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b6 antiprolactin
- Thread starter Thom
- Start date
VictorBR
New member
Thom said:Hi
In what doses is B6 an effective antioprolactin?
How is it compared to bromo?
I can't get my hands on dostinex or cabaser, so it has to be one of these two. And I don't like the sides I get from bromo!
thanks
thom
>>> Try to get some dostinex bro , it is expensive but well worth it . I have heard that b6 will not work that well ...
Victor
Last edited:
John C Calhoun
New member
I read that between 300-600 mg/day vitamin b6 is typically used for women with severe overproduction of prolactin. Fairly large doses of zinc have also been shown to help lower prolactin levels. If you can get bromocriptine this works very well too but only use it sparingly as it makes most people sick as a dog. The brand name for bromocriptine is parlodel and usually comes in white 5 mg tablets.
Goodfellow
New member
i hate bromo.
junk
New member
Thom said:
Bro, read my posts, I know my shit about Dostinex from A to Z. Been using
it lots of times for it's a terrific drug.
Lowers prolactin - You need that with FINA, DECA and DROL
Strong dopaminic effect - Makes you feel good
Evidance exists that it may raise leptin levels - Great when dieting
Excellent libido boost
And many more benefits really.
I've been using Buy-Dostinex.com for almost all of the times and their
service is top notch. very fast and it's the real thing. Many bros here use
them. Some who used other who were 'cheaper' got scammed so I go
with a winning horse here.
I know this site buy-dostinex.com has started offering cabaser as well
at excellent prices (can't remember the price). But you need to email
them cause they didn't put up it on the site. Cabaser is cheaper and that's
probably what I will get myself from them on next time (still got 7 dostinex
tabs left).
I hope that helps. And if it does hit me with karma
ask any question regarding dostinex I'll be glad to answer.
I wouldn't go with B6 at extreme doses. It is not strong enough against
fina in most cases and Prolactin is one nasty hormone that only brings
troubles (especially in men).
Take care
Junk
VictorBR
New member
junk said:Bro, read my posts, I know my shit about Dostinex from A to Z. Been using
it lots of times for it's a terrific drug.
Lowers prolactin - You need that with FINA, DECA and DROL
Strong dopaminic effect - Makes you feel good
Evidance exists that it may raise leptin levels - Great when dieting
Excellent libido boost
And many more benefits really.
I've been using Buy-Dostinex.com for almost all of the times and their
service is top notch. very fast and it's the real thing. Many bros here use
them. Some who used other who were 'cheaper' got scammed so I go
with a winning horse here.
I know this site buy-dostinex.com has started offering cabaser as well
at excellent prices (can't remember the price). But you need to email
them cause they didn't put up it on the site. Cabaser is cheaper and that's
probably what I will get myself from them on next time (still got 7 dostinex
tabs left).
I hope that helps. And if it does hit me with karma
ask any question regarding dostinex I'll be glad to answer.
I wouldn't go with B6 at extreme doses. It is not strong enough against
fina in most cases and Prolactin is one nasty hormone that only brings
troubles (especially in men).
Take care
Junk
>>> Hey junk , what do you say we start a thread together like this : " Dump the damn b6 and bromo and use DOSTINEX only "
and then we tell a mod to make it a sticky
How about that ?
Victor
junk
New member
VictorBR said:>>> Hey junk , what do you say we start a thread together like this : " Dump the damn b6 and bromo and use DOSTINEX only "
and then we tell a mod to make it a sticky
How about that ?
Victor
Sounds good. I'm on Dostinex right now and I feel absolutly great (as great as you can feel on Tren..lol) Unlike others, I also use Dostinex when dieting, I love it's dopaminic effect. And I guess it's contributing to my increased libio even while using 25mg of aromasin a day and 150mg of tren EOD..
VictorBR
New member
junk said:Sounds good. I'm on Dostinex right now and I feel absolutly great (as great as you can feel on Tren..lol) Unlike others, I also use Dostinex when dieting, I love it's dopaminic effect. And I guess it's contributing to my increased libio even while using 25mg of aromasin a day and 150mg of tren EOD..
Yeah , I have never used it but I have done some serious research and it is really good shit . I am gonna use it for my next monster cycle in wich I will use fina from weeks 7 to 12 .
Victor
junk
New member
Thom said:Karama for you Junk!
buy-dostinex.com certanly have cabaser, and hopefully I have it next week
no more bromo!!
Thanks dude.....Karma back at ya.
I think I'll get some Cabaser for me cause since i'm running out of Dostinex and now I'm thinking of maybe extending my Fina cycle since it makes my veins as pop like crazy and I like it. Plus although on about 180mg of Fina EOD or so my libido is fucking through the roof. I even jerked off this morning (extremely rare for) even though I was super tired and slept just a few hours the night before. Dostinex/Cabaser makes me horny as well. I'll post some pics soon as I now looked more ripped than on my avatar.
macrophage69alpha
New member
selegiline is widely available and cheap
split endz
New member
Is there anything wrong with using Dostinex on a regular basis by those of us who are not on juice ? (never taken AAS yet). I would be interested in it for the libido effects and the " quality of life" feelings. I am on 400-600 mg. b6 ed currently, but have noticed no effects.
Triple J
New member
most dopamine enhancing agents will have the counter effect of lowering prolacting ... hence selegiline would likely be of benefit as well. although in this regard not as strong as cabaser or bromo, but probably better than plain B6. by the way B6 would be a synergist with any of them
Maetenloch
New member
After reading some of the links, dostinex sounds like the right choice for preventing progesterone-related gyno. I wonder if it would also speed up the recovery time for deca/tren by keeping prolactin levels down. Anyone have any experience with this?
macrophage69alpha
New member
kbrkbr said:
it can.
it is a MAOi-b which inhibits the breakdown of dopamine
split endz
New member
bump to my question above...
junk
New member
From my own experience:
Selegiline - Didn't experience increased libido
Bromocriptine - Felt like shit most of the time
B6 - Tried it once for a short duration didn't notice much
My winner is Dostinex (or cabaser/cabergoline)
I can't over emphesize in the increase in sex drive. a thing that should
be quite rare with my large Tren dosages. So Dostinex didn't just keep away the gyno
possibility from Fina, but it increased my libido substantially. One tab (0.5mg) every 4th day works wonders. I posted a link where you can buy cabaser which is identical substance to Dostinex (cabergoline), only the price i posted about it comes down to something like $35 for a month supply of cabaser so I think it's pretty damn cheap for increasing your libido and keeping fina possible gyno away. Damn, I think even the price I paid for the real dostinex previouly is well worth it, but everyone's got different priorities I guess
Selegiline - Didn't experience increased libido
Bromocriptine - Felt like shit most of the time
B6 - Tried it once for a short duration didn't notice much
My winner is Dostinex (or cabaser/cabergoline)
I can't over emphesize in the increase in sex drive. a thing that should
be quite rare with my large Tren dosages. So Dostinex didn't just keep away the gyno
possibility from Fina, but it increased my libido substantially. One tab (0.5mg) every 4th day works wonders. I posted a link where you can buy cabaser which is identical substance to Dostinex (cabergoline), only the price i posted about it comes down to something like $35 for a month supply of cabaser so I think it's pretty damn cheap for increasing your libido and keeping fina possible gyno away. Damn, I think even the price I paid for the real dostinex previouly is well worth it, but everyone's got different priorities I guess
Nighthawkk
New member
junk, where do you see on buy-dostinex.com the generic cabaser/cabergoline offered? I only see the dostinex available there
Nighthawkk
New member
kbrkbr said:
I don't see it on the product list....?
celica
New member
aka SELEGILINE
The "official approved use" of Deprenyl is to treat Parkinson's disease, (because this is a disease that affects the brain levels of dopamine), but it is also being used more and more in other dementias and even cancers. Parkinson and Alzheimer's disease patients are often treated with very high doses of 20mg daily, (often along with other drugs of course). Anti-aging doses, (dependant on age and condition) are more likely to be 2.5mg to 5mg once, twice or three times a week, or better still 1mg to 3mg per day, with regular breaks.
Deprenyl tablets are selegiline hydrochloride, which is deprenyl bonded to an in-organic molecule. However, liquid deprenyl citrate (LDC) is selegiline bonded to an organic molecule, one reason why the liquid deprenyl citrate is considered to be superior. This form is generally recognized as the most pure and potent form of deprenyl available. It also allows precise titration for anti-aging purposes, as each ml drop in the bottle is equivalent to 1mg deprenyl citrate. The manufacturer recommends 1mg two times a week for 30 to 35 years olds up to 10mg daily for 80 year olds plus (an age/ dosage list in English is enclosed with order). Ward Dean, M.D., recommends reducing deprenyl doses after several months to lower levels and taking occasional sabbaticals.
"L-deprenyl is what good pharmaceuticals are all about. First it is exceptionally safe, second it protects and enhances mental function, mood and even libido, thirdly, it may even extend life. Imagine a safe agent that enhances both the quality and length of life."
Julian Whitaker M.D. Health and Healing Newsletter, Whitaker Wellness Institute, Newport Beach, California.
"Many of us here in the States appreciate you making it possible for us to continue to get access to liquid deprenyl."
R.S., New Mexico.
Benefits of the preventive use of Selepryl:
Selepryl protects against age related deterioration in the substantia nigra, the part of the brain where dopamine is produced. This crucial neurotransmitter is responsible for the primary functions such as sexual behavior, fine motor control, immunological function and motivation.
It is effective in the prevention and treatment of Parkinson's and Alzheimer's disease.
To Dr. Knoll, the studies of humans with Parkinson's disease, as well as his studies on rats, all lead to one conclusion: "We now have a safe, selectively acting drug, that for the first time can slow down the most rapidly aging neuronal machinery in our brain".
The unique antioxidant properties of Selepryl protect brain cells from deteriorating over time.
The latest study on rats by the University of Toronto revealed that Selegiline may delay the aging of other organs, in addition to the brain, and has a protective effect on kidney function.
Selepryl counteracts the depressive emotional conditions that are frequent in patients suffering from degenerative diseases, such as cancer, chronic fatigue, diabetes, lupus erythematosus, arthritis, etc.
Other tests have demonstrated that Selepryl dramatically increases the motor ability, awareness, activity and the general well being of elder people. It may also be effective in the treatment of multiple sclerosis.
When Dr. Knoll's research was later duplicated by scientists at the University of Toronto, further evidence was provided that Selegiline can increase the average life span.
Selepryl has no side effects in daily doses of 10 mg or less.
Conclusion:
Recent studies in both animals and humans have demonstrated that Selegiline has a variety of beneficial results against the deterioration of the brain due to aging, without toxic side effects. There is now evidence of the effectiveness of this drug as an antidepressant, of its benefits as an adjuvant in the treatment of Parkinson's disease, its encouraging results for Alzheimer's disease, and in anti aging and libido enhancement.
Selepryl solution is available in 12 ml bottles. 1 mg equals to 1 drop. If dosage is more than 5 mg/ day, divide by two (morning and afternoon).
Quality of life usage indications and dosages:
Parkinson's Disease: Indicated as a treatment adjuvant. Dosage: 5 mg in the morning and 5 mg in the afternoon.
Alzheimer's Disease: May be helpful in treatment. Dosage: 5 mg in the morning and 5 mg in the afternoon.
Tremors: Helpful in the relief of symptoms. Dosage: 5 mg in the morning and 5 mg in the afternoon, for 30 days. For maintenance, reduce amount by I mg per day until reaching proper dose for age. If tremors return, increase dose by I mg a day, until they disappear again, and continue at that dosage. Do not exceed 10 mg per day.
High Blood Pressure: Effective in hypertension reduction. Dosage: 5 mg in the morning and 5 mg in the afternoon, for 30 days. After this period, reduce amount by I mg per day until reaching proper dose for age. If high blood pressure returns, increase dose by I mg a day, until it disappears again, and continue at that dosage. Do not exceed 10 mg per day.
Motion Sickness: Dosage: from 5 to 10 mg a day.
Depression: Dosage: 5 mg in the morning and 5 mg in the afternoon, for 30 days. After this period, reduce amount by 1 mg per day until reaching proper dose for age. If depression returns, increase dose by 1 mg a day, until it disappears again, and continue at that dosage. Do not exceed 10 mg a day.
I used 1mg every 4 days because of being 33 yrs of age. The older you are the more you need , but never more than 6mg a day!
Great for pre sex 2-3mg 1 1/2 hr before sex,,,,,,,,,,works wonders
The "official approved use" of Deprenyl is to treat Parkinson's disease, (because this is a disease that affects the brain levels of dopamine), but it is also being used more and more in other dementias and even cancers. Parkinson and Alzheimer's disease patients are often treated with very high doses of 20mg daily, (often along with other drugs of course). Anti-aging doses, (dependant on age and condition) are more likely to be 2.5mg to 5mg once, twice or three times a week, or better still 1mg to 3mg per day, with regular breaks.
Deprenyl tablets are selegiline hydrochloride, which is deprenyl bonded to an in-organic molecule. However, liquid deprenyl citrate (LDC) is selegiline bonded to an organic molecule, one reason why the liquid deprenyl citrate is considered to be superior. This form is generally recognized as the most pure and potent form of deprenyl available. It also allows precise titration for anti-aging purposes, as each ml drop in the bottle is equivalent to 1mg deprenyl citrate. The manufacturer recommends 1mg two times a week for 30 to 35 years olds up to 10mg daily for 80 year olds plus (an age/ dosage list in English is enclosed with order). Ward Dean, M.D., recommends reducing deprenyl doses after several months to lower levels and taking occasional sabbaticals.
"L-deprenyl is what good pharmaceuticals are all about. First it is exceptionally safe, second it protects and enhances mental function, mood and even libido, thirdly, it may even extend life. Imagine a safe agent that enhances both the quality and length of life."
Julian Whitaker M.D. Health and Healing Newsletter, Whitaker Wellness Institute, Newport Beach, California.
"Many of us here in the States appreciate you making it possible for us to continue to get access to liquid deprenyl."
R.S., New Mexico.
Benefits of the preventive use of Selepryl:
Selepryl protects against age related deterioration in the substantia nigra, the part of the brain where dopamine is produced. This crucial neurotransmitter is responsible for the primary functions such as sexual behavior, fine motor control, immunological function and motivation.
It is effective in the prevention and treatment of Parkinson's and Alzheimer's disease.
To Dr. Knoll, the studies of humans with Parkinson's disease, as well as his studies on rats, all lead to one conclusion: "We now have a safe, selectively acting drug, that for the first time can slow down the most rapidly aging neuronal machinery in our brain".
The unique antioxidant properties of Selepryl protect brain cells from deteriorating over time.
The latest study on rats by the University of Toronto revealed that Selegiline may delay the aging of other organs, in addition to the brain, and has a protective effect on kidney function.
Selepryl counteracts the depressive emotional conditions that are frequent in patients suffering from degenerative diseases, such as cancer, chronic fatigue, diabetes, lupus erythematosus, arthritis, etc.
Other tests have demonstrated that Selepryl dramatically increases the motor ability, awareness, activity and the general well being of elder people. It may also be effective in the treatment of multiple sclerosis.
When Dr. Knoll's research was later duplicated by scientists at the University of Toronto, further evidence was provided that Selegiline can increase the average life span.
Selepryl has no side effects in daily doses of 10 mg or less.
Conclusion:
Recent studies in both animals and humans have demonstrated that Selegiline has a variety of beneficial results against the deterioration of the brain due to aging, without toxic side effects. There is now evidence of the effectiveness of this drug as an antidepressant, of its benefits as an adjuvant in the treatment of Parkinson's disease, its encouraging results for Alzheimer's disease, and in anti aging and libido enhancement.
Selepryl solution is available in 12 ml bottles. 1 mg equals to 1 drop. If dosage is more than 5 mg/ day, divide by two (morning and afternoon).
Quality of life usage indications and dosages:
Parkinson's Disease: Indicated as a treatment adjuvant. Dosage: 5 mg in the morning and 5 mg in the afternoon.
Alzheimer's Disease: May be helpful in treatment. Dosage: 5 mg in the morning and 5 mg in the afternoon.
Tremors: Helpful in the relief of symptoms. Dosage: 5 mg in the morning and 5 mg in the afternoon, for 30 days. For maintenance, reduce amount by I mg per day until reaching proper dose for age. If tremors return, increase dose by I mg a day, until they disappear again, and continue at that dosage. Do not exceed 10 mg per day.
High Blood Pressure: Effective in hypertension reduction. Dosage: 5 mg in the morning and 5 mg in the afternoon, for 30 days. After this period, reduce amount by I mg per day until reaching proper dose for age. If high blood pressure returns, increase dose by I mg a day, until it disappears again, and continue at that dosage. Do not exceed 10 mg per day.
Motion Sickness: Dosage: from 5 to 10 mg a day.
Depression: Dosage: 5 mg in the morning and 5 mg in the afternoon, for 30 days. After this period, reduce amount by 1 mg per day until reaching proper dose for age. If depression returns, increase dose by 1 mg a day, until it disappears again, and continue at that dosage. Do not exceed 10 mg a day.
I used 1mg every 4 days because of being 33 yrs of age. The older you are the more you need , but never more than 6mg a day!
Great for pre sex 2-3mg 1 1/2 hr before sex,,,,,,,,,,works wonders
Nighthawkk said:
It's the very first product under the "C" category. You can't miss it.
The first time I bought from them, I got the 4mg tab, but cutting it down to .5 mg was a pain, even using a pill cutter, so I ground it up and suspended it in 151, just like I do my var. Measures out quite nicely at a fraction of the price you pay at buy-dostinex.com.
junk
New member
Nighthawkk said:
I've heard of two cases of people who ordered from mastersmarketing (i don't recall what it was) and their packages were seized by customs. apparently mastersmarketing packing is not discreet enough or so(??)
I've had great experience with buy-dostinex as their packaging is very discreet. anyway with their now offering cabaser i may try it as their cabaser comes about 5 times cheaper than dostinex. email buy-dostinex it's not on their site.
celica
New member
In the early 1960's Professor Joseph Knoll of Semmelweis University in Hungary developed the medication Deprenyl for use as an anti-depressant. Later the drug was found to benefit Parkinson's patients due to it's ability to regulate neurotransmitters such as dopamine. Parkinson's is thought to be caused by low-production of dopamine. Dopamine production in such patients decreases by 30% to 90% per decade, and when production has fallen to 10% of normal the patient dies within a short time. Dopamine production also decreases in healthy people, but at a slower rate of about 13% per decade in normally aging people and only 8% in slowly aging people. However, the difference in Parkinson's patients and healthy people is only a matter of rate of decline and time. A study done in 1988 by Professor Knoll showed that rats given medium does of Deprenyl live up to thirty percent longer because the drug slows this loss of dopamine. Later experiments also showed increased life-span, although not as high a percent as the 1988 experiment found.
Originally, the drug was thought to work only as an MAO-inhibitor (MAO, or monoamine oxidase, is the neurotransmitter that metabolizes used neurotransmitters). When MAO-levels rise, as they do as a person ages, levels of neurotransmitters such as dopamine, decrease. MAO-inhibitors help stabilize levels of neurotransmitters and thus slow aging. However, research from 1994 shows Deprenyl has benefits unconnected with its MAO-inhibiting action. Deprenyl also acts as an anti-oxidant and stimulates production of the body's natural anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT). These effects also slow aging.
Professor Joseph Knoll, discover of the pharmacological activity of Deprenyl
Parkinson's disease is currently the only FDA approved use of the drug, but there is on-going research on its use to treat Alzheimer's. Anecdotal evidence indicates that Deprenyl may be effective in treating stoke, dementia, multiple scelrosis, and hypertension, and a number of other conditions. Dr. Clyde Reynolds, a specialist in metabolic cancer therapy in Washington State, discovered that cancer patients consistently have imbalances in the neurotransmitters epinephrine, norepinephrine, and serotonin and the balance must be restored if patients are to be cured. This is possibly due to Deprenyls ability to increase DHEA levels, which are important in maintaining the immune system.
Another benefit of Deprenyl is its aphrodisiac effect and its ability to increase sensitivity of touch. Research done by Professor Knoll in 1993 found increased mating frequency in rats and incidental evidence from those people taking Deprenyl concurs.
Healthy individuals looking at Deprenyl for life-extension purposes are advised moderate doses. Over the long term, proper dosage appears to be a crucial factor and research is underway to pin-point optimum dosage. Very high doses are not advised for healthy people. The following rate is currently recommended for starting dosage and should be lowered after several months of treatment:
Deprenil recomended rates
Age Dosage Age Dosage
30-35 1mg twice a week 60-65 5 mg every day
35-40 1mg every other day 65-70 6mg every day
40-45 1mg every day 70-75 8mg every day
45-50 2mg every day 75-80 9mg every day
55-60 3mg every day 80 and over 10mg every day
Selected references on Deprenyl:
Mech Ageing Dev 1988 Dec;46(1-3):237-62
The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl.
Knoll J.
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Long-term experiments on male rats revealed that better performers in the mating test are better learners in the shuttle box and the more active animals live significantly longer than their less active peers. It was established by the aid of (-)deprenyl, a highly specific chemical tool, which increases superoxide dismutase activity in the striatum, facilitates the activity of the nigrostriatal dopaminergic neurons with utmost selectivity, and protects these neurons from their age-related decay, that the efficiency of a male rat in behavioral tests, as well as the duration of its life are striatal dopamine dependent functions. As a measure of striatal function, sexual activity was tested once a week in a group of male rats (n = 132) from the 24th month of their life. Because of the age-related decay of this function none of the 2-year-old animals displayed full scale sexual activity. By dividing the group equally the rats were treated with saline (1 ml/kg, s.c.) and deprenyl (0.25 mg/kg, s.c.), respectively, three times a week. In the saline-treated group (n = 66) the last signs of sexual activity vanished to the 33rd week of treatment. (-)Deprenyl treatment restored full scale sexual activity in 64 out of 66 rats. The longest living rat in the saline-treated group lived 164 weeks. The average lifespan of the group was 147.05 +/- 0.56 weeks. The shortest living animal in the (-)deprenyl-treated group lived 171 weeks and the longest living rat died during the 226th week of its life. The average lifespan was 197.98 +/- 2.36 weeks, i.e. higher than the estimated maximum age of death in the rat (182 weeks). This is the first instance that by the aid of a well-aimed medication members of a species lived beyond the known lifespan maximum.
Ann N Y Acad Sci 1994 Jun 30;717:60-71 (-)
Deprenyl increases the life span as well as activities of superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions in Fischer rats.
Kitani K, Kanai S, Carrillo MC, Ivy GO.
Radioisotope Research Institute, Faculty of Medicine, University of Tokyo, Japan.
(-)Deprenyl, a MAO-B inhibitor that is also known to be effective for symptoms of Parkinson's disease, when injected subcutaneously (sc) in male Fischer-344 rats at a dose of 0.5 mg/kg per day (3 times a week) from 18 months of age, significantly increased the remaining life expectancy. The average life span after 24 months was 34% greater in treated rats than in saline-treated control animals. Furthermore, a short-term (3 wk) continuous sc infusion of deprenyl significantly increased activities of superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions such as s. nigra, striatum, and cerebral cortex, but not in hippocampus or cerebellum, or the liver. The optimal dose for increasing these activities, however, differed greatly depending on the sex and age of animals, with a 10-fold lower value for young female than male rats. Interestingly, aging caused an increase and a decrease in the optimal dose in female and male rats, respectively. In addition, treatment for a longer term tended to reduce the optimal dosage in the same animal group. The results clearly demonstrate that deprenyl increases antioxidant enzyme activities in selective brain regions. If this effect of deprenyl is causally related to its life-prolonging effect, the dosage to be used for any life span study would be a critical factor, with the dosage differing widely depending on sex, age of animal, and mode and duration of drug administration.
Acta Physiol Hung 1996;84(3):277-8
Longevity treatment with (-)deprenyl in female rats: effect on copulatory activity and lifespan.
Dallo J, Koles L.
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Six months old ovariectomized female rats (n = 9) were treated with (-)deprenyl in a dose of 0.25 mg/kg s.c. three times a week, and (n = 9) with physiologic saline (0.1 ml/100 g) till decay. It was found that control females (n = 9) decayed within the age of fifteen months while the members of the (-)deprenyl treated group were all alive at that age. Moreover three (-)deprenyl treated female rats reached 36 months of age. Sexual activity was quite absent in both groups. The data suggests that (-)deprenyl extended the lifespan of female rats only in total absence of gonadal hormones and sexual activity.
Mech Ageing Dev 2002 Apr;123(8):1087-100
Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects.
Kitani K, Minami C, Isobe K, Maehara K, Kanai S, Ivy GO, Carrillo MC.
National Institute for Longevity Sciences, 36-3, Gengo, Morioka-cho, Obu-shi, 474-8522, Aichi, Japan.
(-)Deprenyl, a monoamine oxidase B (MAO B) inhibitor is known to upregulate activities of anti-oxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) in brain dopaminergic regions. The drug is also the sole chemical which has been repeatedly shown to increase life spans of several animal species including rats, mice, hamsters and dogs. Further, the drug was recently found to enhance anti-oxidant enzyme activities not only in brain dopaminergic regions but also in extra-brain tissues such as the heart, kidneys, adrenal glands and the spleen. We and others have also observed mobilization of many humoral factors (interferone (INF)-gamma, tumor necrosis factor (TNF)-alpha, interleukine (IL)-1beta,2,6, trophic factors, etc.) and enhancement of natural killer (NK) cell functions by (-)deprenyl administration. An apparent extension of life spans of experimental animals reported in the past may be better explained by these new observations that (-)deprenyl upregulate SOD and CAT activities not only in the brain but also in extra-brain vital organs and involve anti-tumorigenic as well as immunomodulatory effect as well. These combined drug effects may lead to the protection of the homeostatic regulations of the neuro-immuno-endocrine axis of an organism against aging.
Contents
Selected references on Deprenyl
Deprenyl: order now
Originally, the drug was thought to work only as an MAO-inhibitor (MAO, or monoamine oxidase, is the neurotransmitter that metabolizes used neurotransmitters). When MAO-levels rise, as they do as a person ages, levels of neurotransmitters such as dopamine, decrease. MAO-inhibitors help stabilize levels of neurotransmitters and thus slow aging. However, research from 1994 shows Deprenyl has benefits unconnected with its MAO-inhibiting action. Deprenyl also acts as an anti-oxidant and stimulates production of the body's natural anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT). These effects also slow aging.
Professor Joseph Knoll, discover of the pharmacological activity of Deprenyl
Parkinson's disease is currently the only FDA approved use of the drug, but there is on-going research on its use to treat Alzheimer's. Anecdotal evidence indicates that Deprenyl may be effective in treating stoke, dementia, multiple scelrosis, and hypertension, and a number of other conditions. Dr. Clyde Reynolds, a specialist in metabolic cancer therapy in Washington State, discovered that cancer patients consistently have imbalances in the neurotransmitters epinephrine, norepinephrine, and serotonin and the balance must be restored if patients are to be cured. This is possibly due to Deprenyls ability to increase DHEA levels, which are important in maintaining the immune system.
Another benefit of Deprenyl is its aphrodisiac effect and its ability to increase sensitivity of touch. Research done by Professor Knoll in 1993 found increased mating frequency in rats and incidental evidence from those people taking Deprenyl concurs.
Healthy individuals looking at Deprenyl for life-extension purposes are advised moderate doses. Over the long term, proper dosage appears to be a crucial factor and research is underway to pin-point optimum dosage. Very high doses are not advised for healthy people. The following rate is currently recommended for starting dosage and should be lowered after several months of treatment:
Deprenil recomended rates
Age Dosage Age Dosage
30-35 1mg twice a week 60-65 5 mg every day
35-40 1mg every other day 65-70 6mg every day
40-45 1mg every day 70-75 8mg every day
45-50 2mg every day 75-80 9mg every day
55-60 3mg every day 80 and over 10mg every day
Selected references on Deprenyl:
Mech Ageing Dev 1988 Dec;46(1-3):237-62
The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl.
Knoll J.
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Long-term experiments on male rats revealed that better performers in the mating test are better learners in the shuttle box and the more active animals live significantly longer than their less active peers. It was established by the aid of (-)deprenyl, a highly specific chemical tool, which increases superoxide dismutase activity in the striatum, facilitates the activity of the nigrostriatal dopaminergic neurons with utmost selectivity, and protects these neurons from their age-related decay, that the efficiency of a male rat in behavioral tests, as well as the duration of its life are striatal dopamine dependent functions. As a measure of striatal function, sexual activity was tested once a week in a group of male rats (n = 132) from the 24th month of their life. Because of the age-related decay of this function none of the 2-year-old animals displayed full scale sexual activity. By dividing the group equally the rats were treated with saline (1 ml/kg, s.c.) and deprenyl (0.25 mg/kg, s.c.), respectively, three times a week. In the saline-treated group (n = 66) the last signs of sexual activity vanished to the 33rd week of treatment. (-)Deprenyl treatment restored full scale sexual activity in 64 out of 66 rats. The longest living rat in the saline-treated group lived 164 weeks. The average lifespan of the group was 147.05 +/- 0.56 weeks. The shortest living animal in the (-)deprenyl-treated group lived 171 weeks and the longest living rat died during the 226th week of its life. The average lifespan was 197.98 +/- 2.36 weeks, i.e. higher than the estimated maximum age of death in the rat (182 weeks). This is the first instance that by the aid of a well-aimed medication members of a species lived beyond the known lifespan maximum.
Ann N Y Acad Sci 1994 Jun 30;717:60-71 (-)
Deprenyl increases the life span as well as activities of superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions in Fischer rats.
Kitani K, Kanai S, Carrillo MC, Ivy GO.
Radioisotope Research Institute, Faculty of Medicine, University of Tokyo, Japan.
(-)Deprenyl, a MAO-B inhibitor that is also known to be effective for symptoms of Parkinson's disease, when injected subcutaneously (sc) in male Fischer-344 rats at a dose of 0.5 mg/kg per day (3 times a week) from 18 months of age, significantly increased the remaining life expectancy. The average life span after 24 months was 34% greater in treated rats than in saline-treated control animals. Furthermore, a short-term (3 wk) continuous sc infusion of deprenyl significantly increased activities of superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions such as s. nigra, striatum, and cerebral cortex, but not in hippocampus or cerebellum, or the liver. The optimal dose for increasing these activities, however, differed greatly depending on the sex and age of animals, with a 10-fold lower value for young female than male rats. Interestingly, aging caused an increase and a decrease in the optimal dose in female and male rats, respectively. In addition, treatment for a longer term tended to reduce the optimal dosage in the same animal group. The results clearly demonstrate that deprenyl increases antioxidant enzyme activities in selective brain regions. If this effect of deprenyl is causally related to its life-prolonging effect, the dosage to be used for any life span study would be a critical factor, with the dosage differing widely depending on sex, age of animal, and mode and duration of drug administration.
Acta Physiol Hung 1996;84(3):277-8
Longevity treatment with (-)deprenyl in female rats: effect on copulatory activity and lifespan.
Dallo J, Koles L.
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Six months old ovariectomized female rats (n = 9) were treated with (-)deprenyl in a dose of 0.25 mg/kg s.c. three times a week, and (n = 9) with physiologic saline (0.1 ml/100 g) till decay. It was found that control females (n = 9) decayed within the age of fifteen months while the members of the (-)deprenyl treated group were all alive at that age. Moreover three (-)deprenyl treated female rats reached 36 months of age. Sexual activity was quite absent in both groups. The data suggests that (-)deprenyl extended the lifespan of female rats only in total absence of gonadal hormones and sexual activity.
Mech Ageing Dev 2002 Apr;123(8):1087-100
Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects.
Kitani K, Minami C, Isobe K, Maehara K, Kanai S, Ivy GO, Carrillo MC.
National Institute for Longevity Sciences, 36-3, Gengo, Morioka-cho, Obu-shi, 474-8522, Aichi, Japan.
(-)Deprenyl, a monoamine oxidase B (MAO B) inhibitor is known to upregulate activities of anti-oxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) in brain dopaminergic regions. The drug is also the sole chemical which has been repeatedly shown to increase life spans of several animal species including rats, mice, hamsters and dogs. Further, the drug was recently found to enhance anti-oxidant enzyme activities not only in brain dopaminergic regions but also in extra-brain tissues such as the heart, kidneys, adrenal glands and the spleen. We and others have also observed mobilization of many humoral factors (interferone (INF)-gamma, tumor necrosis factor (TNF)-alpha, interleukine (IL)-1beta,2,6, trophic factors, etc.) and enhancement of natural killer (NK) cell functions by (-)deprenyl administration. An apparent extension of life spans of experimental animals reported in the past may be better explained by these new observations that (-)deprenyl upregulate SOD and CAT activities not only in the brain but also in extra-brain vital organs and involve anti-tumorigenic as well as immunomodulatory effect as well. These combined drug effects may lead to the protection of the homeostatic regulations of the neuro-immuno-endocrine axis of an organism against aging.
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Thom
New member
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junk
New member
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