Can someone explain what this means...

[warrio2345]

Been ressearching Formastane and came across this info on some "real clinical reasearch" that was done on it.

4-Hydroxyandrostenedione has also been given orally. Even though there is a marked first-pass effect with conversion in the liver to a glucuronidated derivative, oral doses of 250 mg reduce plasma estradiol by 53% and doses up to 1,000 mg produce no further suppression. The response rate after 3 months of therapy was 33%, and the only serious side effect from the oral dosage was leukopenia in a single patient.38

Formastane is supposed to reduce E2 fairly quickly after you administer it, within a few days and top out at about 50% E2 reduction. My question is whats in bold about the 33% after 3 months.

Does than mean after 3 months usage, instead of blocking 50% E2 it will only be blocking 33% so after about 4 months use ur body wont respond to it very much so you would need to switch to another AI, is that what that means??

 

[Zyglamail]

Got a link to the full study? Kinda hard to tell by just you comment.

 

[d_rson]

Dude, start one thread, state your issue you are doing all this research for, and post in THAT thread!

 

[warrio2345]

d-royson sometimes I like to do rersearch just to do research and sometimes all the info cant get gathered so i ask opinions... sometimes I just want to know whats out, knowing all the aspects of something does have its advantages even if im not putting a particualr compound in my body...so let it go man, this is a site to ask questions AFTER you have done the research, I have done the research and am now trying to get clarity on some things


Here is the website...not much more info on it. Bascally my understanding is that after 3 months it loses a good amount of its effectiveness, but just wanted to make sure i was reading it correctly

Classification -- Holland-Frei Cancer Medicine -- NCBI Bookshelf

 

[warrio2345]

I also found this in the study, although it loses its effectiveness somewhat it looks like o does not completely lose it for at least 6 months...

Plasma estradiol levels fell from baseline values of 10 to 11 pg/mL to levels of approximately 4 pg/mL for up to 7 months of therapy.

 

[warrio2345]

I also got this from another research site,
Formestane (4-hydroxyandrostenedione) is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and 30% during treatment with intramuscular formestone 250 or 500mg once every 2 weeks, and a further 20 to 30% of patients experience disease stabilisation. The median duration of response is between 8 and 14 months.

If I understand correctly wouldnt that mean that ppl are responding to form for between 8-14months give or take?? IS that what that means? Just want to know if I can use form on longer 16-20 week cycles???

 

[d_rson]

I understand, however, my point is that you start thread after thread, every single one about AI's or anti-estrogens, instead of starting one thread and continously posting followups and questions in that thread. If anyone reviews your post history, they will see exactly what I am talking about. I don't think I've ever seen you post anything about your cycles, just about AI's with many abandoned threads with unanswered questions.

Are you having an issue with the performance of AI's. Have you tried aromasin and it did not work for you? Have you tried adex? Letro? Forma? Until YOU try the products, there's no way to tell how YOU will react to them physiologically, since everyone is different.

Are you having a problem with Gyno? Do you have Gyno now, and are affraid of it getting worse? Or are you just paranoid about getting it?

What is your cycle history?

 

[Zyglamail]

.not much more info on it. Bascally my understanding is that after 3 months it loses a good amount of its effectiveness, but just wanted to make sure i was reading it correctly

I dont think your reading it correctly at all.

It looks to me like you are confusing the effect the drug has on estradiol with the effect it has on tumors.

Above the section you quoted it states.....

Patients initially received 500 mg intramuscularly every 2 weeks for 6 weeks and then 250 mg every 2 weeks thereafter. Plasma estradiol levels fell from baseline values of 10 to 11 pg/mL to levels of approximately 4 pg/mL for up to 7 months of therapy.

Which indicates the estradiol levels remained suppressed for up to 7 months.

Then for a phase 1 study it shows this.....

concentrations of drug during chronic therapy and 1 week after the last injection ranged from 0.7 to 23.2 ng/mL (mean 7.8 ng/mL). This might reflect a depot effect of the injected drug. During therapy, plasma estradiol levels fell from 7.2 ± 0.8 (standard error of mean [SEM]) pg/mL to 2.6 ± 2.8 pg/mL from 1 to 41 months after initiating treatment.

You have to keep in mind these tests where done to see how these drugs affected tumors. The idea is that tumors grow in the presence of estradiol so using an inhibitor would affect tumor growth so a lot of the numbers they are talking about are about the tumors response to the inhibitor.