The reason for this thread is b/c some guys go on month long DNP cycles thinking they are A-OK as far as muscle goes..
This is incorrect!!!
I'm not sure how (in the hell) this falacy got started but it is a HUGE mistake to believe that DNP is anti-catabolic.
In a muscle cell
What is true is that during periods low blood sugar (at rest) high levels of acytyl CoA (from breakdown of fatty acids) shut off glycolisis. Entry of glucose into muscle cells deminishes as insulin levels drop drastically. THe muscle cell shifts fuel usage from glucose to almost exclusively fatty acids.
In the liver
However, something different goes on in the liver. It's glycolosis deminishes as well however the liver's job is to produce fuel for the brain as a top priority. ONce all of it's stored glucose is exported to the blood for the brain, the liver begins transaminating amino acids from muscle protein to make glucose.(gluconeogenesis).
When someone is on DNP, this is an ongoing process since the liver cannot store any glycogen.
So DNP IS NOT anti-catabolic!
Lastly, AAS are NOT anti-catabolic on DNP. And we are lucky. IF AAS stopped muscle protein from being degraded, our brains would suffer!!! Furthermore, as I have said in the past, AAS don't work at all on someone on DNP. I know I said an absolute and nothing is absolute, but the value from AAS while on an effective DNP dose is so little it might as well be an absolute.
I just dont want guys to be on these low-dose month long cycles thinking the DNP is going to save muscle for them. No, DNP is not literally catabolic (meaning it does not go into cell by itself and break down proteins) but the energy defecint it puts the cell through causes a highly catabolic system.
Andy
This is incorrect!!!
I'm not sure how (in the hell) this falacy got started but it is a HUGE mistake to believe that DNP is anti-catabolic.
In a muscle cell
What is true is that during periods low blood sugar (at rest) high levels of acytyl CoA (from breakdown of fatty acids) shut off glycolisis. Entry of glucose into muscle cells deminishes as insulin levels drop drastically. THe muscle cell shifts fuel usage from glucose to almost exclusively fatty acids.
In the liver
However, something different goes on in the liver. It's glycolosis deminishes as well however the liver's job is to produce fuel for the brain as a top priority. ONce all of it's stored glucose is exported to the blood for the brain, the liver begins transaminating amino acids from muscle protein to make glucose.(gluconeogenesis).
When someone is on DNP, this is an ongoing process since the liver cannot store any glycogen.
So DNP IS NOT anti-catabolic!
Lastly, AAS are NOT anti-catabolic on DNP. And we are lucky. IF AAS stopped muscle protein from being degraded, our brains would suffer!!! Furthermore, as I have said in the past, AAS don't work at all on someone on DNP. I know I said an absolute and nothing is absolute, but the value from AAS while on an effective DNP dose is so little it might as well be an absolute.
I just dont want guys to be on these low-dose month long cycles thinking the DNP is going to save muscle for them. No, DNP is not literally catabolic (meaning it does not go into cell by itself and break down proteins) but the energy defecint it puts the cell through causes a highly catabolic system.
Andy

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