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Danatrol (danazol, ladogal...)
The active principle of both medicines is danatrol
DANATROL:
4-androsten-[2, 3-d]isoxazole-17alfa-etinil-17beta-ol
Danazol is a esteroid sexual hormone; its structure has similarities to the one of testosterone (4-androsten-3-ona, 17-beta-ol).
In position 17 alpha, has a replaced group, in this case a group etinil(HC @ Ch-ch 2 ).
At level of receivers:
Androgenic receivers -->> Enough marked
Progesterone recevivers -->> Slight
Estrogenic receivers -->> Low
This confers null androgenic effects, progestagenic (very slight) and estrogenic (almost null).
Enzimatically:
Inhibiting on:
- Enzymes that work splitting the lateral chain of colesterol (the sintesis of steroids hormones begin with this process generating pregnenolone).
- Enzymes implied in production of gonadic steroids.
Enzymatic inhibition is quite ample, affecting hidroxilases, demolases, dehydrogenases and isomerases.
This confers to it anti-androgenic effects (slight), anti-estrogenic(slight-moderated), anti-progesterone (moderated)
* The marked increase of the antiprogestagen effects comes by the inhibiting action from 3H-dexametasona. This inhibition peculiarly also produces winstrol and certain 17 alpha replaced structures (this is the reason why you will have read that winstrol has certain ability antiprogesterone).
Other mechanisms of action.
It affects the negative feedback, inhibiting secretion of hormones of the hipofisis (lh, fsh, cg) -->> these hormones control secretion of as important hormones as the testosterone; this alteration of the axis, plus to affect gonadotropic hormones, affects to other glucoproteinic hormones like the stimulant of thyroid (tsh). Also it reduces the SHBG (this effect is beneficial allowing free testosterone in plasma).
If you use nandrolone, oxymetholone or trembolone, it can be a good ally, or to use during a pair of weeks in the cycle, and to keep the progesterone levels and that simultaneously act another mechanism of estrogenic fight ; plus, in that brief space of time, if the cycle is not very androgenic, will produce an ascent of plasmatic testosterone.
If you are using testosterone, you will have more "free testosterone" available.
I do not think its use throughout the whole cycle is advisable and less if what you look for is to avoid possible problems related to the aromatysing, since on 5 enzyme alpha aromatase does not affect directly and its capacity anti-estrogenic is slight.
Its use like isolated medicine, without any pathology, is totally counter-productive, due to its slight antiandrogenic characteristic and the imbalance that produces in the hpt (hipothalamic - pituitary - testicular) axis (without the use of products like the clomifen, takes more than a month to restore the axis).
Something to consider:
If you use T3 or T4, then have in account that as it affects the thyroid hormone transporting globulins, it will produce a smaller availability and advantage of the exogen T3 and t4 that you are taking.
PharmaAtHome
The active principle of both medicines is danatrol
DANATROL:
4-androsten-[2, 3-d]isoxazole-17alfa-etinil-17beta-ol
Danazol is a esteroid sexual hormone; its structure has similarities to the one of testosterone (4-androsten-3-ona, 17-beta-ol).
In position 17 alpha, has a replaced group, in this case a group etinil(HC @ Ch-ch 2 ).
At level of receivers:
Androgenic receivers -->> Enough marked
Progesterone recevivers -->> Slight
Estrogenic receivers -->> Low
This confers null androgenic effects, progestagenic (very slight) and estrogenic (almost null).
Enzimatically:
Inhibiting on:
- Enzymes that work splitting the lateral chain of colesterol (the sintesis of steroids hormones begin with this process generating pregnenolone).
- Enzymes implied in production of gonadic steroids.
Enzymatic inhibition is quite ample, affecting hidroxilases, demolases, dehydrogenases and isomerases.
This confers to it anti-androgenic effects (slight), anti-estrogenic(slight-moderated), anti-progesterone (moderated)
* The marked increase of the antiprogestagen effects comes by the inhibiting action from 3H-dexametasona. This inhibition peculiarly also produces winstrol and certain 17 alpha replaced structures (this is the reason why you will have read that winstrol has certain ability antiprogesterone).
Other mechanisms of action.
It affects the negative feedback, inhibiting secretion of hormones of the hipofisis (lh, fsh, cg) -->> these hormones control secretion of as important hormones as the testosterone; this alteration of the axis, plus to affect gonadotropic hormones, affects to other glucoproteinic hormones like the stimulant of thyroid (tsh). Also it reduces the SHBG (this effect is beneficial allowing free testosterone in plasma).
If you use nandrolone, oxymetholone or trembolone, it can be a good ally, or to use during a pair of weeks in the cycle, and to keep the progesterone levels and that simultaneously act another mechanism of estrogenic fight ; plus, in that brief space of time, if the cycle is not very androgenic, will produce an ascent of plasmatic testosterone.
If you are using testosterone, you will have more "free testosterone" available.
I do not think its use throughout the whole cycle is advisable and less if what you look for is to avoid possible problems related to the aromatysing, since on 5 enzyme alpha aromatase does not affect directly and its capacity anti-estrogenic is slight.
Its use like isolated medicine, without any pathology, is totally counter-productive, due to its slight antiandrogenic characteristic and the imbalance that produces in the hpt (hipothalamic - pituitary - testicular) axis (without the use of products like the clomifen, takes more than a month to restore the axis).
Something to consider:
If you use T3 or T4, then have in account that as it affects the thyroid hormone transporting globulins, it will produce a smaller availability and advantage of the exogen T3 and t4 that you are taking.
PharmaAtHome
