I been using the depot for about a month and it is the best GH I have used. To answer your question, I would think the depot would be the same on the problem of insulin sensitivity. But, it might also be better because it tappers itself. I used daily injects of around 4-6IU Ed for 16 months and I was not insulin sensitive. I ate pretty clean, avoid high carb foods ( for the most part) and i think you'll be fine. Unless you have family history of insulin problems.