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fitnesskid
New member
Here is the article I found the had some good/interesting info on bromo...what do you guys think? And how about a little karma for tracking this one down? I'd be psyched if bromo raised GH in a normal person (ie-person without a pituitary disorder)...I hope this serves to clear up a lot of the misinformation floating around here about bromo and its affects on GH/Prolactin....Thanks....
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Ergot-derived smart drugs (the benefits of rye fungi)
by Robert Mason Ph.D.
Bromocriptine- the most potent ergot
This semi-synthetic derivative of the ergo group of ergot alkaloids is a dopamine receptor agonist (for those who like precise detail it is a potent D2 agonist but also displays partial action on D1 receptors) and a prolactin inhibitor.
Its first major anti-aging use is the enhancement of dopamine, (a key brain neurotransmitter that undergoes an age-related decline). Past the age of 40 it is estimated that “on-average” the healthy person undergoes a dopamine decline of approximately 13% per decade (Ward, Fowkes & Morgenthaler). Accordingly, some neurologists have stated that “if we all live long enough we shall all become senile.” This is due to the fact that abnormally low levels of dopamine (70% to 80% loss) are then diagnosed as Parkinson’s disease, hence protection and enhancement of the dopamine producing neurons is a key strategy for anti-aging medicine. Not surprisingly then, bromocriptine is used in conjunction with other drugs (such as deprenyl and L-dopa) in the management of Parkinson’s disease, but anti-aging medicine considers its preventative properties too.
Its second major anti-aging use is the inhibition of prolactin, this hormone is one of the few that actually appears to increase with age. Prolactin is produced by the pituitary gland and its release is inhibited by bromocriptine.
Prolactin has been described as a “fat synthesis hormone” because one of its primary functions is to trigger lactation (milk production) and weight gain in pregnancy. In women, bromocriptine has been used to help restore ovulation (the process by which this action occurs is too complex to explain for this small article) but it also helps to reduce serum prolactin levels in men (although the precise role of prolactin in men is unclear).
A further possible need to control age-related prolactin levels is offered by some researchers who believe that prolactin is an immune system suppressant.
Bromocriptine also affects the most famous of all pituitary hormones- growth hormone (GH). Bromocriptine increases growth hormone secretion in individuals with normal growth hormone concentrations, but paradoxically suppresses GH secretion in some patients with acromegaly (a condition of excessive-production of GH). Studies indicate that bromocriptine does not affect the release of any other anterior pituitary hormones.
Due to its dopamine enhancement bromocriptine has even been cited as an aphrodisiac, although little effort has been made to study and confirm this action. There have been several reports of “better controlled” orgasms and “almost orgasms” before the real orgasm occurs. If any countries allow for more medical categories such as “weak orgasm syndrome” or perhaps “clinical sex-drive loss” then dopamine agonists such as bromocriptine are going to receive a lot of attention from the pharmaceutical manufacturers, especially in the wake of Viagra sales.
Another interesting clinical study administered a component of tobacco called DMBA to rats at a level where it is known to be very effective in producing breast cancer. However, rats that had been pretreated with bromocriptine completely avoided any cancer development. Bromocriptine therefore appears to also offer itself as a very potent free radical quencher.
One of the most recent studies indicates that bromocriptine may be a candidate for the treatment of Type-2 diabetes. This is because bromocriptine has been shown to suppress lipogenesis and improve glucose tolerance and insulin resistance.
One animal study suggested that a further action of bromocriptine is to alter CNS (central nervous system) regulating metabolism and as such has another important use in helping to prevent weight gain (this would be in addition to its improvement of diabetic conditions).
---------------------------------------------------------------
---------------------------------------------------------------
Ergot-derived smart drugs (the benefits of rye fungi)
by Robert Mason Ph.D.
Bromocriptine- the most potent ergot
This semi-synthetic derivative of the ergo group of ergot alkaloids is a dopamine receptor agonist (for those who like precise detail it is a potent D2 agonist but also displays partial action on D1 receptors) and a prolactin inhibitor.
Its first major anti-aging use is the enhancement of dopamine, (a key brain neurotransmitter that undergoes an age-related decline). Past the age of 40 it is estimated that “on-average” the healthy person undergoes a dopamine decline of approximately 13% per decade (Ward, Fowkes & Morgenthaler). Accordingly, some neurologists have stated that “if we all live long enough we shall all become senile.” This is due to the fact that abnormally low levels of dopamine (70% to 80% loss) are then diagnosed as Parkinson’s disease, hence protection and enhancement of the dopamine producing neurons is a key strategy for anti-aging medicine. Not surprisingly then, bromocriptine is used in conjunction with other drugs (such as deprenyl and L-dopa) in the management of Parkinson’s disease, but anti-aging medicine considers its preventative properties too.
Its second major anti-aging use is the inhibition of prolactin, this hormone is one of the few that actually appears to increase with age. Prolactin is produced by the pituitary gland and its release is inhibited by bromocriptine.
Prolactin has been described as a “fat synthesis hormone” because one of its primary functions is to trigger lactation (milk production) and weight gain in pregnancy. In women, bromocriptine has been used to help restore ovulation (the process by which this action occurs is too complex to explain for this small article) but it also helps to reduce serum prolactin levels in men (although the precise role of prolactin in men is unclear).
A further possible need to control age-related prolactin levels is offered by some researchers who believe that prolactin is an immune system suppressant.
Bromocriptine also affects the most famous of all pituitary hormones- growth hormone (GH). Bromocriptine increases growth hormone secretion in individuals with normal growth hormone concentrations, but paradoxically suppresses GH secretion in some patients with acromegaly (a condition of excessive-production of GH). Studies indicate that bromocriptine does not affect the release of any other anterior pituitary hormones.
Due to its dopamine enhancement bromocriptine has even been cited as an aphrodisiac, although little effort has been made to study and confirm this action. There have been several reports of “better controlled” orgasms and “almost orgasms” before the real orgasm occurs. If any countries allow for more medical categories such as “weak orgasm syndrome” or perhaps “clinical sex-drive loss” then dopamine agonists such as bromocriptine are going to receive a lot of attention from the pharmaceutical manufacturers, especially in the wake of Viagra sales.
Another interesting clinical study administered a component of tobacco called DMBA to rats at a level where it is known to be very effective in producing breast cancer. However, rats that had been pretreated with bromocriptine completely avoided any cancer development. Bromocriptine therefore appears to also offer itself as a very potent free radical quencher.
One of the most recent studies indicates that bromocriptine may be a candidate for the treatment of Type-2 diabetes. This is because bromocriptine has been shown to suppress lipogenesis and improve glucose tolerance and insulin resistance.
One animal study suggested that a further action of bromocriptine is to alter CNS (central nervous system) regulating metabolism and as such has another important use in helping to prevent weight gain (this would be in addition to its improvement of diabetic conditions).
