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From the article:
http://www.wzw.tu-muenchen.de/fml/physio/forsch/99fa-01.htm
"The discovery of FORMANN et al. (1998) (see also PICARD, 1998) that orphan nuclear receptors or CAR (constitutive active receptors) are located in the nucleus raises even more directly the question of previously unknown ways in which sex hormone metabolites act. Their significance has not yet been fully explained. However, it is already clear - as the findings on binding and deactivation by the androgenic metabolites androstenol and androstanol show - that there is a potential for steroid effects in the nucleus that can give rise to entirely new qualities, which could affect the biological effect of metabolites in particular. The most recent tests also show that steroid hormones and their metabolites can be responsible for a large number of direct effects via hitherto unidentified membrane receptors (NORMAN and WEHLING, 1998); more research is needed here too."
" Although it is still speculation, we cannot rule out the possibility of xenobiotic compounds such as trenbolone or its metabolites developing molecular-based effects which have not yet been reckoned with but which, in the context of the residue values tolerated so far, could mean that the potential effects, on consumers too, are of a different nature. Further investigations led to the discovery of the irreversible covalent binding of trenbolone to the cellular macromolecules. Although less than 0.5 % of the total initial dose remains in the body in this way (HOFFMANN, 1995), it can accumulate over time."
"The covalent binding of trenbolone residues to DNA and proteins has to be reconsidered."
http://www.wzw.tu-muenchen.de/fml/physio/forsch/99fa-01.htm
"The discovery of FORMANN et al. (1998) (see also PICARD, 1998) that orphan nuclear receptors or CAR (constitutive active receptors) are located in the nucleus raises even more directly the question of previously unknown ways in which sex hormone metabolites act. Their significance has not yet been fully explained. However, it is already clear - as the findings on binding and deactivation by the androgenic metabolites androstenol and androstanol show - that there is a potential for steroid effects in the nucleus that can give rise to entirely new qualities, which could affect the biological effect of metabolites in particular. The most recent tests also show that steroid hormones and their metabolites can be responsible for a large number of direct effects via hitherto unidentified membrane receptors (NORMAN and WEHLING, 1998); more research is needed here too."
" Although it is still speculation, we cannot rule out the possibility of xenobiotic compounds such as trenbolone or its metabolites developing molecular-based effects which have not yet been reckoned with but which, in the context of the residue values tolerated so far, could mean that the potential effects, on consumers too, are of a different nature. Further investigations led to the discovery of the irreversible covalent binding of trenbolone to the cellular macromolecules. Although less than 0.5 % of the total initial dose remains in the body in this way (HOFFMANN, 1995), it can accumulate over time."
"The covalent binding of trenbolone residues to DNA and proteins has to be reconsidered."
