Strong evidence shows antioxidant supplements such as vitamins are not effective against gastro-intestinal cancer, researchers say.
That is the conclusion of a major review and analysis of previously published randomized trials. The review was carried in this week's issue of Britain's The Lancet.
The report said some combinations of supplements may even slightly increase gastro-intestinal cancer risk, while selenium may be associated with a risk reduction.
The human diet is a complex mix of oxidants and antioxidants. Excess oxidants can cause cancer by inducing gene mutations, it said.
The review was done by Goran Bjelakovic of the University of Niss in Serbia-Montenegro and his colleagues.
They group reviewed all randomized trials comparing antioxidant supplements with placebo for prevention of gastrointestinal cancers.
"We could not find evidence that antioxidant supplements can prevent gastrointestinal cancers; on the contrary, they seem to increase overall mortality

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