depends on you weight......you can stay on longer then 2 weeks if you take zaditan or certain over the counter drugs......when i was at 180lbs and 12%bf, i went up to 200mcg/day......but i worked up and when i got to 200mcg i stayed their for a couple days and worked back down.....I here some people go up to something like 600mcg a day, but wouldnt advise it.