Product Name 2,4-DINITROPHENOL
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Toxic (EU). Dangerous for the environment.
Explosive when dry. Toxic by inhalation, in contact with skin and if swallowed. Danger of cumulative effects. Irritating to eyes, respiratory system and skin. Very toxic to aquatic organisms. Target organ(s): Liver. Central nervous system. Readily absorbed through skin.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 3
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 3
REACTIVITY: 1
*additional chronic hazards present.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
EXPLOSION HAZARDS
May explode when heated.
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable solid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Light sensitive. Heat sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Light yellow
Form: Crystalline
Property Value At Temperature or Pressure
Molecular Weight 184.11 AMU
pH 2.6 - 4.4
BP/BP Range N/A
MP/MP Range 111 °C
Freezing Point N/A
Vapor Pressure < 0.001 mmHg 20 °C
Vapor Density 6.35 g/l
Saturated Vapor Conc. N/A
SG/Density 1.683 g/cm3 24 °C
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 1.67
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:2.5 mg/ml H2O
Other Solvents: ACETONE, CHLOROFORM
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Light sensitive. Heat sensitive.
Materials to Avoid: Strong oxidizing agents, Strong bases, Acid chlorides, Acid anhydrides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Liver. Central nervous system. Eyes. Kidneys. Blood. Lungs.
SIGNS AND SYMPTOMS OF EXPOSURE
Disrupts oxidative phosphorylation which results in increased
metabolism, consumption of oxygen and production of heat.
Exposure is characterized by sudden onset of fatigue, thirst,
and sweating. Symptoms include nausea, vomiting, anorexia,
weakness, dizziness, vertigo, headache, and sweating. Damage to the liver. Dermatitis. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
TOXICITY DATA
Oral
Human
36 mg/kg
LDLO
Remarks: Behavioral:Coma. Cardiac: Change in rate. Nutritional
and Gross Metabolic:Changes in:Body temperature increase.
Oral
Rat
30 mg/kg
LD50
Subcutaneous
Rat
25 MG/KG
LD50
Intravenous
Rat
72 MG/KG
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Lungs, Thorax, or Respiration:Respiratory stimulation.
Oral
Mouse
45 mg/kg
LD50
Remarks: Behavioral:Change in motor activity (specific assay).
Behavioral:Ataxia. Behavioral:Tetany.
Intraperitoneal
Mouse
26 MG/KG
LD50
Subcutaneous
Mouse
58 MG/KG
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Lungs, Thorax, or Respiration:Respiratory stimulation.
Intravenous
Mouse
56 MG/KG
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Lungs, Thorax, or Respiration:Respiratory stimulation.
Oral
Cat
75 mg/kg
LD50
Oral
Rabbit
30 mg/kg
LD50
Remarks: Behavioral:Change in motor activity (specific assay).
Behavioral:Ataxia. Behavioral:Tetany.
Oral
Guinea pig
81 mg/kg
LD50
Remarks: Behavioral:Change in motor activity (specific assay).
Behavioral:Ataxia. Behavioral:Tetany.
Intraperitoneal
Guinea pig
28 MG/KG
LD50
Intramuscular
Pigeon
6500 UG/KG
LD50
Remarks: Nutritional and Gross Metabolic:Changes in:Body
temperature increase.
Oral
Bird (wild)
13 mg/kg
LD50
IRRITATION DATA
Skin
Rabbit
300 mg
4W
I
Remarks: Mild irritation effect
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 40800 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (10-12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - MUTAGEN
Species: Rat
Dose: 100 UMOL/L
Cell Type: liver
Mutation test: DNA damage
Species: Mouse
Route: Intraperitoneal
Dose: 10 GM/KG
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 7 MMOL/L
Cell Type: lung
Mutation test: DNA inhibition
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 2040 MG/KG
Route of Application: Oral
Exposure Time: (8D PRE-21D POST)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Weaning or lactation index (e.g., # alive at weaning per # alive
at day 4).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 48 h
Value: 40 mg/l
Test Type: EC50 Algae
Species: SELENASTRUM
Time: 72 h
Value: 5.55 - 17.4 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 6.1 - 7 mg/l
Test Type: LC50 Fish
Species: Cyprinodon variegatus (Sheepshead minnow)
Time: 96 h
Value: 13 - 36.3 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 1.76 - 5.9 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.
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