Anavar science - How does it work?

[paul allen]

I'm wanting to do a cutting cycle in early march consisting of test/var.

I would really like to know the science behind anavar.

-How is it that it is only mildly suppressive?

-How harsh on the liver and why less that other orals?

-How can it make you stronger without adding bodyweight, or very little?

-Why are there very few sides, no acne, hair loss, bp?


Input much appreciated (karma), just really want to know the gritty science behind it, don't understand how it can be so good without sides, sounds too good to be true, everything else has a down side, sides wise!

 

[JibbyJabba]

The science behind anavar is no different than the science behind any anabolic steroid. It's function in the body is a direct result of it's molecular structure. There are lots of good websites that give the run down of basic chemistry/ biochemistry/ pharmacology, but that's what you would have to have at least an elementary understanding of to truly know the "science" behind anavar... or any AS for that matter.

 

[JibbyJabba]

Though, I guess it's possible you already have this sort of knowledge and you are specifically asking about it's chemical structure... in which case my first response is worthless...

I have to go... I am meeting Cliff Huxtable at the Four Seasons...

 

[paul allen]

I have to go... I am meeting Cliff Huxtable at the Four Seasons...

Four Seasons? Isn't that a little far down town?

Yeah I appreciate your response but my first degree was biochem and I have just completed 1st phd in chemistry. I am wanting to know specific science. I do know how AAS work on the whole, I just wanted specifics on var to answer those questions.

 

[JibbyJabba]

Four Seasons? Isn't that a little far down town?

Yeah I appreciate your response but my first degree was biochem and I have just completed 1st phd in chemistry. I am wanting to know specific science. I do know how AAS work on the whole, I just wanted specifics on var to answer those questions.

HAHA... that occured to me after I posted it... sorry...

I'm not really hungry, I just need to have reservations somewhere.

JJ

 

[paul allen]

I'm not really hungry, I just need to have reservations somewhere.

JJ

Haha, at the risk of sounding very geeky, the correct response was 'no, they have one down here now, yeah, it's very good', but I'll except yours van patten.

Right, back to topic. Anyone got any science for me?

 

[Triple-G]

I would really like to know the science behind anavar.

-How is it that it is only mildly suppressive?

it is suppressive, studies have shown that (at least in boys). but every non-aromatizing roid is less suppressive (except deca and probably fina) than aromatizing AS, since estrogen also exerts a negative feedback on the Hypothalamus.

-How harsh on the liver and why less that other orals?

its 17aa and therefore not less hepatoxic then other oral AS (except Primo which is not 17aa). But ox is taken at lower doses, compare eg 100mg Anadrol to 30mg Anavar, therefore less people on ox wind up with jaundice then those on dbol or anadrol.

-How can it make you stronger without adding bodyweight, or very little?

strength comes not only from muscle mass but also from nerve functions, how many fibers one can recruit at once and so on. and every non-aromatizing AS leads to less water retention and therefore less mass.

-Why are there very few sides, no acne, hair loss, bp?

the testosterone molecule has been altered to dampen androgenic properties; and people use lower doses ...

you will see sides at 100mg per day though. i think that every good attribute ox is said to comes mostly from the lower doses. if all would use anadrol at 30mg per day, it would also yield low sides.

 

[paul allen]

Re: Re: Anavar science - How does it work?

it is suppressive, studies have shown that (at least in boys). but every non-aromatizing roid is less suppressive (except deca and probably fina) than aromatizing AS, since estrogen also exerts a negative feedback on the Hypothalamus.


its 17aa and therefore not less hepatoxic then other oral AS (except Primo which is not 17aa). But ox is taken at lower doses, compare eg 100mg Anadrol to 30mg Anavar, therefore less people on ox wind up with jaundice then those on dbol or anadrol.


strength comes not only from muscle mass but also from nerve functions, how many fibers one can recruit at once and so on. and every non-aromatizing AS leads to less water retention and therefore less mass.


the testosterone molecule has been altered to dampen androgenic properties; and people use lower doses ...

you will see sides at 100mg per day though. i think that every good attribute ox is said to comes mostly from the lower doses. if all would use anadrol at 30mg per day, it would also yield low sides.

Thats some good reponses, thanks. However think some are inaccurate/wrong.
I was under the impression that var wasn't 17aa, but was actually alkylated on carbon-1, I think I read this somewhere, someone mentioned this being less liver toxic. Can't really remember though, thats why I'm asking.

How do non-aromatising AAS stimulate more nerves? I don't really get your point here.

I agree with smaller doses maybe being responsible for less sides, but people still seem very happy with gains from 50mg ED, which is what I'm going to do.

 

[tournesol]

hey guys !

I'm doing anavar right now, 25 mg to start with. Do you split the dose up through the day or take it all hours before training ?

 

[BigMike]

I would suggest splitting it into three doses a day at 8 hour intervals to keep a steady dose.

 

[rugbybear]

i would also like to know the mechanism by which var increases strength,

Author L Rea tells us that it is (partly) to do with the elevation in Creatine phoshate levels, if there is a way by which var increases motor nerve activation this would be the same effect as many years of training! Would this then stay after cessation of use? Probably not.

Hey Pual where do you train in Manc?

 

[paul allen]

Good point rugbybear, I am curoius if theres any truth to this nerve thing. Whats the story.

I tend to be at different locations alot in North west, but its good as I member of total fitness, member of one, member of all, so I can go to one at wilmslow or new ones opened in bury and preston. Not willing to divuldge my main gym though, sorry!

 

[milo hobgoblin]

....

Im not sure how to put it plainly... but it has to do with receptor competition.

Ive actually seen this explained but I cant remember exactly how the author put it (I only minored in Biochem...major was molecular bio)

By some strange function Anavar actually increases receptor affinity for free testosterone by weakling binding to the recepetors and then being displaced. This somehow increases receptor density... at the same time populating existing receptors more fully.

Im sorry for the vague explanation... but if you look into it a little Im sure you can find the study where they talk about this. I threw out most of my journals years ago.. (ex-wife made me clean up all that "college crap" Id never use again. LOL)

Oh and as far as the creatine explanation goes... that aint it... Deca has been shown to provide the best creatine loading mechanism of any AAS.

It could be a combination.... because it so mildly supprseive (Ox)... circulating free test levels will stay higher while on it... so you get the added effect of natural test and Anavar.

The biggest problem with Ox.. is the COST!

 

[paul allen]

Re: ....

Im not sure how to put it plainly... but it has to do with receptor competition.

Ive actually seen this explained but I cant remember exactly how the author put it (I only minored in Biochem...major was molecular bio)

By some strange function Anavar actually increases receptor affinity for free testosterone by weakling binding to the recepetors and then being displaced. This somehow increases receptor density... at the same time populating existing receptors more fully.

Im sorry for the vague explanation... but if you look into it a little Im sure you can find the study where they talk about this. I threw out most of my journals years ago.. (ex-wife made me clean up all that "college crap" Id never use again. LOL)

Oh and as far as the creatine explanation goes... that aint it... Deca has been shown to provide the best creatine loading mechanism of any AAS.

It could be a combination.... because it so mildly supprseive (Ox)... circulating free test levels will stay higher while on it... so you get the added effect of natural test and Anavar.

The biggest problem with Ox.. is the COST!

Thats very interesting, I hope its true. It would explain the synergistic effect people see when stacking it with test, as I am going to do .

I'll look for that study, least I have something to go at.
Keep em coming guys,
Have some karma milo

 

[paul allen]

This is a good suggestion, it could mean safer cycles, with good gains.

Imagine this stack:
Var - 50mg ED
Test - 300mg EW
Proviron - 75mg ED
Avena sativa - 2g ED

By lowering SHBG, massive gains could be achieved with low dose test and var.
I'll get looking for that study.

 

[milo hobgoblin]

..

but why the proviron?

You would be much better off making up the difference with Test.


One thing to note... straight test in any ester form just isnt that suppresive.

Its all the wierd crap (like fina and deca) that people take along with it that causes the majority of the suppression.

Even 500mg a week of test wouldnt suppress you all that much.

 

[wootoom]

take off your clothes well dont just stare at it EAT IT!!!!

 

[paul allen]

Re: ..

but why the proviron?

You would be much better off making up the difference with Test.


One thing to note... straight test in any ester form just isnt that suppresive.

Its all the wierd crap (like fina and deca) that people take along with it that causes the majority of the suppression.

Even 500mg a week of test wouldnt suppress you all that much.

Proviron binds SHBG doesn't it, thereby freeing up more test, making that 300mg, maybe seem like 800mg, if in normal SHBG activity.

I'm with you that derivatives can cause alot of suppression (deca, oh god, have I been there), but I still think that any exogenous AAS is gonna suppress, whether its test or not.

Anyway, I looked for a study linked to what you said on pubmed and sciencedirect and couldn't find anything.

Anyone else??

woo, glad to see more AP followers, do you like phil collins?......Sussudio, a personal favourite!

 

[jh1]

Re: Re: Re: Anavar science - How does it work?

Thats some good reponses, thanks. However think some are inaccurate/wrong.
I was under the impression that var wasn't 17aa, but was actually alkylated on carbon-1, I think I read this somewhere, someone mentioned this being less liver toxic. Can't really remember though, thats why I'm asking.

How do non-aromatising AAS stimulate more nerves? I don't really get your point here.

I agree with smaller doses maybe being responsible for less sides, but people still seem very happy with gains from 50mg ED, which is what I'm going to do.

1. Var is 17aa. Like 3-g said, it is considered less toxic because it is affective in smaller doses. Period.

2. 3-g didn't say non-aromatising AAS stimulate more nevers, he said they lead to less water retention - which is true. His answer about stimulating nevers was in response to your question about how does it add strengh without adding mass - answer: by stimulating more nerves (although this is new to me)

3. You will be happy with 50mg ed, I wouldn't go above that dose.

 

[JibbyJabba]

take off your clothes well dont just stare at it EAT IT!!!!

That's a very fine Chardonnay you're not drinking.

 

[hayabusaguy06]

How do you split a 25mg cap.up?

 

[aquatic_glories]

i would also like to know the mechanism by which var increases strength,

Author L Rea tells us that it is (partly) to do with the elevation in Creatine phoshate levels, if there is a way by which var increases motor nerve activation this would be the same effect as many years of training! Would this then stay after cessation of use? Probably not.

QUOTE]

This is my main research for AAS right now. It would be great to get opinions from vet's.