Arimidex VS. Fermera

[Smokescreen]

Which is better at doing it's job?

 

[jeb0177]

femara

 

[jeb0177]

bro, Femara is 10-30x more effective than Arimidex in it's ability to pass thru the cell membrane of lipid (fat) cells and inhibit the activity of romatase -- in other words, Femara is far superior in lowering estrogen levels in fat cells. This has two benefits for BBs; Estrogen 'attracts' water, so less water retention an average male BB is around 10%BF, that's a lot of lipid cells with aromatase inside them, so a substantial percentage of aromatase is left untouched by Arimidex due to it's poor ability to enter lipid cellsArimidex is approximately 80% effective at inhibiting aromatase.

got it?

 

[Smokescreen]

Femara all the way then!!! But what about dosage? 2.5mg per day?

 

[jeb0177]

I take it e3d at 2.5mg, what are buying liquid of pills? I'm taking the liquid and it works pretty well, I'm in 20 weeker cycle of test 500/wk and 400 of EQ and I was running the nolva at 20mg but sometimes I would still feel a bit of sore nips and now with the Letro it's awsome. I highly recommended.

 

[junk]

Aromasin... I know it's just Anastrozole vs Letrozole.. But Aromasin (Exemstane) is by far the best choice... it apparently would not effect lipid profile as much as the other aromatase inhibitors... it would also not give the nasty mental sides that sometimes come with letro. I use Upjohn aromasin..

 

[Fat_Sumo]

Which is better at doing it's job?

Femara is definatly stronger then arimidex but both do good job!

What is your cycle?
How sensitive are you to estrogenic sides?

Femara is a stronger aromatase inhibitor then arimidex but that isn't always a "good thing"!

 

[CLOMIDCLOWN]

Fat Sumo- What do you mean by it isnt always a good thing?

 

[Lift Chief]

Fat Sumo- What do you mean by it isnt always a good thing?

Femara can bring estrogen levels so low that there is a negative effect on the lipid profile. You can avoid this by starting with a low dose of femara and then uping it if need be.

 

[Smokescreen]

I'm currently using 500mg's of Sust per week along with Arimidex. So far estrogenic sides are low. Yes! I am very sensitive to estrogenic side effects. I look at a amp of Test and I blow up with water! But anyways, no gyno so far but I still have a little water retention that I wish to get rid of.

 

[OXANDRIN]

so much of the information on aromatase inhibitors is based on studies in women with breast cancer..... in men lipid profiles and igf1 changes are somewhat unknown.

 

[Lift Chief]

so much of the information on aromatase inhibitors is based on studies in women with breast cancer..... in men lipid profiles and igf1 changes are somewhat unknown.

Unfortunately, i don't think that's really true bro. Guys have done cycles with femara and then had their lipid profiles checked and they've been pretty shitty... more shitty than those just on gear. The anecdotal evidence combined with the scientific evidence seems to imply that it's a real possibility.

 

[OXANDRIN]

The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.

Wickman S, Saukkonen T, Dunkel L.

Hospital for Children and Adolescents, University of Helsinki, PL281, FIN-00029 HUS, Helsinki, Finland. [email protected]

OBJECTIVE: Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS: We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits the conversion of androgens to oestrogens. We demonstrated previously that during treatment with testosterone plus letrozole the increase in testosterone concentration was more than 5-fold higher than during treatment with testosterone plus placebo. The concentrations of 17beta-oestradiol, IGF-I and IGF-binding protein-3 increased during testosterone-plus-placebo treatment, but during testosterone-plus-letrozole treatment the concentrations remained unchanged. These divergent changes in the two groups enabled us to study the effects of sex steroids and GH on insulin sensitivity and lipid concentrations. RESULTS: The insulin concentration in the testosterone-plus-placebo-treated group did not change. In contrast, in the testosterone-plus-letrozole-treated group, the concentration decreased during letrozole treatment, indicating improved insulin sensitivity. Changes in insulin and IGF-I concentrations within 12 and 18 months were correlated. In the testosterone-plus-placebo-treated group, the high-density lipoprotein cholesterol concentration did not change but in the testosterone-plus-letrozole-treated group the concentration decreased. The concentrations of low-density lipoprotein cholesterol (LDL-cholesterol) and triglycerides did not change in either of the groups. CONCLUSIONS: The findings indicate that androgens do not directly alter insulin sensitivity in boys during puberty. In contrast, the observations suggest tight regulation of glucose--insulin homeostasis by GH in boys at this stage. Furthermore, our findings indicate that sex steroids do not significantly participate in the regulation of serum concentrations of LDL-cholesterol or triglycerides in boys during early and mid-puberty.

Publication Types:
Clinical Trial
Randomized Controlled Trial

 

[Fat_Sumo]

hmmmmmm....... I have a lot of studies that state other wise! Interesting read though!

 

[Lift Chief]

The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.

Wickman S, Saukkonen T, Dunkel L.

Hospital for Children and Adolescents, University of Helsinki, PL281, FIN-00029 HUS, Helsinki, Finland. [email protected]

OBJECTIVE: Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS: We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits the conversion of androgens to oestrogens. We demonstrated previously that during treatment with testosterone plus letrozole the increase in testosterone concentration was more than 5-fold higher than during treatment with testosterone plus placebo. The concentrations of 17beta-oestradiol, IGF-I and IGF-binding protein-3 increased during testosterone-plus-placebo treatment, but during testosterone-plus-letrozole treatment the concentrations remained unchanged. These divergent changes in the two groups enabled us to study the effects of sex steroids and GH on insulin sensitivity and lipid concentrations. RESULTS: The insulin concentration in the testosterone-plus-placebo-treated group did not change. In contrast, in the testosterone-plus-letrozole-treated group, the concentration decreased during letrozole treatment, indicating improved insulin sensitivity. Changes in insulin and IGF-I concentrations within 12 and 18 months were correlated. In the testosterone-plus-placebo-treated group, the high-density lipoprotein cholesterol concentration did not change but in the testosterone-plus-letrozole-treated group the concentration decreased. The concentrations of low-density lipoprotein cholesterol (LDL-cholesterol) and triglycerides did not change in either of the groups. CONCLUSIONS: The findings indicate that androgens do not directly alter insulin sensitivity in boys during puberty. In contrast, the observations suggest tight regulation of glucose--insulin homeostasis by GH in boys at this stage. Furthermore, our findings indicate that sex steroids do not significantly participate in the regulation of serum concentrations of LDL-cholesterol or triglycerides in boys during early and mid-puberty.

Publication Types:
Clinical Trial
Randomized Controlled Trial

According to that study ldl remained the same but hdl decreased more with femara than without it... so that indicates a negative effect on lipid profile, likely as a result of femara.