Avandia: who's used it?

[drveejay11]

Thoughts?

 

[benevolent anarchist]

I’m using rHGH and am interested as well. {bump}

 

[poantrex]

Avandia will help insulin sensitivity by a great deal, but 90% of people using this drug will experience weight gain - on the plus side though, you'll gain fat evenly over the body - it won't be isolated to peripheral areas like the stomach and love handles. Just do a quick search on google groups with the keyword "avandia" or "actos" and you'll see tons of people mentioning this as a side effect.

Now i'm sure that many of these people are sedentary and don't practice proper nutrition, and the above drugs may excaserbate this effect...but I decided not to risk it. I love my 6 pack.

 

[poantrex]

I’m using rHGH and am interested as well. {bump}

Careful, clinical insulin resistance has been in observed in many patients using exo-GH. My understanding is, while using GH..insulin cannot properly dispose of blood glucose - which causes more insulin to be released for prolonged amounts of time - this will eventually contribute to the "burning out" of the beta cells in the pancreas. At the very least I would run a good dose of glucophage 2x a day - glucophage helps slow the release of glucose from the liver, therefore helping insulin sensitivity of the liver only - even though its limited it does usually manage to help keep blood glucose levels in check.

 

[benevolent anarchist]

Careful, clinical insulin resistance has been in observed in many patients using exo-GH. My understanding is, while using GH..insulin cannot properly dispose of blood glucose - which causes more insulin to be released for prolonged amounts of time - this will eventually contribute to the "burning out" of the beta cells in the pancreas. At the very least I would run a good dose of glucophage 2x a day - glucophage helps slow the release of glucose from the liver, therefore helping insulin sensitivity of the liver only - even though its limited it does usually manage to help keep blood glucose levels in check.

Thanks. I’ve tried glucophage, but didn’t like the way it made me feel, so I stopped after only three days. Maybe the queasy feeling will subside after a week. Right now I’m just taking 2 grams of Glucorell per day.

 

[poantrex]

Hmm, glucorell will definitely help but I still don't fully understand its method of glucose disposal (anyone?). Either way, monitoring your blood sugar is a good idea.

 

[benevolent anarchist]

poantrex et al: Regarding glucophage (metformin), have you read this study?

Saudi Med J 2002 Aug;23(8):934-7
Effects of short term metformin administration on androgens in normal men.
Shegem NS, Nasir AM, Jbour AK, Batieha AM, El-Khateeb MS, Ajlouni KM.
National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan.

OBJECTIVE: To study the effect of metformin on androgens in normal men.

METHODS: A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin.

RESULTS: After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure.

CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.

I’m wondering how significant this is to the majority of us who are using exogenous testosterone. I’m assuming it would be relevant since it raises SHBG.

drveejay11: sorry to highjack your thread. I hope you’re finding some of this information useful.

 

[Fonz]

Glucorrel-R at high dosages(1000-2000mg/day) is enough to off-set the insulin resistance generated by GH.

I'm at 4.5IU's/day GH and haven't had any problems.

Fonz

 

[benevolent anarchist]

Glucorrel-R at high dosages(1000-2000mg/day) is enough to off-set the insulin resistance generated by GH.

I'm at 4.5IU's/day GH and haven't had any problems.

Fonz

Thanks. I’m following your recommendations.