Please Scroll Down to See Forums Below BornAgainPagan
New member
hey any one tried arginine alpha-ketoglutatate or any thing like it and if so did you get any decent results?
arginine alpha-ketoglutarate
- Thread starter BornAgainPagan
- Start date
sawastea
Well-known member
Here are a few studies:
Supplement Alpha-ketoglutarate (AKG)
Description Ornithine alpha-ketoglutarate (OKG) is a salt formed by combining two molecules of the amino acid ornithine and one molecule of alpha-ketoglutarate. Because OKG seems to be involved in amino acid synthesis and protein availability, many athletes supplement with OKG as a way to increase muscle mass and strength – although the evidence for its effectiveness is this regard is quite limited.
Claims Increase muscle size and strength
Reduce body fat
Stimulates the immune system
Theory OKG has been used to treat patients suffering from burns, surgery, malnutrition and other trauma. Although the precise mechanism is unknown, OKG treatment decreases muscle protein catabolism (breakdown) and/or increases protein synthesis, in addition to promoting wound healing. OKG may promote the secretion of anabolic hormones such as insulin and growth hormone and increase amino acid metabolism (glutamine & arginine), which may help explain some of the clinical findings.
Scientific Support Arginine and ornithine are precursors of nitric oxide and polyamines, respectively -metabolites which participate in a number of metabolic functions. OKG supplements have been shown to promote growth hormone and insulin secretion with anabolic effects in postoperative patients. Their intermediary metabolites (glutamine & proline) may also have beneficial effects in promoting recovery from trauma. In animal studies, OKG supplementation increases levels of arginine and glutamine in skeletal muscles and stimulates immune system function compared to animals not receiving OKG. The immunomodulatory properties found with OKG suggest that it may enhance host-defense mechanisms, particularly during injury and acute stress
OKG supplements (15 grams per day for 5 months) have been shown to improve growth rates in small children. The OKG supplements resulted in elevated concentrations of anabolic (growth) hormones and amino acid metabolites, including insulin-like growth factor 1 (IGF1), glutamine and glutamate. In another study of healthy men, OKG given at 10 grams per day resulted in a 20-30% elevation in insulin (another anabolic hormone), which were not observed with supplementation of either ornithine or alpha-ketoglutarate alone.
A test tube study found that OKG induces a significant increase in growth of human fibroblasts – cells with similarities to muscle fiber cells. This effect was dose-dependent, meaning that a more pronounced growth effect was noted with increasing levels of OKG (but not with increasing levels of ornithine or alpha-ketoglutarate alone).
In one study, the anti-catabolic effects of OKG were investigated in 14 multiple trauma patients who were highly catabolic and hyper-metabolic. One group of subjects received 20 grams of OKG per day and showed a significant increase in protein turnover as well as a an increase in blood levels of insulin, growth hormone, and free amino acids (glutamine, proline and ornithine) compared to subjects not receiving OKG supplements.
Safety No apparent side effects have been noted with OKG supplementation at the doses studied (10-15 grams/day), although there have been anecdotal reports of increased appetite – perhaps owing to elevated insulin levels (??).
Value OKG supplements, taken at a dose shown to produce effects (10-15 grams per day) is a fairly expensive regimen. At $30-$35 per 100 capsule bottle (1250 mg capsules), a one month supply will cost over $100. For stimulating increases in muscle mass, creatine may be able to provide the same end benefit – at a much lower cost per day.
Dosage OKG has been used at doses of 10-15 grams per day in healthy men and short-stature children.
References 1. Cochard A, Guilhermet R, Bonneau M. Plasma growth hormone (GH), insulin and amino acid responses to arginine with or without aspartic acid in pigs. Effect of the dose. Reprod Nutr Dev 1998 May-Jun;38(3):331-43.
2. Jeevanandam M, Petersen SR. Substrate fuel kinetics in enterally fed trauma patients supplemented with ornithine alpha ketoglutarate. Clin Nutr 1999 Aug;18(4):209-17
~~~~~~~~~~~~~~~~~~~
ROBERT D. CHETLIN, RACHEL A. YEATER, IRMA H. ULLRICH, W. GUYTON HORNSBY, JR., ¹CARL J. MALANGA, AND RANDALL W. BRYNER. The Effect Of Ornithine Alpha-Ketoglutarate (Okg) On Healthy, Weight Trained Men. JEPonline, 3(4):37-47, 2000. The purposes of this study were to determine if OKG consumption (10 grams/day) improves strength, power and body composition in weight-trained men, and; evaluate OKG-effects on insulin and growth hormone blood concentrations, dietary intake, training intensity and volume. Eighteen resistance-trained men (age range 18-35) participated in a six-week double-blind study. Subjects were randomly assigned to an experimental (n=8) or placebo (n=10) group and were subsequently tested in 1-RM squat, 1-RM bench press, Wingate test, vertical jump, and hydrostatic weighing. After a 12-hour fast, subjects received 75g carbohydrate drinks and either OKG (10 grams) or placebo. Blood samples were obtained at baseline, 30, 60, and 90 minutes and analyzed for growth hormone, insulin and glucose. Subjects recorded their diet and training. Training volumes were similar between groups at study start and conclusion. Baseline dietary data was similar between groups except OKG-group consumed more carbohydrates (329±77g vs. 250±68g, p<0.05). Macronutrient consumption, however, was not different between groups during the experiment. Performance variables were not different between groups during the course of the study. The OKG group had a greater percentage increase in bench press strength (114±9kg vs. 123±2kg, 6.6% increase) versus controls (117±2kg vs. 118±2kg, 1.5 % increase), p<0.05. Strength gains in the squat were not different between groups. Acute training variables (i.e. sets, repetitions, exercise number) declined in both groups, while training intensity increased. Total training volume was not different between groups. No differences were noted between groups in mean levels of insulin or growth hormone after six weeks following OKG challenge. Conclusion: OKG did not alter insulin or growth hormone blood concentrations after six weeks in experienced weight-trained men. OKG does not result in increased training intensity, training volume, or muscle mass in free-living men. OKG effects on strength are unclear since bench press performance improved but squat performance did not.
~~~~~~~~~~~~~~~~~~~~~~
That being said, if you're looking into a product like NO2, you're better off saving your money and making it yourself
Supplement Alpha-ketoglutarate (AKG)
Description Ornithine alpha-ketoglutarate (OKG) is a salt formed by combining two molecules of the amino acid ornithine and one molecule of alpha-ketoglutarate. Because OKG seems to be involved in amino acid synthesis and protein availability, many athletes supplement with OKG as a way to increase muscle mass and strength – although the evidence for its effectiveness is this regard is quite limited.
Claims Increase muscle size and strength
Reduce body fat
Stimulates the immune system
Theory OKG has been used to treat patients suffering from burns, surgery, malnutrition and other trauma. Although the precise mechanism is unknown, OKG treatment decreases muscle protein catabolism (breakdown) and/or increases protein synthesis, in addition to promoting wound healing. OKG may promote the secretion of anabolic hormones such as insulin and growth hormone and increase amino acid metabolism (glutamine & arginine), which may help explain some of the clinical findings.
Scientific Support Arginine and ornithine are precursors of nitric oxide and polyamines, respectively -metabolites which participate in a number of metabolic functions. OKG supplements have been shown to promote growth hormone and insulin secretion with anabolic effects in postoperative patients. Their intermediary metabolites (glutamine & proline) may also have beneficial effects in promoting recovery from trauma. In animal studies, OKG supplementation increases levels of arginine and glutamine in skeletal muscles and stimulates immune system function compared to animals not receiving OKG. The immunomodulatory properties found with OKG suggest that it may enhance host-defense mechanisms, particularly during injury and acute stress
OKG supplements (15 grams per day for 5 months) have been shown to improve growth rates in small children. The OKG supplements resulted in elevated concentrations of anabolic (growth) hormones and amino acid metabolites, including insulin-like growth factor 1 (IGF1), glutamine and glutamate. In another study of healthy men, OKG given at 10 grams per day resulted in a 20-30% elevation in insulin (another anabolic hormone), which were not observed with supplementation of either ornithine or alpha-ketoglutarate alone.
A test tube study found that OKG induces a significant increase in growth of human fibroblasts – cells with similarities to muscle fiber cells. This effect was dose-dependent, meaning that a more pronounced growth effect was noted with increasing levels of OKG (but not with increasing levels of ornithine or alpha-ketoglutarate alone).
In one study, the anti-catabolic effects of OKG were investigated in 14 multiple trauma patients who were highly catabolic and hyper-metabolic. One group of subjects received 20 grams of OKG per day and showed a significant increase in protein turnover as well as a an increase in blood levels of insulin, growth hormone, and free amino acids (glutamine, proline and ornithine) compared to subjects not receiving OKG supplements.
Safety No apparent side effects have been noted with OKG supplementation at the doses studied (10-15 grams/day), although there have been anecdotal reports of increased appetite – perhaps owing to elevated insulin levels (??).
Value OKG supplements, taken at a dose shown to produce effects (10-15 grams per day) is a fairly expensive regimen. At $30-$35 per 100 capsule bottle (1250 mg capsules), a one month supply will cost over $100. For stimulating increases in muscle mass, creatine may be able to provide the same end benefit – at a much lower cost per day.
Dosage OKG has been used at doses of 10-15 grams per day in healthy men and short-stature children.
References 1. Cochard A, Guilhermet R, Bonneau M. Plasma growth hormone (GH), insulin and amino acid responses to arginine with or without aspartic acid in pigs. Effect of the dose. Reprod Nutr Dev 1998 May-Jun;38(3):331-43.
2. Jeevanandam M, Petersen SR. Substrate fuel kinetics in enterally fed trauma patients supplemented with ornithine alpha ketoglutarate. Clin Nutr 1999 Aug;18(4):209-17
~~~~~~~~~~~~~~~~~~~
ROBERT D. CHETLIN, RACHEL A. YEATER, IRMA H. ULLRICH, W. GUYTON HORNSBY, JR., ¹CARL J. MALANGA, AND RANDALL W. BRYNER. The Effect Of Ornithine Alpha-Ketoglutarate (Okg) On Healthy, Weight Trained Men. JEPonline, 3(4):37-47, 2000. The purposes of this study were to determine if OKG consumption (10 grams/day) improves strength, power and body composition in weight-trained men, and; evaluate OKG-effects on insulin and growth hormone blood concentrations, dietary intake, training intensity and volume. Eighteen resistance-trained men (age range 18-35) participated in a six-week double-blind study. Subjects were randomly assigned to an experimental (n=8) or placebo (n=10) group and were subsequently tested in 1-RM squat, 1-RM bench press, Wingate test, vertical jump, and hydrostatic weighing. After a 12-hour fast, subjects received 75g carbohydrate drinks and either OKG (10 grams) or placebo. Blood samples were obtained at baseline, 30, 60, and 90 minutes and analyzed for growth hormone, insulin and glucose. Subjects recorded their diet and training. Training volumes were similar between groups at study start and conclusion. Baseline dietary data was similar between groups except OKG-group consumed more carbohydrates (329±77g vs. 250±68g, p<0.05). Macronutrient consumption, however, was not different between groups during the experiment. Performance variables were not different between groups during the course of the study. The OKG group had a greater percentage increase in bench press strength (114±9kg vs. 123±2kg, 6.6% increase) versus controls (117±2kg vs. 118±2kg, 1.5 % increase), p<0.05. Strength gains in the squat were not different between groups. Acute training variables (i.e. sets, repetitions, exercise number) declined in both groups, while training intensity increased. Total training volume was not different between groups. No differences were noted between groups in mean levels of insulin or growth hormone after six weeks following OKG challenge. Conclusion: OKG did not alter insulin or growth hormone blood concentrations after six weeks in experienced weight-trained men. OKG does not result in increased training intensity, training volume, or muscle mass in free-living men. OKG effects on strength are unclear since bench press performance improved but squat performance did not.
~~~~~~~~~~~~~~~~~~~~~~
That being said, if you're looking into a product like NO2, you're better off saving your money and making it yourself
BornAgainPagan
New member
thank you. that was quite informative.
obiwan9962
New member
hmmmmm
BornAgainPagan
New member
yeah it's the one you pay 5 times as much for. been taking it for 3 days now and it does seem to give me a little better pump but kinda makes you feel flushed all the time. it also seems to have a mild like viagra effect.
Similar threads
