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Clomid & Nolvadex
- Thread starter TESTDEN
- Start date
swordfish151
New member
TESTDEN said:
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor in rats, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist -- the cofactor used in that tissue cannot bind and so the receptor remains inactive -- and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Also, Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.
Nolvadex (Tamoxifen Citrate) is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. The two molecules are also very similar in structure.
It is not correct that Nolvadex (Tamoxifen Citrate) reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
tiggerizme
Banned
They are borth aromatose inhibitors. Some AAS can aromatise to estrogen, which causes or can cause gyno. This answer your question?
H
Harj10
Guest
can you prevent gyno with clomid?
can you prevent gyno with nolva?
can you prevent gyno with nolva?
assapopolis
New member
Nolva is a SERM
