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Blood work after DNP
- Thread starter x_muscle
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DJdisfunkshun
New member
I have done many DNP cycles never had a blood test after . But DNP is very hard on the liver The longest cycle i have taken was 10 days but drank 3-4 gallons of water a day took milk thysle pills a butt load of vitsimans ( they help rebuild the liver emyzms ) taken at the tail of End of a ASS cycle. if you take a blood test please post and let me know the out come . would like to know
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Maetenloch
New member
I had blood tests after running 2 weeks of 200mg/day DNP and 12.5mcg of T3. All my values were within normal ranges - TSH was at the low end of normal which was to be expected since I was taking T3.
I've never seen any studies showing DNP is hard on the liver - evidence please...
I've never seen any studies showing DNP is hard on the liver - evidence please...
macrophage69alpha
New member
DJdisfunkshun said:
are you sure that you dont want to restate that... consistent intake over 3 gallons per day in most individuals, (those not over 250lbs) would likely lead to electrolyte depletion, hypotonia and possibly death.
DJdisfunkshun
New member
OK LOL when i was taking DNP i took at my peek 600MG a day my body mass was 295 @ 8% bf running 101 temp so at that temp i dropped lots or water sweating and trying to keep water voulem in my muscle to keep a good pump while working out on DNP seconde with the body burning carbs like crazy ATP that lines the muscle is depleted very fast on DNP thus making a 45 min work out seem like 2 hours so the added water voulem helps in many ways with keeping the electrolytes in the body high with added potossem supps
so depending on your body mass YES YOU ARE right but when on DNP the water goes fast through the body other wise when ON AAS one once of water per day per body pound thats what i did and it worked great.
so i am sorry for posting 6 gallons i looked back in my training log and it was 4 max sorry
so depending on your body mass YES YOU ARE right but when on DNP the water goes fast through the body other wise when ON AAS one once of water per day per body pound thats what i did and it worked great.
so i am sorry for posting 6 gallons i looked back in my training log and it was 4 max sorry
M
Mr.X
Guest
DJdisfunkshun said:
I highly doubt you're taking in 4 gallons of water per day, DNP or not.
DJdisfunkshun
New member
ok what ever if ya never taken DNP please dont say its impossible#1 it was back in 2001 just coming off from bluking up #2 have been training for 13 years and competed 6 years #4 It is not very unlikely its true as for pics need a way to scan would love to show 2002 tampa bay classic photos and 2place in the typhoon bay
so please look before you decide to say thats impossible there are many extrem bodybuilders and i happen to be one of them always pushing the limits and cycles beyond most becasue a bodybuilder that stands on stage will tell you that you never look good enough you may stand out in the gym with guys that look ok but when on stage with 25 other guys depending on your weight class who train every day like you only ONE TAKES OVER ALL, ONLY ONE WINS and that guy is the extrem bodbuilder pushing his limits so if you cant beleive it than well than sorry
so please look before you decide to say thats impossible there are many extrem bodybuilders and i happen to be one of them always pushing the limits and cycles beyond most becasue a bodybuilder that stands on stage will tell you that you never look good enough you may stand out in the gym with guys that look ok but when on stage with 25 other guys depending on your weight class who train every day like you only ONE TAKES OVER ALL, ONLY ONE WINS and that guy is the extrem bodbuilder pushing his limits so if you cant beleive it than well than sorry
Whacked
New member
....so your name is LLoyd Dollar (because that's who won the 2002 Tampa Bay Classic)
http://www.southernmuscleplus.com/08-02/thismonth.htm#story4
http://www.southernmuscleplus.com/08-02/thismonth.htm#story4
GoldenDelicious
New member
your statement implies that since DNP has a measurable physiologic action on mitochondria, it may damage them, and since hepatocytes are dense in mitochondria, the liver is at greater risk of toxicity?x_muscle said:
1) where is the association between site of action and harm
2) are you sure that mitochondrial density is greater in the liver?
logically, extended cycles of dnp are going to show possible electrolyte disturbances, likely thyroid depression, elevated cortisol, high creatinine and perhaps some other blood dyscrasias etc etc but id be quite curious to see the results in a real patient myself...
GoldenDelicious
New member
lol ive been in the next room...been a bit worried posting here because my inbox fills up and ill probably end up being sued for somethingkbrkbr said:
DNP or any oxidative uncopuler destroys the membrane - or at very small concentrations destoyed - the proton gradient change I in the inner part of mitochondrial membrane. Cells continue to oxidize food molecules to feed electrons into the electron-transport chin, but H+ ions pumped across the membrane flow back into the mitochondria in futile cycle. Their energy cannot be tapped to drive ATV synthesis, and hence is released as heat. Patients who have been given small doses of DNP lose weight because their fat reserves are used more rapidly to feed the electron-transport chain, and the whole process simply “wastes” energy.
A similar mechanism of heat production I used by specialized tissue composed of brown fat cells, which is abundant in newborn humans and in hibernating animals. These cells are packed with mitochondria that leak part of their H+ gradient futilely back across the membrane for the sole purpose of warming up the organism. These cells are brown because they are packed with mitochondria, which contain high concentrations of pigmented proteins, such as cytochromes.
The DNP collapses the electrochemical proton gradient completely. H+ ions that are pumped to one side of the membrane flow back freely, and therefore no energy can be stored across the membrane.
An electrochemical gradient is made up of two components: a concentration gradient and an electrical potential. If the membrane is made permeable to K+ with migraine, K+ will be driven into the matrix by the electrical potential of the inner membrane ( negative inside, positive outside). The influx of positively charged K+ will abolish the membrane’s electrical potential . In contrast, the concentration component of the H+ gradient ( the PH difference ) is unaffected by ingrain. Therefore, only part of the driving force that makes it energetically favorable for H+ ions to flow back into the matrix is lost.
Dinitrophenols are toxic to the liver, kidney and nervous system. I worked in a microbiology lab for a while and we used to use a phenolic compound to sterilize the bench surface. The data safety sheet in the lab contained pages and pages about toxicity of phenols.
A similar mechanism of heat production I used by specialized tissue composed of brown fat cells, which is abundant in newborn humans and in hibernating animals. These cells are packed with mitochondria that leak part of their H+ gradient futilely back across the membrane for the sole purpose of warming up the organism. These cells are brown because they are packed with mitochondria, which contain high concentrations of pigmented proteins, such as cytochromes.
The DNP collapses the electrochemical proton gradient completely. H+ ions that are pumped to one side of the membrane flow back freely, and therefore no energy can be stored across the membrane.
An electrochemical gradient is made up of two components: a concentration gradient and an electrical potential. If the membrane is made permeable to K+ with migraine, K+ will be driven into the matrix by the electrical potential of the inner membrane ( negative inside, positive outside). The influx of positively charged K+ will abolish the membrane’s electrical potential . In contrast, the concentration component of the H+ gradient ( the PH difference ) is unaffected by ingrain. Therefore, only part of the driving force that makes it energetically favorable for H+ ions to flow back into the matrix is lost.
Dinitrophenols are toxic to the liver, kidney and nervous system. I worked in a microbiology lab for a while and we used to use a phenolic compound to sterilize the bench surface. The data safety sheet in the lab contained pages and pages about toxicity of phenols.
Glycogenolysis in the rat isolated perfused liver as a measure of chemically induced liver toxicity.
Nishihata T, Ikawa C, Saitoh Y, Sakai K.
Pharmaceutical Chemistry Department, University of Kansas, Lawerence 66046.
The relationship between chemically induced glycogenolysis and decreased thiol content in the rat isolated, perfused liver has been examined. Chemicals such as 2,4-dinitrophenol (DNP), diethyl maleate, alcohols and anti-inflammatory agents (except for sodium salicylate) accelerated glycogenolysis. Protein thiol loss correlated well with a marked increased rate of glucose release. Non-protein thiol loss, without significant loss of protein thiol, caused by a slight increase in the rate of glycogenolysis compared with controls. Since it has been reported that protein thiol loss rather than non-protein thiol loss is correlated to liver cell injury, a marked glucose release from the perfused liver may be a convenient measure of hepatic toxicity for a variety of chemicals.
Nishihata T, Ikawa C, Saitoh Y, Sakai K.
Pharmaceutical Chemistry Department, University of Kansas, Lawerence 66046.
The relationship between chemically induced glycogenolysis and decreased thiol content in the rat isolated, perfused liver has been examined. Chemicals such as 2,4-dinitrophenol (DNP), diethyl maleate, alcohols and anti-inflammatory agents (except for sodium salicylate) accelerated glycogenolysis. Protein thiol loss correlated well with a marked increased rate of glucose release. Non-protein thiol loss, without significant loss of protein thiol, caused by a slight increase in the rate of glycogenolysis compared with controls. Since it has been reported that protein thiol loss rather than non-protein thiol loss is correlated to liver cell injury, a marked glucose release from the perfused liver may be a convenient measure of hepatic toxicity for a variety of chemicals.
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