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A good one on CLA & chromium picolinate improving glucose metabolism
Nutrition 21 Identifies Isomer of Cla That Significantly Improves Glucose Metabolism Without Insulin
Business Wire
February 07, 2002
PURCHASE, N.Y., Feb 7, 2002 (BUSINESS WIRE) -- Research Results Also Reveal That the Activity of the Isomer is Enhanced by Chromium Picolinate
Nutrition 21, Inc. (Nasdaq: NXXI) today announced the results of research that identified an isomer of conjugated linoleic acid (CLA) that resulted in a significant increase in glucose metabolism in muscle cells without the addition of insulin. The research further demonstrated that a combination of chromium picolinate and the newly identified active isomer of CLA resulted in an enhanced effect on glucose metabolism in muscle cells.
The increases in glucose metabolism noted with both the active isomer and the combination of the active isomer and chromium picolinate were achieved in the absence of added insulin, and in each instance the level of glucose metabolism was greater than the level produced when insulin was added.
Nutrition 21 has filed a patent application based on these research results, with plans to file additional patent applications in the future.
Gail Montgomery, president and chief executive officer of Nutrition 21, said, "The results of this early research, if confirmed in future studies, could have significant implications for the pharmaceutical treatment of both type 1 and type 2 diabetes, a $9 billion market in 2000. We intend to proceed as soon as possible with animal studies aimed at validating these initial findings."
The results of the various in vitro studies showed that not only is there an active CLA isomer, but that the presence of other CLA isomers inhibit the effect. The synergistic effect of chromium picolinate is such that both a composition containing chromium picolinate and CLA as well as chromium picolinate and the active isomer demonstrated significant increases in blood glucose uptake in muscle cells without the addition of insulin. In fact, the glucose uptake measured using the chromium picolinate and CLA isomer combination exceeded the results seen with insulin alone.
Nutrition 21 reported in June 2001 that it had filed for patent protection on the discovery that CLA alone was not efficacious in stimulating glucose metabolism in muscle cells, but when combined with chromium picolinate, caused a significant increase in glucose uptake.
Nutrition 21 Identifies Isomer of Cla That Significantly Improves Glucose Metabolism Without Insulin
Business Wire
February 07, 2002
PURCHASE, N.Y., Feb 7, 2002 (BUSINESS WIRE) -- Research Results Also Reveal That the Activity of the Isomer is Enhanced by Chromium Picolinate
Nutrition 21, Inc. (Nasdaq: NXXI) today announced the results of research that identified an isomer of conjugated linoleic acid (CLA) that resulted in a significant increase in glucose metabolism in muscle cells without the addition of insulin. The research further demonstrated that a combination of chromium picolinate and the newly identified active isomer of CLA resulted in an enhanced effect on glucose metabolism in muscle cells.
The increases in glucose metabolism noted with both the active isomer and the combination of the active isomer and chromium picolinate were achieved in the absence of added insulin, and in each instance the level of glucose metabolism was greater than the level produced when insulin was added.
Nutrition 21 has filed a patent application based on these research results, with plans to file additional patent applications in the future.
Gail Montgomery, president and chief executive officer of Nutrition 21, said, "The results of this early research, if confirmed in future studies, could have significant implications for the pharmaceutical treatment of both type 1 and type 2 diabetes, a $9 billion market in 2000. We intend to proceed as soon as possible with animal studies aimed at validating these initial findings."
The results of the various in vitro studies showed that not only is there an active CLA isomer, but that the presence of other CLA isomers inhibit the effect. The synergistic effect of chromium picolinate is such that both a composition containing chromium picolinate and CLA as well as chromium picolinate and the active isomer demonstrated significant increases in blood glucose uptake in muscle cells without the addition of insulin. In fact, the glucose uptake measured using the chromium picolinate and CLA isomer combination exceeded the results seen with insulin alone.
Nutrition 21 reported in June 2001 that it had filed for patent protection on the discovery that CLA alone was not efficacious in stimulating glucose metabolism in muscle cells, but when combined with chromium picolinate, caused a significant increase in glucose uptake.
