Can this happen with GH??

[Smokescreen]

Ok, if you use Testosterone then you'll be suppressed after usage....right? Therefore HCG, Clomid come into play to bring this hormone back to normal. Same goes for Thyroid Medication. Use it and you'll thyroid will be suppressed for a while. Same goes for Insulin. Use it and you might become a diabetic. Now what about for GH???? If I were to use GH and then stopped taking it...will I be low on Growth Hormone? Will my body stop producing natural GH????

 

[Sigmund Roid]

Yes, there MIGHT be a chance, even a permanent GH shutdown. Read the article below (although the bodybuilder used not only GH)

Neurol Res. 2001 Jun;23(4):336-8. Related Articles, Links


Secondary partial empty sella syndrome in an elite bodybuilder.

Dickerman RD, Jaikumar S.

National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Surgical Neurology Branch, Bethesda, MD, USA. [email protected]

The pituitary gland is a hormone-responsive gland and is known to vary in size depending on the hormonal status of the patient and the multifaceted positive and negative feedback hypothalamic-pituitary-gonadal axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrinopathies such as growth hormone deficiency, primary hypothyroidism, central diabetes insipidus and hypogonadism. Partial empty sella has also been shown to occur in patients with elevations in intracranial pressure. Secondary partial empty sella syndrome with significant pituitary gland atrophy from negative feedback inhibition of long-term exogenous hormonal use has not been previously reported. We are reporting on a case of partial empty sella syndrome occurring in an elite bodybuilder with a long history of exogenous abuse of growth hormone, testosterone and thyroid hormone. The pathophysiological mechanisms of secondary partial empty sella syndrome from exogenous hormone use and the possibility for elevations in intracranial pressure contributing to this syndrome will be discussed.

PMID: 11428511 [PubMed - indexed for MEDLINE]

 

[twistedneck]

Clipped from:

Forms of Human Growth Hormone (HGH)
By David Leonardi, M. D.

"Besides the low dose-high frequency technique, the physicians at
Cenegenics® also employ morning injections as opposed to evening. The reason
for this has to do with the biofeedback mechanism for growth hormone. Most
of our natural pituitary growth hormone secretion occurs at night during
deep stages of sleep. Injecting growth hormone at night raises the serum
level of growth hormone precisely during the time the pituitary is scheduled
to become active. This high serum level of growth hormone from the injection
can suppress our natural pituitary function by negative feedback. We then
not only lose the benefit of our own endogenous growth hormone, but also run
the risk of surpressing the pituitary, thus making it "lazy". For the most
part, the pituitary has completed its function and is at rest by 5 a.m.
Therefore injecting after awakening in the morning results in injecting "on
top of the peak" of endogenous (our own) growth hormone, so as not to
suppress the pituitary. By the time the pituitary is ready again for its
nighttime activity, the growth hormone given in the morning injection has
been completely metabolized. This eliminates the risk of pituitary
suppression.

And from Nandi

I'm not SWALE but the fallacy of that argument is that GH is not what is responsible for the negative feedback suppression of its own secretion, but rather IGF-1 produced primarily in the liver under the action of GH. IGF-1 levels peak at between 12 and 24 hours after administration of GH, depending on the dose. This is long after any GH has cleared your system. To think that you can use exogenous GH without any or minimal suppression of your own GH is wishful thinking.

The attached graph borrowed from

http://ajpendo.physiology.org/cgi/c...ull/276/6/E1009

shows how IGF-1 levels build up in your system after daily GH injections in a dose dependent manner. This will result in suppression of endogenous GH production no matter what time of day you inject.

Dose-related effect of 4-day treatment with recombinant human growth hormone (rhGH) on insulin-like growth factor I (IGF-I) and insulin-like growth factor-binding protein (IGFBP)-3 levels in 21 normal young subjects (* P < 0.001 vs. baseline). Arrows denote times of rhGH administration.

 

[Smokescreen]

I have my wife on this stuff. She's been taking 3 iu's of GH everyday in the morning for the past 8 weeks. I DO NOT! Want her to be suppressed when she comes off the stuff. Do you guys suggest that she come off the stuff now to avoid any problems???