Clomid and IGF-1 output

[Smokescreen]

From taking steroids it seems that everybodies sex drive is great. But the load of semen is reduced during steroid use. Clomid does a great job of increasing your load. But what I've learned here on this great forum of ours is that clomid will lower IGF-1 output. This of course is something us BB's do not want. We want all the IGF-1 we can take. So 2 questions. What can be done to increase my load. And the second question is, since clomid will lower IGF-1 output should I be concerned about that since I take exogenous GH for my HRT?

 

[yomama]

From taking steroids it seems that everybodies sex drive is great. But the load of semen is reduced during steroid use. Clomid does a great job of increasing your load. But what I've learned here on this great forum of ours is that clomid will lower IGF-1 output. This of course is something us BB's do not want. We want all the IGF-1 we can take. So 2 questions. What can be done to increase my load. And the second question is, since clomid will lower IGF-1 output should I be concerned about that since I take exogenous GH for my HRT?

Clomid lowers IGF-1? Where'd you read that?

 

[Smokescreen]

IGF-1 output. Where did I read that? No where. Everybody on this forum told me so.

 

[poantrex]

Yes, it is true. At least among women. K plz

And to answer the question: I wouldn't be too concerned if you are taking
exo-GH. That should more than correct the deficiency.

Decline in insulin-like growth factor I levels after clomiphene citrate does not correct hyperandrogenemia in polycystic ovary syndrome.

Fiad TM, Smith TP, Cunningham SK, McKenna TJ.

Department of Investigative Endocrinology, University College, Dublin, Ireland.

It is widely accepted that the action of clomiphene citrate (CC) is mediated through its antiestrogenic properties on the hypothalamic-pituitary axis. Although insulin-like growth factor I (IGF-I) enhances the thecal cell response to LH, and estrogen treatment is associated with a reduction in IGF-I levels, CC is known to decrease circulatory IGF-I levels in polycystic ovary syndrome (PCOS) patients. The impact of lowering IGF-I levels on androgen levels in PCOS is unknown. This study was designed to examine the impact of CC treatment on the interrelationships of IGF-I, androgens, and estrogens in normal subjects and patients with PCOS. IGF-I, gonadotropin, androgen, estrogen, and sex hormone-binding globulin levels were measured in 8 PCOS patients and 10 normal subjects before and after treatment with the antiestrogen CC. Studies were performed in the early follicular phase, days 4-6 of the menstrual cycle in normal subjects. In normal subjects, CC treatment led to a significant increase in estradiol (84 +/- 10 to 234 +/- 62 pmol/L, untreated and CC treated; P < 0.05) and estrone (125 +/- 14 to 257 +/- 29 pmol/L; P < 0.05) levels with a significant lowering of IGF-I levels (297 +/- 25 to 230 +/- 17 micrograms/L; P < 0.05). Similarly, in PCOS patients a significant increase in estradiol (110 +/- 11 to 245 +/- 58 pmol/L; P < 0.05) and estrone (301 +/- 32 to 401 +/- 90 pmol/L; P < 0.05) levels and a significant lowering of IGF-I levels (330 +/- 43 to 214 +/- 27 micrograms/L; P < 0.05) were observed after CC treatment. However, no significant correlation was observed between changes in IGF-I and changes in estradiol in either group. Compared to pretreatment levels, no significant changes in the following parameters were observed after 5 days of CC treatment in either study group: testosterone, testosterone/sex hormone-binding globulin ratio, and androstenedione. The relationship among CC treatment, gonadotropin, estrogen, and IGF-I levels is complex. Changes in blood IGF-I levels are not associated with changes in androgen levels, although paracrine and or autocrine effects cannot be excluded.

PMID: 9661617 [PubMed - indexed for MEDLINE]

 

[Smokescreen]

TOO MUCH READING TO DO!!! I can't do it! I'm lazy. Plus it looks like this article is towards women. Were men...we need articles and info based on men.

 

[poantrex]

TOO MUCH READING TO DO!!! I can't do it! I'm lazy. Plus it looks like this article is towards women. Were men...we need articles and info based on men.

Short version: yes it lowers IGF-1. There is no reason to believe that clomid acts differently in men than women in this respect, since it raises the same hormones in both sexes.

 

[yomama]

Short version: yes it lowers IGF-1. There is no reason to believe that clomid acts differently in men than women in this respect, since it raises the same hormones in both sexes.

I dont know about that. It's kinda like alcohol, it raises test in women but lowers it in men. You see? So, maybe clomid doesnt work the same. I have no clue.

 

[Smokescreen]

If it lowers IGF-1...fine! But I need to know if I should even be concerned about this since I take exogenous GH for my HRT?