a study on that. I've never seen that one. Obviously, when on test, your aromatase converts more test into estrogen (Thus you could say it's acting in an up-regulated manner), but I fail to see how novaldex impacts the aromatase, as it has no direct impact on the aromatase function. It simple attaches itself to the ER's. Allthough there are obviously supra-physiological levels of estrogen floating around then, it's not related to the tamoxifen directly, you might have a case for an indirect cause, but direct? I just don't see it.
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