Clen and Cholesterol

[weaselboy]

Hi
I am still small and Fat (18% BF). Have been experimenting with Clenbuterol.
My Clenbuterol is Russian NIHFI 20 Mcg Tablets. I believe they are genuine.

First Cycle:
20 . 40 . 60 . 80 .120 stay at 120 for 1 week.

Results : Inconclusive

Second Cycle : 20 . 60 . 100 . Stay at 100 for 1 week Add 2X50 mg Benadryl
after day 3

Results : Inconclusive . Benadryl makes me sleepy

Third Cycle : 20 Mcg at night every day for 2 weeks plus 1 x 50 mg Ben
1000 mg Taurine per day

Results : Slightly better

Blood tests before and after first and third cycle

Liver Values : No significant change
T3 , T4 and TSH : T4 slightly elevated ( Above normal )

Blood pressure whilst on cycle : No significant change In Systolic or Disystolic
pressure regardless of dose.
Significant Tachycardia : From normal resting rate in high 60's low 70's to
resting rate of 95-105

Wierd Results : LDL : Slight 9 mg/dl increase
HDL : Very strange 25 mg/dl increase from 48 to 73

No apreciable increase of body tempertaure on Clenbuterol regardless of dose.

We can not explain the HDL increase and in fact can't actualy determine if
its from the Clenbuterol or not.

conclusions : Newbies with high body fat like me should stay away from Clen
as it apears to be no more effective than diet and exercise.


Aditional conclusions : The temor nervousness ect asosiated with Clenbuterol
can be treated efectivly with Xanax ( Alprazolam ) But then you need to
deal with the side effects of stopping Alprazolam ( Tremors , nervousness )


The doctor I discuss this with is a gynocologist, not en endocrinologist
So alltough its probably medicaly sound , it may lead to me having a very
healthy Vagina , even though Im not a woman

Please forgive my awfull spelling . Ive been living in Spain since I was 11
so I spell like an elevenyearold wots been speaking and writing Spanish for
17 years. Im sorry.

Can anybody explain or relate the 50% Increase of HDL to Clenbuterol use ?

I am going to just diet and exercise for 3 months and then try either a
Clenbuterol/t3 Cycle with a very low dose of t3 (10 Mcg day) or a Low dose
dnp - dinitrophenol - cycle. Both The doctor & I are very impressed with the medical knoweldge
and depth of study on this site. In Spain oral winstrol can be optained with
a prescription , so will may mess about with that next after that.

the weight training during the cycles was reasonable , but the diet was
patheticly low in calories ( 1500 or less per day ) eaten once a day. We
know its stupid but It seems to be the only way I can effectivly loose body
fat . ( I have lost 14% )

 

[todoveritas]

Lipid profiles, including cholesterol and HDL have long been known to be affected by stimulation of adrenergic receptors by catecholamines such as norepinephrine. Clenbuterol is a beta-2 adrenergic agonist and there are a few studies which support that this physiologic effect occurs with this compound as well.
1: Indian J Exp Biol. 2003 Dec;41(12):1452-5;
2.: Can J Physiol Pharmacol. 1992 Dec;70(12):1555-62

Related studies of propranolol and other beta blockers on plasma lipid concentrations have revealed a possible mechanism of action. It is proposed that unopposed alpha stimulation inhibits lipoprotein lipase with a subsequent rise in plasma triglyceride and fall in HDL and cholesterol concentrations. Thus, theoretically, catecholamine-mediated changes are responsible for the affect on lipid profiles. Exactly how this occurs, however, is not yet known.

Subsequent studies have shown clenbuterol also causes norepinephrine release, although this effect is thought to occur through a central mechanism, occuring specifically in the hypothalamus.
1: Res Commun Mol Pathol Pharmacol. 1995 Nov;90(2):179-90

So although studies have revealed that the lipid changes are mediated through a catecholamine affect in the hypothalamus, we still don't exactly know what occurs after that. Certainly it could be tied into the complicated biofeedback mechanism affecting any number of the NE-mediated physiological functions associated with the hypothalamus and hippocampus and could be a central receptor activation, rather than peripheral. For example, because the NE release does occur in the CNS, it may in fact invoke alpha receptor sites (in addition to the peripheral beta pulmonary sites). This would have the effect of inhibition of lipoprotein lipase similar to that seen in the beta-blocker studies.

Sorry, but this qualified "we think this is going on" is about the best I can do!

 

[weaselboy]

.

Sorry, but this qualified "we think this is going on" is about the best I can do![/QUOTE]

I wish I could understand it ! But Thanks . I'll read up until I do.

 

[todoveritas]

In layman's terms, clenbuterol causes the release of a neurotransmitter. a catecholamine called norepinephrine. Norepinephrine stimulates adrenergic receptors - Alpha-receptors in the Central Nervous System (the brain) and Beta-receptors in the body (specifically the lungs). It is thought the alpha stimulation inhibits lipoprotein lipase.
That's about as simple as I can put it. This stuff is pretty advanced for this forum and takes more than a working knowledge of Neurophysiology. You can PM me and I will try to find you some basic science resources. I know its hard if English is your second language.
Lo siento pero creo que probalamente su Ingles es mejor de mi Espanol.

 

[flotown]

In layman's terms, clenbuterol causes the release of a neurotransmitter. a catecholamine called norepinephrine. Norepinephrine stimulates adrenergic receptors - Alpha-receptors in the Central Nervous System (the brain) and Beta-receptors in the body (specifically the lungs). It is thought the alpha stimulation inhibits lipoprotein lipase.
That's about as simple as I can put it. This stuff is pretty advanced for this forum and takes more than a working knowledge of Neurophysiology. You can PM me and I will try to find you some basic science resources. I know its hard if English is your second language.
Lo siento pero creo que probalamente su Ingles es mejor de mi Espanol.

So are you among those who believe clen can stimulate muscle growth? I've always found this hard to believe because its effects seem to contradict this. Are you saying it may have this affect indirectly?

 

[weaselboy]

Su Español es muy bueno y sus conocimientos de bioquimica son verdaderamente impresionantes ! Me siento Humillado

 

[todoveritas]

IMO, a qualified yes. Most experienced BBs will tell you clen works better in a depleted state-that's where its use as an anti-catabolic comes in. However, studies show that it may have direct anabolic properties as well. How is a subject of much debate. The latest studies show, in layman's terms, that the adrenergic system stimulates muscle growth by redirecting nutrients from adipose tissue to muscle. Animal studies have shown that in nutrient-deprived states, catecholamine release increases myosatellite proliferation and muscle fiber hypertrophy. This effect was seen in addition to the effects on lipoprotein lipase described above.

 

[flotown]

IMO, a qualified yes. Most experienced BBs will tell you Clenbuterol works better in a depleted state-that's where its use as an anti-catabolic comes in. However, studies show that it may have direct anabolic properties as well. How is a subject of much debate. The latest studies show, in layman's terms, that the adrenergic system stimulates muscle growth by redirecting nutrients from adipose tissue to muscle. Animal studies have shown that in nutrient-deprived states, catecholamine release increases myosatellite proliferation and muscle fiber hypertrophy. This effect was seen in addition to the effects on lipoprotein lipase described above.

This is good info. I've had friends who have taken it before without aas and shown moderate muscle growth. Not compareable to aas but does seem to have helped. Do have links to these new studies. I'd like to read up on it.