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The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program.
Author: Broeder, C E : Quindry, J : Brittingham, K : Panton, L : Thomson, J : Appakondu, S : Breuel, K : Byrd, R : Douglas, J : Earnest, C : Mitchell, C : Olson, M : Roy, T : Yarlagadda, C
Citation: Arch-Intern-Med. 2000 Nov 13; 160(20): 3093-104
Abstract: Androstenedione is a prohormone involved in the synthesis of testosterone. It is marketed with androstenediol to improve sexual performance, reduce body fat levels, and increase muscle mass. To study the hormonal and physiological effects of androstenedione and androstenediol 50 men, aged 35-65 years, were enrolled in a double-blind study while participating in a 12-week, high-intensity resistance training program. Twice a day these men received 100 mg of androstenedione, 100 mg of androstenediol, or a placebo. Serum sex hormone and blood lipid profiles as well as body composition and muscular strength assessment were determined. Androstenedione and androstenediol supplementation increased estrogen-related compounds, altered male hormone profiles, and adversely affected high-density lipoprotein (HDL) cholesterol levels, however, total and free testosterone and serum hormone-binding protein were unchanged. Within one month of androstenedione use, the synthesis of testosterone was decreased. Compared with the placebo, neither supplement enhanced the adaptation to resistance training for body composition or muscular strength. Overall any benefits derived from consuming the testosterone precusor supplements are outweighed by their negative side effects on blood lipid and hormone profiles.
Author: Broeder, C E : Quindry, J : Brittingham, K : Panton, L : Thomson, J : Appakondu, S : Breuel, K : Byrd, R : Douglas, J : Earnest, C : Mitchell, C : Olson, M : Roy, T : Yarlagadda, C
Citation: Arch-Intern-Med. 2000 Nov 13; 160(20): 3093-104
Abstract: Androstenedione is a prohormone involved in the synthesis of testosterone. It is marketed with androstenediol to improve sexual performance, reduce body fat levels, and increase muscle mass. To study the hormonal and physiological effects of androstenedione and androstenediol 50 men, aged 35-65 years, were enrolled in a double-blind study while participating in a 12-week, high-intensity resistance training program. Twice a day these men received 100 mg of androstenedione, 100 mg of androstenediol, or a placebo. Serum sex hormone and blood lipid profiles as well as body composition and muscular strength assessment were determined. Androstenedione and androstenediol supplementation increased estrogen-related compounds, altered male hormone profiles, and adversely affected high-density lipoprotein (HDL) cholesterol levels, however, total and free testosterone and serum hormone-binding protein were unchanged. Within one month of androstenedione use, the synthesis of testosterone was decreased. Compared with the placebo, neither supplement enhanced the adaptation to resistance training for body composition or muscular strength. Overall any benefits derived from consuming the testosterone precusor supplements are outweighed by their negative side effects on blood lipid and hormone profiles.
