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hormoneman
Banned
People make a big mistake when they read animal studies - they use the doses in the studies - let's say 5mg/kg per day - and simply multiply that by their bodyweight to get a human dose
WRONG - WRONG - WRONG
Here's a paper on converting animal doses to humans
Dose translation from animal to human studies revisited -- Reagan-Shaw et al. 22 (3): 659 -- The FASEB Journal
As the abstract states, "The animal dose should not be extrapolated to a human equivalent dose (HED) by a simple conversion based on body weight..." The FDA has stated that the extrapolation of animal dose to human dose is correctly performed only through normalization to body surface area. To convert mg/kg in rats to mg/kg in humans, you multiply by 0.162 (6/37). For mice to humans, multiply by 0.081 (3/37). There are several other values for other animals.
Please take this into account - especially with SARM S-4 - this could explain the vision problems
WRONG - WRONG - WRONG
Here's a paper on converting animal doses to humans
Dose translation from animal to human studies revisited -- Reagan-Shaw et al. 22 (3): 659 -- The FASEB Journal
As the abstract states, "The animal dose should not be extrapolated to a human equivalent dose (HED) by a simple conversion based on body weight..." The FDA has stated that the extrapolation of animal dose to human dose is correctly performed only through normalization to body surface area. To convert mg/kg in rats to mg/kg in humans, you multiply by 0.162 (6/37). For mice to humans, multiply by 0.081 (3/37). There are several other values for other animals.
Please take this into account - especially with SARM S-4 - this could explain the vision problems
