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This is from an "instruction sheet" in a deca package:
Characteristics:
DECA_DURABOLIN is an injectable anabolic preparation. The pharmacologically active substance is nandrolone. The decanoate ester gives the preperation a duration of action of about three weeks after injection.
Nandrolone is chemically related to the male hormone. Compared to testosterone, it has an enhanced anabolic and reduced androgenic activity. This has been demonstrated in animal bioassys and explained by receptor binding studies.
The low androgenicity of nandrolone is confirmed in clinical use.
In the human, DD has been shown to posetively influence calcium metabolism and to increase bone massosteoporosis. In women with dissiminated mammary carcinoma, DD has been reported to produce objevtive regresssions for many months. Furthermore DD has a nitrogen-saving action. This effect on protein and metabolismhas been established by metabolic studies and is utilized therapeutically in conditions where a protein deficiency exists such as during chronic debliliating diseases and after major surgery and severe trauma, in these conditions DD serves as a supportive adjunc to specific therapies and dietary measures as well as parenteral nutrition.
Androgenic effects (e-g. vintisation) are relatively uncommon at the recommended dosages. Nadrolone lacks the C17 alpha-alkyl group wich is associated with the occurance of liver dysfunction and cholestasis.
Pharmacokinetics:
Nandrolone decanoate is slowly released from the injection site inte to the blood with a half-life of 6 days. In the blood , the ester is rapidly hydrolysed into nandrolone with a hlf-life of one or less. The half-life of the combined process of hydrolysis of nandrolone decanoate and of distribution and elimination of nandrolone is 3-4 hours. Nandrolone is metabolised by the liver. 19-Norandrosterone, 19-noreriocholanolone 19-norepiandrosterone have been idientified as metabolites in the urine. It is known wheter thes metabolites display a pharmacological action.
Indications:
Osteoprosis
For the pallitiative ttreatment of selected cases of disseminated mammary carcinoma in women.
As anadjunct to specific therapies and dietary measures in pathologic conditions characterized by a negative nitrogen balance.
N.B: for an optimal therapeutic effect it is necessary to administer adequate amounts of vitamins, minerals, and protein in a calorie-rich diet.
Contra-Indications:
- Pregnacy
- Known or suspect carcinoma of the prostate or breast in the male.
Warnings and precautions:
- If signs of virilisation develops, discontinuation of the treatment shoult be considered, preferably in consulation with the patient.
- It is recommended to monitor patients with any of the following conditions:
* Latentor or overt cardiac failure, renal dysfunction, hypertension or migraine (or history of these conditions), since anabolic steroids my occasionally induce fluid retention.
* Incomplete statural growth, since anabolic steroids in high dosages may accelerate epiphyseal closure.
* skeletal metastases of breast carcinoma. In these patients hypercalcaemia may developboth spontaneously and as a result of anabolic steroid therapy. The latter can be indicative of a positive tumour response to the hormonal treatment. Nevertheless, the hypercalcaemia should first be treated apprpriately and after restoration of normal calcium levels hormone therapy can be resumed.
* Liver dysfunction.
- The use of anabolic steroids to enhance athletic ability may carry severe risks to the user´s health and should be (but isn´t hehe) discouraged.
Interactions:
Anabolic steroids may improve glucose tolerance and decrease the need for insulin or other antidiabetic medicines in diabetics.
Adverse Reactions:
High dosages, prolonged treatment and/or too frequent administration may cause:
- Virilisation wich appears in sensitive women as hoarseness, acne, hirsutism and icriease af libido: in prepubertal boys an increased frequency of erections and phallic enlargment, and in girls as an increase of pubic hair and clitorial hypertrophy.
Hoarseness may be the first sympton of vocal change wich may end in a long-lasting, sometimes irreversible deepening of the voice.
- Amenorrhoea
- Inhibitionof spermatogenesis
- Premature epiphyseal closure
- Fluid retention
That´s it folks!
Characteristics:
DECA_DURABOLIN is an injectable anabolic preparation. The pharmacologically active substance is nandrolone. The decanoate ester gives the preperation a duration of action of about three weeks after injection.
Nandrolone is chemically related to the male hormone. Compared to testosterone, it has an enhanced anabolic and reduced androgenic activity. This has been demonstrated in animal bioassys and explained by receptor binding studies.
The low androgenicity of nandrolone is confirmed in clinical use.
In the human, DD has been shown to posetively influence calcium metabolism and to increase bone massosteoporosis. In women with dissiminated mammary carcinoma, DD has been reported to produce objevtive regresssions for many months. Furthermore DD has a nitrogen-saving action. This effect on protein and metabolismhas been established by metabolic studies and is utilized therapeutically in conditions where a protein deficiency exists such as during chronic debliliating diseases and after major surgery and severe trauma, in these conditions DD serves as a supportive adjunc to specific therapies and dietary measures as well as parenteral nutrition.
Androgenic effects (e-g. vintisation) are relatively uncommon at the recommended dosages. Nadrolone lacks the C17 alpha-alkyl group wich is associated with the occurance of liver dysfunction and cholestasis.
Pharmacokinetics:
Nandrolone decanoate is slowly released from the injection site inte to the blood with a half-life of 6 days. In the blood , the ester is rapidly hydrolysed into nandrolone with a hlf-life of one or less. The half-life of the combined process of hydrolysis of nandrolone decanoate and of distribution and elimination of nandrolone is 3-4 hours. Nandrolone is metabolised by the liver. 19-Norandrosterone, 19-noreriocholanolone 19-norepiandrosterone have been idientified as metabolites in the urine. It is known wheter thes metabolites display a pharmacological action.
Indications:
Osteoprosis
For the pallitiative ttreatment of selected cases of disseminated mammary carcinoma in women.
As anadjunct to specific therapies and dietary measures in pathologic conditions characterized by a negative nitrogen balance.
N.B: for an optimal therapeutic effect it is necessary to administer adequate amounts of vitamins, minerals, and protein in a calorie-rich diet.
Contra-Indications:
- Pregnacy
- Known or suspect carcinoma of the prostate or breast in the male.
Warnings and precautions:
- If signs of virilisation develops, discontinuation of the treatment shoult be considered, preferably in consulation with the patient.
- It is recommended to monitor patients with any of the following conditions:
* Latentor or overt cardiac failure, renal dysfunction, hypertension or migraine (or history of these conditions), since anabolic steroids my occasionally induce fluid retention.
* Incomplete statural growth, since anabolic steroids in high dosages may accelerate epiphyseal closure.
* skeletal metastases of breast carcinoma. In these patients hypercalcaemia may developboth spontaneously and as a result of anabolic steroid therapy. The latter can be indicative of a positive tumour response to the hormonal treatment. Nevertheless, the hypercalcaemia should first be treated apprpriately and after restoration of normal calcium levels hormone therapy can be resumed.
* Liver dysfunction.
- The use of anabolic steroids to enhance athletic ability may carry severe risks to the user´s health and should be (but isn´t hehe) discouraged.
Interactions:
Anabolic steroids may improve glucose tolerance and decrease the need for insulin or other antidiabetic medicines in diabetics.
Adverse Reactions:
High dosages, prolonged treatment and/or too frequent administration may cause:
- Virilisation wich appears in sensitive women as hoarseness, acne, hirsutism and icriease af libido: in prepubertal boys an increased frequency of erections and phallic enlargment, and in girls as an increase of pubic hair and clitorial hypertrophy.
Hoarseness may be the first sympton of vocal change wich may end in a long-lasting, sometimes irreversible deepening of the voice.
- Amenorrhoea
- Inhibitionof spermatogenesis
- Premature epiphyseal closure
- Fluid retention
That´s it folks!
